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Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1553-1556

2005

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Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4350-4353

2009

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Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1930-1933

2007

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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4354-4358

2009

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A novel synthesis of substituted 4H-pyrazolo[3,4-d]pyrimidin-4-ones

Tetrahedron letters, 2007-06, Vol.48 (23), p.3983-3986

2007

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Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator

Journal of the American Chemical Society, 2008-06, Vol.130 (24), p.7584-7591

2008

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Urotensin-II receptor antagonists: Synthesis and SAR of N-cyclic azaalkyl benzamides

Bioorganic & medicinal chemistry letters, 2008-07, Vol.18 (14), p.3950-3954

2008

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Chloromethylaluminum 2 (2-propenyl)anilide - a convenient reagent for the conversion of lactones into protected hydroxy acids

Tetrahedron letters, 1987, Vol.28 (29), p.3327-3330

1987

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Ring-expansion of a dihalogenocarbene adduct of a cycloheptene derivative and the corresponding retro-reaction

Tetrahedron letters, 1987, Vol.28 (16), p.1827-1829

1987

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Synthesis of [6](2,4)pyridinophanes

Journal of the Chemical Society, Perkin Transactions 1, 1987, p.2829

1987

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Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1445-1450

2001

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Action of tert-butyl azidoformate on the conjugate bases of 1,2,3,4-tetrahydro-9H-carbazole and other indole derivatives

Tetrahedron letters, 1985, Vol.26 (16), p.2017-2020

1985

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Studies in the protection of pyrrole and indole derivatives

Journal of the Chemical Society, Perkin Transactions 1, 1986, p.2181

1986

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Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (24), p.3677-3682

1998

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Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1441-1444

2001

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Physico-chemical properties of a novel surfactant derived from 6-aminopenicillanic acid and its use in capillary electrophoresis for chiral discrimination

Chemical communications (Cambridge, England), 1996 (5), p.671

1996

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A sensitive and selective method for the analysis of complex mixtures of sugars and linear oligosaccharides

Journal of the Chemical Society. Chemical communications, 1994 (14), p.1691-1692

1994

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Palladium Catalysed Coupling of Iodoquinolines and Acetylenes -- A Novel Entry to the Pyrrolo[3,2,1-ij]quinoline Nucleus

Heterocycles, 1997, Vol.45 (12), p.2395

1997

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Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease

Bioorganic & medicinal chemistry letters, 2000-10, Vol.10 (20), p.2279-2282

2000

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BASE INDUCED REACTION OF AN AZETIDIN-2-ONE: FORMATION OF A NOVEL [1,4]-DIAZEPINEDIONE

Synthetic communications, 2001-01, Vol.31 (17), p.2713-2718

2001

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alpha.-Oximino amide trianions in the stereoselective synthesis of isoxazolines and .gamma.-hydroxy .alpha.-amino acids

Journal of organic chemistry, 1991-03, Vol.56 (5), p.1894-1901

1991

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The reaction between bromine and (E)-1-trimethylsilylcyclo-octene

Journal of the Chemical Society. Chemical communications, 1984 (15), p.988-989

1984

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Stealth stereocontrol: stereochemical reversal of a Michael addition reaction

Journal of the American Chemical Society, 1991-12, Vol.113 (26), p.9820-9824

1991

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A synthesis of pyrrole derivatives from O-(2-hydroxyethyl)-ketoximes

Journal of the Chemical Society. Chemical communications, 1986 (12), p.903

1986

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Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture

Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase

Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors

A novel synthesis of substituted 4H-pyrazolo[3,4-d]pyrimidin-4-ones

Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator

Urotensin-II receptor antagonists: Synthesis and SAR of N-cyclic azaalkyl benzamides

Chloromethylaluminum 2 (2-propenyl)anilide - a convenient reagent for the conversion of lactones into protected hydroxy acids

Ring-expansion of a dihalogenocarbene adduct of a cycloheptene derivative and the corresponding retro-reaction

Synthesis of [6](2,4)pyridinophanes

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

Action of tert-butyl azidoformate on the conjugate bases of 1,2,3,4-tetrahydro-9H-carbazole and other indole derivatives

Studies in the protection of pyrrole and indole derivatives

Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease

Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

Physico-chemical properties of a novel surfactant derived from 6-aminopenicillanic acid and its use in capillary electrophoresis for chiral discrimination

A sensitive and selective method for the analysis of complex mixtures of sugars and linear oligosaccharides

Palladium Catalysed Coupling of Iodoquinolines and Acetylenes -- A Novel Entry to the Pyrrolo[3,2,1-ij]quinoline Nucleus

Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease

BASE INDUCED REACTION OF AN AZETIDIN-2-ONE: FORMATION OF A NOVEL [1,4]-DIAZEPINEDIONE

alpha.-Oximino amide trianions in the stereoselective synthesis of isoxazolines and .gamma.-hydroxy .alpha.-amino acids

The reaction between bromine and (E)-1-trimethylsilylcyclo-octene

Stealth stereocontrol: stereochemical reversal of a Michael addition reaction

A synthesis of pyrrole derivatives from O-(2-hydroxyethyl)-ketoximes

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