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Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Pharmaceutical research, 2024-03, Vol.41 (3), p.441-462

2024

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Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Pharmaceutical research, 2023-11, Vol.40 (11), p.2513-2523

2023

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E‑Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells

ACS omega, 2021-03, Vol.6 (10), p.6708-6713

2021

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Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.412-421

2021

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Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR−) Rats

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.404-411

2021

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Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo

Small (Weinheim an der Bergstrasse, Germany), 2020-02, Vol.16 (7), p.e1906360-n/a

2020

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Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease

Journal of pharmaceutical sciences, 2019-07, Vol.108 (7), p.2484-2489

2019

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Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

Analytical and bioanalytical chemistry, 2018-08, Vol.410 (21), p.5287-5300

2018

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Effect of Liver Disease on Hepatic Transporter Expression and Function

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2282-2294

2017

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Prediction of Hepatic Efflux Transporter-Mediated Drug Interactions: When Is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2401-2406

2017

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Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids

Analytical chemistry (Washington), 2016-07, Vol.88 (14), p.7041-7048

2016

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Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.443-459

2016

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An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

Journal of pharmaceutical sciences, 2013-09, Vol.102 (9), p.3037-3057

2013

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Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Journal of pharmaceutical sciences, 2011-09, Vol.100 (9), p.3636-3654

2011

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Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

Pharmaceutical research, 2010-09, Vol.27 (9), p.1987

2010

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Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

Pharmaceutical research, 2009-08, Vol.26 (8), p.1942-1951

2009

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Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Pharmaceutical research, 2008-08, Vol.25 (8), p.1851-1860

2008

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P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide

Pharmaceutical research, 2004-07, Vol.21 (7), p.1294-1302

2004

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The complexities of hepatic drug transport: current knowledge and emerging concepts

Pharmaceutical research, 2004-05, Vol.21 (5), p.719-735

2004

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Use of the InteliSite® capsule to study ranitidine absorption from various sites within the human intestinal tract

Pharmaceutical research, 1998-12, Vol.15 (12), p.1869-1875

1998

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Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration

Pharmaceutical research, 1998-10, Vol.15 (10), p.1533-1539

1998

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Effect of pancreatico-biliary secretions and GI transit time on the absorption and pharmacokinetic profile of ranitidine in humans

Pharmaceutical research, 1998-08, Vol.15 (8), p.1281-1285

1998

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Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat

Pharmaceutical research, 1998-04, Vol.15 (4), p.599-605

1998

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Hepatic distribution and clearance of antisense oligonucleotides in the isolated perfused rat liver

Pharmaceutical research, 1997-04, Vol.14 (4), p.516-521

1997

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Solid-phase extraction and determination of ranitidine in human plasma by a high-performance liquid chromatographic method utilizing midbore chromatography

Journal of chromatography. B, Biomedical sciences and applications, 1997-01, Vol.688 (2), p.350-353

1997

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Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

E‑Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells

Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression

Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR−) Rats

Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo

Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease

Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

Effect of Liver Disease on Hepatic Transporter Expression and Function

Prediction of Hepatic Efflux Transporter-Mediated Drug Interactions: When Is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide

The complexities of hepatic drug transport: current knowledge and emerging concepts

Use of the InteliSite® capsule to study ranitidine absorption from various sites within the human intestinal tract

Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration

Effect of pancreatico-biliary secretions and GI transit time on the absorption and pharmacokinetic profile of ranitidine in humans

Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat

Hepatic distribution and clearance of antisense oligonucleotides in the isolated perfused rat liver

Solid-phase extraction and determination of ranitidine in human plasma by a high-performance liquid chromatographic method utilizing midbore chromatography

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