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The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites

Drug metabolism and disposition, 2008-09, Vol.36 (9), p.1780

2008

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Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat

Drug metabolism and disposition, 2005-09, Vol.33 (9), p.1367

2005

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Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

Bioorganic & medicinal chemistry, 2011-12, Vol.19 (23), p.7023-7032

2011

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Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood

Drug metabolism and disposition, 2005-06, Vol.33 (6), p.719

2005

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The Dual-Targeted HER1/HER2 Tyrosine Kinase Inhibitor Lapatinib Strongly Potentiates the Cardiac Myocyte-Damaging Effects of Doxorubicin

Cardiovascular toxicology, 2013-03, Vol.13 (1), p.33-47

2013

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Dihydroorotase catalyzes the ring opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187)

Drug metabolism and disposition, 2002-12, Vol.30 (12), p.1431

2002

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High-throughput fluorescence flow-injection topoisomerase II inhibition assay

Journal of chromatography. B, Biomedical sciences and applications, 2001-09, Vol.760 (2), p.263-269

2001

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Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (11), p.3974-3984

2010

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Chemical reactivity and microbicidal action of bethoxazin

Bioorganic & medicinal chemistry, 2012-02, Vol.20 (4), p.1494-1501

2012

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Role of NADPH cytochrome P450 reductase in activation of RH1

Cancer chemotherapy and pharmacology, 2007-10, Vol.60 (5), p.713-723

2007

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The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (13), p.4575-4582

2009

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Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry

Journal of mass spectrometry., 2007-05, Vol.42 (5), p.681-688

2007

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The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds

Bioorganic & medicinal chemistry, 2008-04, Vol.16 (7), p.3959-3968

2008

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The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925

Cancer chemotherapy and pharmacology, 2002-12, Vol.50 (6), p.509-513

2002

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Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II

Cancer chemotherapy and pharmacology, 2006-02, Vol.57 (2), p.221-233

2006

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Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide

Cancer chemotherapy and pharmacology, 2003-08, Vol.52 (2), p.167-174

2003

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Pharmacodynamics of the Hydrolysis-Activation of the Cardioprotective Agent (+)-1,2-Bis(3,5-dioxopiperazinyl-1-yl)propane

Journal of pharmaceutical sciences, 1994-01, Vol.83 (1), p.64-67

Hasinoff, Brian B.

1994

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Antioxidants and dipyridamole inhibit HIV-1 gp120-induced free radical-based oxidative damage to human monocytoid cells

Journal of acquired immune deficiency syndromes and human retrovirology, 1997-12, Vol.16 (4), p.223

1997

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An HPLC and spectrophotometric study of the hydrolysis of ICRF-187 (dexrazoxane, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) and its one-ring opened intermediates

International journal of pharmaceutics, 1994-06, Vol.107 (1), p.67-76

Hasinoff, Brian B.

1994

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Relative plasma levels of the cardioprotective drug dexrazoxane and its two active ring-opened metabolites in the rat

Drug metabolism and disposition, 1999-02, Vol.27 (2), p.265

1999

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Pharmacokinetics of etoposide in cancer patients treated with high-dose etoposide and with dexrazoxane (ICRF-187) as a rescue agent

Cancer chemotherapy and pharmacology, 2004, Vol.53 (1), p.91-93

2004

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The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin-and mitoxantrone-induced cardiotoxicity

Cancer chemotherapy and pharmacology, 2001-10, Vol.48 (4), p.297-304

2001

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Comparison of the chronic toxicity of piroxantrone, losoxantrone and doxorubicin in spontaneously hypertensive rats

Toxicology (Amsterdam), 1998-06, Vol.128 (1), p.35-52

1998

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Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II

Biochemical pharmacology, 1997-06, Vol.53 (12), p.1843-1853

1997

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Collateral sensitivity to the bisdioxopiperazine dexrazoxane (ICRF-187) in etoposide (VP-16)-resistant human leukemia K562 cells

Biochemical pharmacology, 1996-08, Vol.52 (4), p.635-642

1996

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The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites

Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat

Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood

The Dual-Targeted HER1/HER2 Tyrosine Kinase Inhibitor Lapatinib Strongly Potentiates the Cardiac Myocyte-Damaging Effects of Doxorubicin

Dihydroorotase catalyzes the ring opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187)

High-throughput fluorescence flow-injection topoisomerase II inhibition assay

Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Chemical reactivity and microbicidal action of bethoxazin

Role of NADPH cytochrome P450 reductase in activation of RH1

The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds

Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry

The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds

The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925

Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II

Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide

Pharmacodynamics of the Hydrolysis-Activation of the Cardioprotective Agent (+)-1,2-Bis(3,5-dioxopiperazinyl-1-yl)propane

Antioxidants and dipyridamole inhibit HIV-1 gp120-induced free radical-based oxidative damage to human monocytoid cells

An HPLC and spectrophotometric study of the hydrolysis of ICRF-187 (dexrazoxane, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) and its one-ring opened intermediates

Relative plasma levels of the cardioprotective drug dexrazoxane and its two active ring-opened metabolites in the rat

Pharmacokinetics of etoposide in cancer patients treated with high-dose etoposide and with dexrazoxane (ICRF-187) as a rescue agent

The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin-and mitoxantrone-induced cardiotoxicity

Comparison of the chronic toxicity of piroxantrone, losoxantrone and doxorubicin in spontaneously hypertensive rats

Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II

Collateral sensitivity to the bisdioxopiperazine dexrazoxane (ICRF-187) in etoposide (VP-16)-resistant human leukemia K562 cells

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