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NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells

Acta pharmacologica Sinica, 2021-04, Vol.42 (4), p.613-623

2021

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A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma

Drug resistance updates, 2023-05, Vol.68, p.100957-100957, Article 100957

2023

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Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice

European journal of pharmacology, 1999-02, Vol.366 (2), p.261-269

1999

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Involvement of μ-opioid receptors and α-adrenoceptors in the immunomodulatory effects of dihydroetorphine

European journal of pharmacology, 1998-07, Vol.353 (1), p.79-85

1998

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Inhibiting wear particles-induced osteolysis with doxycycline

Acta pharmacologica Sinica, 2007-10, Vol.28 (10), p.1603-1610

2007

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A novel STAT3 inhibitor negatively modulates platelet activation and aggregation

Acta pharmacologica Sinica, 2017-05, Vol.38 (5), p.651-659

2017

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Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

Acta pharmacologica Sinica, 2022-04, Vol.43 (4), p.788-796

2022

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Targeting EGFRL858R/T790M and EGFRL858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry

Medicinal research reviews, 2018-09, Vol.38 (5), p.1550-1581

2018

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A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

Acta pharmacologica Sinica, 2022-02, Vol.43 (2), p.483-493

2022

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Osteopontin attenuates early brain injury through regulating autophagy‐apoptosis interaction after subarachnoid hemorrhage in rats

CNS neuroscience & therapeutics, 2019-10, Vol.25 (10), p.1162-1172

2019

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Discovery and Optimization of 3‑(2-(Pyrazolo[1,5‑a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3281-3295

2013

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A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects

European journal of pharmaceutical sciences, 2023-12, Vol.191, p.106598-106598, Article 106598

2023

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Identification and Characterization of Three Chitinases with Potential in Direct Conversion of Crystalline Chitin into N , N '-diacetylchitobiose

Marine drugs, 2022-02, Vol.20 (3), p.165

2022

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WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis

Frontiers in pharmacology, 2022-09, Vol.13, p.976117

2022

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Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway

Inflammopharmacology, 2023-02, Vol.31 (1), p.423-438

2023

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Acute Oral Toxicity and Acute Intraperitoneal Studies of Thermally Treated Ceftiofur

Chemical and Pharmaceutical Bulletin, 2020/11/01, Vol.68(11), pp.1061-1068

2020

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Increased Ingestion of Hydroxy-Methionine by Both Sows and Piglets Improves the Ability of the Progeny to Counteract LPS-Induced Hepatic and Splenic Injury with Potential Regulation of TLR4 and NOD Signaling

Antioxidants, 2022-02, Vol.11 (2), p.321

2022

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The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation

International journal of nanomedicine, 2013-01, Vol.8 (1), p.2473-2485

2013

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Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC

European journal of medicinal chemistry, 2016-02, Vol.109, p.1-12

2016

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Minocycline protects developing brain against ethanol-induced damage

Neuropharmacology, 2018-02, Vol.129, p.84-99

2018

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Epicardial delivery of a conductive membrane synchronizes conduction to reduce atrial fibrillation

Journal of controlled release, 2022-11, Vol.351, p.847-859

2022

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A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters

Acta pharmacologica Sinica, 2019-07, Vol.40 (7), p.895-907

2019

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Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex

Acta pharmacologica Sinica, 2021-10, Vol.42 (10), p.1556-1566

2021

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Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide–deoxynojirimycin Conjugates

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.5863-5873

2021

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Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy

Frontiers in pharmacology, 2019-07, Vol.10, p.833-833

2019

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NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells

A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma

Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice

Involvement of μ-opioid receptors and α-adrenoceptors in the immunomodulatory effects of dihydroetorphine

Inhibiting wear particles-induced osteolysis with doxycycline

A novel STAT3 inhibitor negatively modulates platelet activation and aggregation

Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

Targeting EGFRL858R/T790M and EGFRL858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry

A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

Osteopontin attenuates early brain injury through regulating autophagy‐apoptosis interaction after subarachnoid hemorrhage in rats

Discovery and Optimization of 3‑(2-(Pyrazolo[1,5‑a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors

A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects

Identification and Characterization of Three Chitinases with Potential in Direct Conversion of Crystalline Chitin into N , N '-diacetylchitobiose

WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis

Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway

Acute Oral Toxicity and Acute Intraperitoneal Studies of Thermally Treated Ceftiofur

Increased Ingestion of Hydroxy-Methionine by Both Sows and Piglets Improves the Ability of the Progeny to Counteract LPS-Induced Hepatic and Splenic Injury with Potential Regulation of TLR4 and NOD Signaling

The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation

Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC

Minocycline protects developing brain against ethanol-induced damage

Epicardial delivery of a conductive membrane synchronizes conduction to reduce atrial fibrillation

A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters

Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex

Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide–deoxynojirimycin Conjugates

Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy

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