UB Paderborn / Katalog / Suche / in CDI

Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling

Journal of clinical pharmacology, 2016-03, Vol.56 (3), p.266-283

2016

Link zum Volltext

Verfügbarkeit prüfen

Absorption, Distribution, Metabolism, and Excretion of [ 14 C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism

Drug metabolism and disposition, 2022-05, Vol.50 (5), p.600-612

2022

Link zum Volltext

Verfügbarkeit prüfen

Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation

Drug metabolism and disposition, 2010-06, Vol.38 (6), p.981

2010

Link zum Volltext

Verfügbarkeit prüfen

Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?

Drug metabolism and disposition, 2020-08, Vol.48 (8), p.613-621

2020

Link zum Volltext

Verfügbarkeit prüfen

Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.47

2012

Link zum Volltext

Verfügbarkeit prüfen

Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate

Drug metabolism and disposition, 2011-09, Vol.39 (9), p.1546

2011

Link zum Volltext

Verfügbarkeit prüfen

CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles

Drug metabolism and disposition, 2008-03, Vol.36 (3), p.523

2008

Link zum Volltext

Verfügbarkeit prüfen

CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.1966

2006

Link zum Volltext

Verfügbarkeit prüfen

Application of cytochrome P450 drug interaction screening in drug discovery

Combinatorial chemistry & high throughput screening, 2010-02, Vol.13 (2), p.145

2010

Link zum Volltext

Verfügbarkeit prüfen

Risk of tuberculosis in a large sample of patients with coeliac disease – a nationwide cohort study

Alimentary pharmacology & therapeutics, 2011-03, Vol.33 (6), p.689-696

2011

Link zum Volltext

Verfügbarkeit prüfen

Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction

Drug metabolism and disposition, 2011-07, Vol.39 (7), p.1188

2011

Link zum Volltext

Verfügbarkeit prüfen

In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract

Drug metabolism and disposition, 2009-09, Vol.37 (9), p.1848

2009

Link zum Volltext

Verfügbarkeit prüfen

The in vitro drug interaction potential of dietary supplements containing multiple herbal components

Drug metabolism and disposition, 2007-02, Vol.35 (2), p.185

2007

Link zum Volltext

Verfügbarkeit prüfen

Enzyme source effects on CYP2C9 kinetics and inhibition

Drug metabolism and disposition, 2006-11, Vol.34 (11), p.1903

2006

Link zum Volltext

Verfügbarkeit prüfen

Differential Time-Dependent Inactivation of P450 3A4 and P450 3A5 by Raloxifene: A Key Role for C239 in Quenching Reactive Intermediates

Chemical research in toxicology, 2007-12, Vol.20 (12), p.1778-1786

2007

Link zum Volltext

Verfügbarkeit prüfen

Ligand-Based Design of a Potent and Selective Inhibitor of Cytochrome P450 2C19

Journal of medicinal chemistry, 2012-02, Vol.55 (3), p.1205-1214

2012

Link zum Volltext

Verfügbarkeit prüfen

Impact of Sotorasib on the Pharmacokinetics and Pharmacodynamics of Metformin, a MATE1/2K Substrate, in Healthy Subjects

Clinical pharmacokinetics, 2023-02, Vol.62 (2), p.267-275

2023

Link zum Volltext

Verfügbarkeit prüfen

Oral Delivery of 1,3‐Dicyclohexylurea Nanosuspension Enhances Exposure and Lowers Blood Pressure in Hypertensive Rats

Basic & clinical pharmacology & toxicology, 2008-05, Vol.102 (5), p.453-458

2008

Link zum Volltext

Verfügbarkeit prüfen

Pharmacokinetics, Disposition, and Biotransformation of [ 14 C]Omecamtiv Mecarbil in Healthy Male Subjects after a Single Intravenous or Oral Dose

Drug metabolism and disposition, 2021-08, Vol.49 (8), p.619-628

2021

Link zum Volltext

Verfügbarkeit prüfen

Three-dimensional quantitative structure-activity relationship analysis of cytochromes p450: effect of incorporating higher-affinity ligands and potential new applications

Drug metabolism and disposition, 2005-07, Vol.33 (7), p.873

2005

Link zum Volltext

Verfügbarkeit prüfen

Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors

Drug metabolism and disposition, 2012-12, Vol.40 (12), p.2239

2012

Link zum Volltext

Verfügbarkeit prüfen

Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1523

2006

Link zum Volltext

Verfügbarkeit prüfen

Absorption, metabolism and excretion of [14C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate

Cancer chemotherapy and pharmacology, 2022-10, Vol.90 (4), p.357-367

2022

Link zum Volltext

Verfügbarkeit prüfen

A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives

Drug metabolism and disposition, 2003-07, Vol.31 (7), p.967

2003

Link zum Volltext

Verfügbarkeit prüfen

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1399-1423

2016

Link zum Volltext

Verfügbarkeit prüfen

Menü

Weitere Dienste

Einstellungen

Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling

Absorption, Distribution, Metabolism, and Excretion of [ 14 C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism

Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation

Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?

Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition

Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate

CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles

CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles

Application of cytochrome P450 drug interaction screening in drug discovery

Risk of tuberculosis in a large sample of patients with coeliac disease – a nationwide cohort study

Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction

In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract

The in vitro drug interaction potential of dietary supplements containing multiple herbal components

Enzyme source effects on CYP2C9 kinetics and inhibition

Differential Time-Dependent Inactivation of P450 3A4 and P450 3A5 by Raloxifene: A Key Role for C239 in Quenching Reactive Intermediates

Ligand-Based Design of a Potent and Selective Inhibitor of Cytochrome P450 2C19

Impact of Sotorasib on the Pharmacokinetics and Pharmacodynamics of Metformin, a MATE1/2K Substrate, in Healthy Subjects

Oral Delivery of 1,3‐Dicyclohexylurea Nanosuspension Enhances Exposure and Lowers Blood Pressure in Hypertensive Rats

Pharmacokinetics, Disposition, and Biotransformation of [ 14 C]Omecamtiv Mecarbil in Healthy Male Subjects after a Single Intravenous or Oral Dose

Three-dimensional quantitative structure-activity relationship analysis of cytochromes p450: effect of incorporating higher-affinity ligands and potential new applications

Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors

Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine

Absorption, metabolism and excretion of [14C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate

A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives

Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective

Aktive Filter

Suchergebnisse filtern