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Once-weekly vancomycin for patients receiving high-flux hemodialysis

American journal of health-system pharmacy, 2008-07, Vol.65 (13), p.1248-1253

2008

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Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

The Journal of pharmacology and experimental therapeutics, 2005-06, Vol.313 (3), p.1254-1262

2005

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Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

Neuropharmacology, 2012-02, Vol.62 (2), p.978-987

2012

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Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1443-1447

2006

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The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8538-8551

2017

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Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

Neuropharmacology, 2010, Vol.58 (1), p.185-194

2010

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In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice

The Journal of pharmacology and experimental therapeutics, 2010-11, Vol.335 (2), p.409-417

2010

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Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2678-2702

2015

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Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)

ChemMedChem, 2012-01, Vol.7 (1), p.123-133

2012

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Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2400-2403

2009

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1-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 Positive Allosteric Modulators for the Treatment of Psychosis

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1724-1739

2011

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Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4201-4205

2010

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Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5721-5726

2012

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3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2524-2529

2009

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Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes

Chemico-biological interactions, 2002-04, Vol.140 (1), p.81-92

2002

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Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5147-5152

2010

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Pyridyl amides as potent inhibitors of T-type calcium channels

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1692-1696

2011

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3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5493-5496

2008

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Characterisation of androstenone metabolism in pig liver microsomes

Chemico-biological interactions, 2004-03, Vol.147 (2), p.141-149

2004

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Once-weekly vancomycin for patients receiving high-flux hemodialysis

Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation

Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)

Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an N,N‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats

In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice

Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design

Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

1-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 Positive Allosteric Modulators for the Treatment of Psychosis

Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat

Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes

3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization

Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes

Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists

Pyridyl amides as potent inhibitors of T-type calcium channels

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators

Characterisation of androstenone metabolism in pig liver microsomes

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