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FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication

Oncogene, 2020-03, Vol.39 (12), p.2539-2549

2020

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Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium‐specific FAK‐kinase dead mice

The Journal of pathology, 2017-07, Vol.242 (3), p.358-370

2017

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IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease

Apoptosis (London), 2024-08, Vol.29 (7-8), p.1109-1125

2024

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Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer

Journal of experimental & clinical cancer research, 2018-07, Vol.37 (1), p.175-175, Article 175

2018

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Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth

The Journal of pathology, 2022-02, Vol.256 (2), p.235-247

2022

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Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma

Cancer biology & therapy, 2018-04, Vol.19 (4), p.316-327

2018

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Reactive Oxygen Species Inhibit Adhesion of Mesenchymal Stem Cells Implanted into Ischemic Myocardium via Interference of Focal Adhesion Complex

Stem cells (Dayton, Ohio), 2010-03, Vol.28 (3), p.555-563

2010

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Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

Oncogene, 2009-12, Vol.28 (49), p.4326-4343

2009

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DGKA interacts with SRC/FAK to promote the metastasis of non-small cell lung cancer

Cancer letters, 2022-04, Vol.532, p.215585-215585, Article 215585

2022

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Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

Journal of clinical oncology, 2012-05, Vol.30 (13), p.1527-1533

2012

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EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

Oncogene, 2012-12, Vol.31 (50), p.5132-5143

2012

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FAK in cancer: mechanistic findings and clinical applications

Nature reviews. Cancer, 2014-09, Vol.14 (9), p.598-610

2014

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Targeting FAK in anticancer combination therapies

Nature reviews. Cancer, 2021-05, Vol.21 (5), p.313-324

2021

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ECT2 promotes lung adenocarcinoma progression through extracellular matrix dynamics and focal adhesion signaling

Cancer science, 2021-02, Vol.112 (2), p.703-714

2021

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A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors

Annals of oncology, 2016-12, Vol.27 (12), p.2268-2274

2016

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FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

Oncotarget, 2015-03, Vol.6 (7), p.4757-4772

2015

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A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours

British journal of cancer, 2019-05, Vol.120 (10), p.975-981

2019

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Synergistic effects of combined BET and FAK inhibition against Vestibular Schwannomas in NF2-related Schwannomatosis

Oncogene, 2024-09, Vol.43 (40), p.2995-3002

2024

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ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Cancer research (Chicago, Ill.), 2021-02, Vol.81 (4), p.986-1000

2021

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FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

The Journal of cell biology, 2009-04, Vol.185 (2), p.357-370

2009

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Focal adhesion kinase confers lenvatinib resistance in hepatocellular carcinoma via the regulation of lysine‐deficient kinase 1

Molecular carcinogenesis, 2024-01, Vol.63 (1), p.173-189

2024

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FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors

Breast cancer research : BCR, 2020-06, Vol.22 (1), p.59-15, Article 59

2020

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p14ARF interacts with the focal adhesion kinase and protects cells from anoikis

Oncogene, 2017-08, Vol.36 (34), p.4913-4928

2017

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The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

Journal of experimental & clinical cancer research, 2019-06, Vol.38 (1), p.250-250, Article 250

2019

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FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium‐specific FAK‐kinase dead mice

IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease

Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer

Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma

Reactive Oxygen Species Inhibit Adhesion of Mesenchymal Stem Cells Implanted into Ischemic Myocardium via Interference of Focal Adhesion Complex

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

DGKA interacts with SRC/FAK to promote the metastasis of non-small cell lung cancer

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

FAK in cancer: mechanistic findings and clinical applications

Targeting FAK in anticancer combination therapies

ECT2 promotes lung adenocarcinoma progression through extracellular matrix dynamics and focal adhesion signaling

A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors

FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours

Synergistic effects of combined BET and FAK inhibition against Vestibular Schwannomas in NF2-related Schwannomatosis

ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

Focal adhesion kinase confers lenvatinib resistance in hepatocellular carcinoma via the regulation of lysine‐deficient kinase 1

FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors

p14ARF interacts with the focal adhesion kinase and protects cells from anoikis

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

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