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The Macrophage ‘Do not eat me’ signal, CD47, is a clinically validated cancer immunotherapy target

Annals of oncology, 2019-03, Vol.30 (3), p.486-489

2019

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Mechanism-based pharmacokinetic/pharmacodynamic model for troxacitabine-induced neutropenia in cancer patients

Cancer chemotherapy and pharmacology, 2011-05, Vol.67 (5), p.985-994

2011

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Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-α₅β₁ integrin monoclonal antibody (volociximab) in cancer patients

Cancer chemotherapy and pharmacology, 2010, Vol.65 (2), p.207-217

2010

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Translation of Anticancer Efficacy From Nonclinical Models to the Clinic

CPT: pharmacometrics and systems pharmacology, 2014-08, Vol.3 (8), p.1-4

2014

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Why drugs fail: of mice and men revisited

Clinical cancer research, 2001-02, Vol.7 (2), p.229-230

Takimoto, C H

2001

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Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency

Clinical cancer research, 1996-03, Vol.2 (3), p.477-481

1996

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High Inter- and Intrapatient Variation in 5-Fluorouracil Plasma Concentrations during a Prolonged Drug Infusion

Clinical cancer research, 1999-06, Vol.5 (6), p.1347-1352

1999

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Pharmacodynamics and pharmacokinetics of a 72-hour infusion of 9-aminocamptothecin in adult cancer patients

Journal of clinical oncology, 1997-04, Vol.15 (4), p.1492-1501

1997

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Human plasma carboxylesterase and butyrylcholinesterase enzyme activity : correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan

Cancer chemotherapy and pharmacology, 2001-04, Vol.47 (4), p.283-290

2001

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Phase II Trial of Paclitaxel by 96-Hour Continuous Infusion in Combination with Cisplatin for Patients with Advanced Non-Small Cell Lung Cancer

Clinical cancer research, 2000-07, Vol.6 (7), p.2670-2676

2000

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Paclitaxel by 96-hour continuous infusion in combination with cisplatin: a phase I trial in patients with advanced lung cancer

Journal of clinical oncology, 1997-02, Vol.15 (2), p.735-743

1997

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N-(phosphonacetyl)-L-aspartate and calcium leucovorin modulation of fluorouracil administered by constant rate and circadian pattern of infusion over 72 hours in metastatic gastrointestinal adenocarcinoma

Annals of oncology, 2001-11, Vol.12 (11), p.1581-1587

2001

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Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells

Cancer chemotherapy and pharmacology, 1997, Vol.40 (2), p.117-125

1997

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Enigma of Fluorouracil and Levamisole

JNCI : Journal of the National Cancer Institute, 1995-04, Vol.87 (7), p.471-473

Takimoto, C H

1995

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A Phase I Study of Raltitrexed, an Antifolate Thymidylate Synthase Inhibitor, in Adult Patients with Advanced Solid Tumors

Clinical cancer research, 1999-09, Vol.5 (9), p.2381-2391

1999

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Pharmacokinetics and pharmacodynamic effects of 5-fluorouracil given as a one-hour intravenous infusion

Cancer chemotherapy and pharmacology, 2001, Vol.47 (2), p.117-125

2001

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The Clinical Development of 9-Aminocamptothecin

Annals of the New York Academy of Sciences, 2000-01, Vol.922 (1), p.224-236

2000

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Effects of 9-aminocamptothecin on newly synthesized DNA in patient bone marrow samples

Clinical cancer research, 1995-11, Vol.1 (11), p.1345-1351

1995

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Phase I and Pharmacologic Study of Irinotecan Administered as a 96-Hour Infusion Weekly to Adult Cancer Patients

Journal of clinical oncology, 2000-02, Vol.18 (3), p.659-667

2000

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Phase I Trial of Sorafenib and Gemcitabine in Advanced Solid Tumors with an Expanded Cohort in Advanced Pancreatic Cancer

Clinical cancer research, 2006-01, Vol.12 (1), p.144-151

2006

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Phase I and Pharmacologic Study of 17-(Allylamino)-17-Demethoxygeldanamycin in Adult Patients With Solid Tumors

Journal of clinical oncology, 2005-03, Vol.23 (9), p.1885-1893

2005

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Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing

Cancer chemotherapy and pharmacology, 2015-03, Vol.75 (3), p.495-503

2015

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Phase I and Pharmacokinetic Trial of Weekly Oral Fluorouracil Given With Eniluracil and Low-Dose Leucovorin to Patients With Solid Tumors

Journal of clinical oncology, 2000-12, Vol.18 (23), p.3952-3963

2000

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Phase I and Pharmacokinetic Study of Pemetrexed Administered Every 3 Weeks to Advanced Cancer Patients With Normal and Impaired Renal Function

Journal of clinical oncology, 2006-02, Vol.24 (4), p.552-562

2006

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Phase I Pharmacokinetic and Pharmacodynamic Analysis of Unconjugated Soy Isoflavones Administered to Individuals with Cancer

Cancer epidemiology, biomarkers & prevention, 2003-11, Vol.12 (11), p.1213-1221

2003

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The Macrophage ‘Do not eat me’ signal, CD47, is a clinically validated cancer immunotherapy target

Mechanism-based pharmacokinetic/pharmacodynamic model for troxacitabine-induced neutropenia in cancer patients

Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-α₅β₁ integrin monoclonal antibody (volociximab) in cancer patients

Translation of Anticancer Efficacy From Nonclinical Models to the Clinic

Why drugs fail: of mice and men revisited

Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency

High Inter- and Intrapatient Variation in 5-Fluorouracil Plasma Concentrations during a Prolonged Drug Infusion

Pharmacodynamics and pharmacokinetics of a 72-hour infusion of 9-aminocamptothecin in adult cancer patients

Human plasma carboxylesterase and butyrylcholinesterase enzyme activity : correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan

Phase II Trial of Paclitaxel by 96-Hour Continuous Infusion in Combination with Cisplatin for Patients with Advanced Non-Small Cell Lung Cancer

Paclitaxel by 96-hour continuous infusion in combination with cisplatin: a phase I trial in patients with advanced lung cancer

N-(phosphonacetyl)-L-aspartate and calcium leucovorin modulation of fluorouracil administered by constant rate and circadian pattern of infusion over 72 hours in metastatic gastrointestinal adenocarcinoma

Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells

Enigma of Fluorouracil and Levamisole

A Phase I Study of Raltitrexed, an Antifolate Thymidylate Synthase Inhibitor, in Adult Patients with Advanced Solid Tumors

Pharmacokinetics and pharmacodynamic effects of 5-fluorouracil given as a one-hour intravenous infusion

The Clinical Development of 9-Aminocamptothecin

Effects of 9-aminocamptothecin on newly synthesized DNA in patient bone marrow samples

Phase I and Pharmacologic Study of Irinotecan Administered as a 96-Hour Infusion Weekly to Adult Cancer Patients

Phase I Trial of Sorafenib and Gemcitabine in Advanced Solid Tumors with an Expanded Cohort in Advanced Pancreatic Cancer

Phase I and Pharmacologic Study of 17-(Allylamino)-17-Demethoxygeldanamycin in Adult Patients With Solid Tumors

Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing

Phase I and Pharmacokinetic Trial of Weekly Oral Fluorouracil Given With Eniluracil and Low-Dose Leucovorin to Patients With Solid Tumors

Phase I and Pharmacokinetic Study of Pemetrexed Administered Every 3 Weeks to Advanced Cancer Patients With Normal and Impaired Renal Function

Phase I Pharmacokinetic and Pharmacodynamic Analysis of Unconjugated Soy Isoflavones Administered to Individuals with Cancer

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