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Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences

Current neuropharmacology, 2019-01, Vol.17 (10), p.926-946

2019

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Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

Pharmacology, biochemistry and behavior, 2014-11, Vol.126, p.43-49

2014

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Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study

Progress in neuro-psychopharmacology & biological psychiatry, 2021-06, Vol.108, p.110185-110185, Article 110185

2021

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Effect of dietary supplementation with Lactobacillus helveticus R0052 on seizure thresholds and antiseizure potency of sodium valproate in mice

Psychopharmacology, 2024-02, Vol.241 (2), p.327-340

2024

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Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats

Brain research bulletin, 2019-04, Vol.147, p.36-46

2019

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Sperm epigenetic mechanisms in autism spectrum disorders. The valproate case illustrates an enduring and systemic failure

Molecular psychiatry, 2024-04, Vol.29 (4), p.1163-1164

2024

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Persistent treatment resistance in genetic generalized epilepsy: A long‐term outcome study in a tertiary epilepsy center

Epilepsia (Copenhagen), 2020-11, Vol.61 (11), p.2452-2460

2020

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Lacosamide effects on placental carriers of essential compounds in comparison with valproate: Studies in perfused human placentas

Epilepsia (Copenhagen), 2022-11, Vol.63 (11), p.2949-2957

2022

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Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior

Molecular psychiatry, 2018-10, Vol.23 (10), p.2078-2089

2018

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Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders

Molecular psychiatry, 2021-11, Vol.26 (11), p.6789-6805

2021

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Metabolic and endocrine effects of valproic acid chronic treatment

Epilepsy research, 2013-11, Vol.107 (1), p.1-8

2013

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Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis

Neuroscience, 2019-05, Vol.406, p.580-593

2019

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GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

The European journal of neuroscience, 2023-02, Vol.57 (3), p.527-546

2023

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The Effect of Mood-Stabilizing Drugs on Cytokine Levels in Bipolar Disorder: A Systematic Review

Journal of affective disorders, 2016-10, Vol.203, p.364-373

2016

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X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition

Acta neuropathologica, 2022-09, Vol.144 (3), p.537-563

2022

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Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice

Epilepsia (Copenhagen), 2020-09, Vol.61 (9), p.2022-2034

2020

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Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy

Epilepsia (Copenhagen), 2023-01, Vol.64 (1), p.e1-e8

2023

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Neuroglia in the autistic brain: evidence from a preclinical model

Molecular autism, 2018-12, Vol.9 (1), p.66-66, Article 66

2018

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Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism

Behavioural brain research, 2022-06, Vol.428, p.113896-113896, Article 113896

2022

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Correlation among gut microbiota, fecal metabolites and autism-like behavior in an adolescent valproic acid-induced rat autism model

Behavioural brain research, 2022-01, Vol.417, p.113580-113580, Article 113580

2022

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The impact of antiseizure medication on bone heath: A systematic review of animal studies

Epilepsy research, 2024-02, Vol.200, p.107302, Article 107302

2024

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Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury

Journal of neurochemistry, 2020-08, Vol.154 (3), p.284-300

2020

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Neonatal Maternal Separation Impairs Prefrontal Cortical Myelination and Cognitive Functions in Rats Through Activation of Wnt Signaling

Cerebral cortex (New York, N.Y. 1991), 2017-05, Vol.27 (5), p.2871-2884

2017

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Astrocyte responses to postnatal erythropoietin and nano-erythropoietin treatments in a valproic acid-induced animal model of autism

Journal of chemical neuroanatomy, 2023-07, Vol.130, p.102257-102257, Article 102257

2023

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Acute valproate exposure affects proneural factor expression by increasing FOXO3 in the hippocampus of juvenile mice with a sex-based difference

Neuroscience letters, 2023-05, Vol.806, p.137226-137226, Article 137226

2023

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Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study

Effect of dietary supplementation with Lactobacillus helveticus R0052 on seizure thresholds and antiseizure potency of sodium valproate in mice

Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats

Sperm epigenetic mechanisms in autism spectrum disorders. The valproate case illustrates an enduring and systemic failure

Persistent treatment resistance in genetic generalized epilepsy: A long‐term outcome study in a tertiary epilepsy center

Lacosamide effects on placental carriers of essential compounds in comparison with valproate: Studies in perfused human placentas

Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior

Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders

Metabolic and endocrine effects of valproic acid chronic treatment

Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis

GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

The Effect of Mood-Stabilizing Drugs on Cytokine Levels in Bipolar Disorder: A Systematic Review

X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition

Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice

Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy

Neuroglia in the autistic brain: evidence from a preclinical model

Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism

Correlation among gut microbiota, fecal metabolites and autism-like behavior in an adolescent valproic acid-induced rat autism model

The impact of antiseizure medication on bone heath: A systematic review of animal studies

Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury

Neonatal Maternal Separation Impairs Prefrontal Cortical Myelination and Cognitive Functions in Rats Through Activation of Wnt Signaling

Astrocyte responses to postnatal erythropoietin and nano-erythropoietin treatments in a valproic acid-induced animal model of autism

Acute valproate exposure affects proneural factor expression by increasing FOXO3 in the hippocampus of juvenile mice with a sex-based difference

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