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Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers

Anesthesiology (Philadelphia), 2002-10, Vol.97 (4), p.827-836

2002

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Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Anesthesiology (Philadelphia), 2001, Vol.94 (1), p.63-73

2001

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A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

Clinical pharmacology and therapeutics, 1997-01, Vol.61 (1), p.45-58

1997

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The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Anesthesiology (Philadelphia), 1993-11, Vol.79 (5), p.881-892

1993

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Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

Anesthesiology (Philadelphia), 1997-10, Vol.87 (4), p.884-899

1997

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Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients

Anesthesiology (Philadelphia), 1998-03, Vol.88 (3), p.657-667

1998

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Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil

Clinical pharmacology and therapeutics, 1994-09, Vol.56 (3), p.261-271

1994

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Effects of thiopental on regional blood flows in the rat

Anesthesiology (Philadelphia), 1996-03, Vol.84 (3), p.596-604

1996

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Electroencephalographic effects of benzodiazepines. I. Choosing an electroencephalographic parameter to measure the effect of midazolam on the central nervous system

Clinical pharmacology and therapeutics, 1990-11, Vol.48 (5), p.544-554

1990

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Thiopental pharmacodynamics. I: Defining the pseudo-steady state-serum concentration-EEG effect relationship

Anesthesiology (Philadelphia), 1992-08, Vol.77 (2), p.226-236

1992

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Pharmacokinetics, pharmacodynamics, and relative pharmacokinetic/pharmacodynamic profiles of zaleplon and zolpidem

Clinical therapeutics, 2000-12, Vol.22 (12), p.1443-1461

2000

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The effect of increasing age on thiopental disposition and anesthetic requirement

Anesthesiology (Philadelphia), 1985-06, Vol.62 (6), p.714-724

1985

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Linearity of pharmacokinetics and model estimation of sufentanil

Anesthesiology (Philadelphia), 1995-12, Vol.83 (6), p.1194-1204

1995

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Comparison of a computer-assisted infusion versus intermittent bolus administration of alfentanil as a supplement to nitrous oxide for lower abdominal surgery

Anesthesiology (Philadelphia), 1988-06, Vol.68 (6), p.851-861

1988

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Population pharmacodynamic model for ketorolac analgesia

Clinical pharmacology and therapeutics, 1996-12, Vol.60 (6), p.619-635

1996

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Evaluating the accuracy of using population pharmacokinetic data to predict plasma concentrations of alfentanil

Anesthesiology (Philadelphia), 1988, Vol.68 (1), p.59-67

1988

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Absorption and bioavailability of oral transmucosal fentanyl citrate

Anesthesiology (Philadelphia), 1991-08, Vol.75 (2), p.223-229

1991

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A model for studying depth of anesthesia and acute tolerance to thiopental

Anesthesiology (Philadelphia), 1983-10, Vol.59 (4), p.301-308

1983

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Quantitation of depth of thiopental anesthesia in the rat

Anesthesiology (Philadelphia), 1996-02, Vol.84 (2), p.415-427

1996

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Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity

Anesthesiology (Philadelphia), 1996-06, Vol.84 (6), p.1411-1424

1996

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Thiopental pharmacodynamics. II: Quantitation of clinical and electroencephalographic depth of anesthesia

Anesthesiology (Philadelphia), 1992-08, Vol.77 (2), p.237-244

1992

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Plasma concentrations of alfentanil required to supplement nitrous oxide anesthesia for general surgery

Anesthesiology (Philadelphia), 1986-10, Vol.65 (4), p.362-373

1986

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Pharmacodynamic modeling of the electroencephalographic effects of flumazenil in healthy volunteers sedated with midazolam

Clinical pharmacology and therapeutics, 1995-11, Vol.58 (5), p.567-582

1995

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Plasma concentration clamping in the rat using a computer-controlled infusion pump

Pharmaceutical research, 1992-06, Vol.9 (6), p.800-807

1992

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Pentobarbital-morphine anesthetic interactions in terms of intensity of noxious stimulation required for arousal

Anesthesiology (Philadelphia), 1993-04, Vol.78 (4), p.744-749

1993

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Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers

Pharmacodynamics of orally administered sustained-release hydromorphone in humans

A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients

Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil

Effects of thiopental on regional blood flows in the rat

Electroencephalographic effects of benzodiazepines. I. Choosing an electroencephalographic parameter to measure the effect of midazolam on the central nervous system

Thiopental pharmacodynamics. I: Defining the pseudo-steady state-serum concentration-EEG effect relationship

Pharmacokinetics, pharmacodynamics, and relative pharmacokinetic/pharmacodynamic profiles of zaleplon and zolpidem

The effect of increasing age on thiopental disposition and anesthetic requirement

Linearity of pharmacokinetics and model estimation of sufentanil

Comparison of a computer-assisted infusion versus intermittent bolus administration of alfentanil as a supplement to nitrous oxide for lower abdominal surgery

Population pharmacodynamic model for ketorolac analgesia

Evaluating the accuracy of using population pharmacokinetic data to predict plasma concentrations of alfentanil

Absorption and bioavailability of oral transmucosal fentanyl citrate

A model for studying depth of anesthesia and acute tolerance to thiopental

Quantitation of depth of thiopental anesthesia in the rat

Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity

Thiopental pharmacodynamics. II: Quantitation of clinical and electroencephalographic depth of anesthesia

Plasma concentrations of alfentanil required to supplement nitrous oxide anesthesia for general surgery

Pharmacodynamic modeling of the electroencephalographic effects of flumazenil in healthy volunteers sedated with midazolam

Plasma concentration clamping in the rat using a computer-controlled infusion pump

Pentobarbital-morphine anesthetic interactions in terms of intensity of noxious stimulation required for arousal

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