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Drugging MYCN through an Allosteric Transition in Aurora Kinase A

Cancer cell, 2014-09, Vol.26 (3), p.414-427

2014

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The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

Annual review of biochemistry, 2011-07, Vol.80 (1), p.769-795

2011

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Nature (London), 2013-11, Vol.503 (7477), p.548-551

2013

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Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development

Neuron (Cambridge, Mass.), 2012-03, Vol.73 (6), p.1127-1142

2012

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Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

ACS chemical biology, 2015-01, Vol.10 (1), p.257-261

2015

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Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States

Cell chemical biology, 2017-12, Vol.24 (12), p.1455-1466.e14

2017

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The logic and design of analog-sensitive kinases and their small molecule inhibitors

Methods in enzymology, 2014, Vol.548, p.189-213

2014

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The unfolded protein response signals through high-order assembly of Ire1

Nature, 2009-02, Vol.457 (7230), p.687-693

2009

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A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

Nature (London), 2011-04, Vol.472 (7343), p.366-369

2011

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Nature chemical biology, 2008-11, Vol.4 (11), p.691-699

2008

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The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Biochemical journal, 2015-04, Vol.467 (1), p.47-62

2015

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Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

Science (American Association for the Advancement of Science), 2010-03, Vol.327 (5973), p.1638-1642

2010

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The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure

Nature structural & molecular biology, 2008-10, Vol.15 (10), p.1122-1124

2008

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Chemical genetic inhibition of DEAD-box proteins using covalent complementarity

Nucleic acids research, 2018-09, Vol.46 (17), p.8689-8699

2018

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surface on the androgen receptor that allosterically regulates coactivator binding

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (41), p.16074-16079

2007

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Chemical genetic strategy for targeting protein kinases based on covalent complementarity

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (37), p.15046-15052

2011

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Overcoming resistance to HER2 inhibitors through state-specific kinase binding

Nature chemical biology, 2016-11, Vol.12 (11), p.923-930

2016

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The Site-Specific Installation of Methyl-Lysine Analogs into Recombinant Histones

Cell, 2007-03, Vol.128 (5), p.1003-1012

2007

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The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

Nature chemical biology, 2010-02, Vol.6 (2), p.117-124

2010

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Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.1830-1839

2016

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Chemically reprogramming the phospho‐transfer reaction to crosslink protein kinases to their substrates

Protein science, 2019-03, Vol.28 (3), p.654-662

2019

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Structure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology

ACS chemical biology, 2013-09, Vol.8 (9), p.1931-1938

2013

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Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

Protein science, 2016-04, Vol.25 (4), p.826-839

2016

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Analog sensitive chemical inhibition of the DEAD‐box protein DDX3

Protein science, 2016-03, Vol.25 (3), p.638-649

2016

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Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

Molecular cell, 2008-11, Vol.32 (3), p.394-405

2008

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Drugging MYCN through an Allosteric Transition in Aurora Kinase A

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States

The logic and design of analog-sensitive kinases and their small molecule inhibitors

The unfolded protein response signals through high-order assembly of Ire1

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure

Chemical genetic inhibition of DEAD-box proteins using covalent complementarity

surface on the androgen receptor that allosterically regulates coactivator binding

Chemical genetic strategy for targeting protein kinases based on covalent complementarity

Overcoming resistance to HER2 inhibitors through state-specific kinase binding

The Site-Specific Installation of Methyl-Lysine Analogs into Recombinant Histones

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

Chemically reprogramming the phospho‐transfer reaction to crosslink protein kinases to their substrates

Structure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

Analog sensitive chemical inhibition of the DEAD‐box protein DDX3

Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

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