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Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

Clinical pharmacokinetics, 2010-08, Vol.49 (8), p.493-507

2010

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Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

Journal of pharmaceutical sciences, 2015-02, Vol.104 (2), p.705-713

2015

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A Near Infrared Light Triggered Hydrogenated Black TiO2 for Cancer Photothermal Therapy

Advanced healthcare materials, 2015-07, Vol.4 (10), p.1526-1536

2015

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Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N -Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans

The Journal of pharmacology and experimental therapeutics, 2021-11, Vol.379 (2), p.134-146

2021

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Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications

International journal of pharmaceutics, 2016-09, Vol.511 (1), p.586-598

2016

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Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice

International journal of pharmaceutics, 2016-02, Vol.498 (1-2), p.119-129

2016

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Enhanced Solubility and Bioavailability of Naringenin via Liposomal Nanoformulation: Preparation and In Vitro and In Vivo Evaluations

AAPS PharmSciTech, 2017-04, Vol.18 (3), p.586-594

2017

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A brief history of IL-9

The Journal of immunology (1950), 2011-03, Vol.186 (6), p.3283-3288

2011

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Enhanced Oral Delivery of Curcumin from N-trimethyl Chitosan Surface-Modified Solid Lipid Nanoparticles: Pharmacokinetic and Brain Distribution Evaluations

Pharmaceutical research, 2015-02, Vol.32 (2), p.389-402

2015

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CN128: A New Orally Active Hydroxypyridinone Iron Chelator

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.4215-4226

2020

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Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation

International journal of pharmaceutics, 2020-05, Vol.581, p.119291, Article 119291

2020

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Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations

International journal of pharmaceutics, 2017-03, Vol.519 (1-2), p.1-10

2017

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Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Journal of pharmacokinetics and pharmacodynamics, 2012-02, Vol.39 (1), p.67-86

2012

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The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8+ T-cell responses: The immunological consequences of the biodistribution profile

Journal of controlled release, 2016-10, Vol.239, p.107-117

2016

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Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans

Toxicology and applied pharmacology, 2018-07, Vol.351, p.32-45

2018

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Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy

The AAPS journal, 2016-09, Vol.18 (5), p.1117-1130

2016

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Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model

Drug metabolism and disposition, 2021-04, Vol.49 (4), p.330-336

2021

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Preparation of liposomes containing IFN-gamma and their potentials in cancer immunotherapy: In vitro and in vivo studies in a colon cancer mouse model

Life sciences (1973), 2021-01, Vol.264, p.118605, Article 118605

2021

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GPER mediates decreased chemosensitivity via regulation of ABCG2 expression and localization in tamoxifen-resistant breast cancer cells

Molecular and cellular endocrinology, 2020-04, Vol.506, p.110762-110762, Article 110762

2020

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Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects

Neuroscience, 2017-12, Vol.367, p.85-97

2017

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Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1170-1177

2012

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In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution

The Journal of pharmacology and experimental therapeutics, 2019-11, Vol.371 (2), p.327-338

2019

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Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid

International journal of pharmaceutics, 2016-08, Vol.510 (1), p.350-358

2016

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Fluorescent carbon dot-gated multifunctional mesoporous silica nanocarriers for redox/enzyme dual-responsive targeted and controlled drug delivery and real-time bioimaging

European journal of pharmaceutics and biopharmaceutics, 2017-08, Vol.117, p.105-115

2017

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Modulation of the Biophysical Properties of Bifunctional Antibodies as a Strategy for Mitigating Poor Pharmacokinetics

Biochemistry (Easton), 2019-07, Vol.58 (28), p.3116-3132

2019

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Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

A Near Infrared Light Triggered Hydrogenated Black TiO2 for Cancer Photothermal Therapy

Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N -Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans

Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications

Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice

Enhanced Solubility and Bioavailability of Naringenin via Liposomal Nanoformulation: Preparation and In Vitro and In Vivo Evaluations

A brief history of IL-9

Enhanced Oral Delivery of Curcumin from N-trimethyl Chitosan Surface-Modified Solid Lipid Nanoparticles: Pharmacokinetic and Brain Distribution Evaluations

CN128: A New Orally Active Hydroxypyridinone Iron Chelator

Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation

Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8+ T-cell responses: The immunological consequences of the biodistribution profile

Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans

Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy

Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model

Preparation of liposomes containing IFN-gamma and their potentials in cancer immunotherapy: In vitro and in vivo studies in a colon cancer mouse model

GPER mediates decreased chemosensitivity via regulation of ABCG2 expression and localization in tamoxifen-resistant breast cancer cells

Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects

Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics

In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution

Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid

Fluorescent carbon dot-gated multifunctional mesoporous silica nanocarriers for redox/enzyme dual-responsive targeted and controlled drug delivery and real-time bioimaging

Modulation of the Biophysical Properties of Bifunctional Antibodies as a Strategy for Mitigating Poor Pharmacokinetics

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