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Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.1108-1117

2014

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Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance

PloS one, 2015-08, Vol.10 (8), p.e0136486

2015

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Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas aeruginosa infection via inhibition of toxin translocation by the type III secretion system

Antimicrobial agents and chemotherapy, 2024-10, Vol.68 (10), p.e0069424

2024

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Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B

PLoS biology, 2019-06, Vol.17 (6), p.e3000311-e3000311

2019

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Targeting NLRP3 and Staphylococcal pore‐forming toxin receptors in human‐induced pluripotent stem cell‐derived macrophages

Journal of leukocyte biology, 2020-09, Vol.108 (3), p.967-981

2020

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In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.892-900

2014

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Targeting of Alpha-Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model

The Journal of infectious diseases, 2010-10, Vol.202 (7), p.1050-1058

2010

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Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus α-Hemolysin

Journal of molecular biology, 2013-05, Vol.425 (10), p.1641-1654

2013

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Baicalin Protects Mice From Staphylococcus aureus Pneumonia Via Inhibition of the Cytolytic Activity of α-Hemolysin

The Journal of infectious diseases, 2012-07, Vol.206 (2), p.292-301

2012

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18β-Glycyrrhetinic Acid Inhibits Methicillin-Resistant Staphylococcus aureus Survival and Attenuates Virulence Gene Expression

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.241-247

2013

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Statin-conferred enhanced cellular resistance against bacterial pore-forming toxins in airway epithelial cells

American journal of respiratory cell and molecular biology, 2015-11, Vol.53 (5), p.689-702

2015

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A pH-sensitive eosin-block copolymer delivers proteins intracellularly

Chemical communications (Cambridge, England), 2020-11, Vol.56 (91), p.1427-1421

2020

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Anti-Alpha-Hemolysin Monoclonal Antibodies Mediate Protection against Staphylococcus aureus Pneumonia

Infection and Immunity, 2009-07, Vol.77 (7), p.2712-2718

2009

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Human Monoclonal Antibodies Directed against Toxins A and B Prevent Clostridium difficile-Induced Mortality in Hamsters

Infection and Immunity, 2006-11, Vol.74 (11), p.6339-6347

2006

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Linezolid Attenuates Lethal Lung Damage during Postinfluenza Methicillin-Resistant Staphylococcus aureus Pneumonia

Infection and immunity, 2019-10, Vol.87 (10)

2019

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Activity of the Pore-Forming Virulence Factor Listeriolysin O Is Reversibly Inhibited by Naturally Occurring S-Glutathionylation

Infection and immunity, 2017-04, Vol.85 (4)

2017

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Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self‐assembly of α‐hemolysin

Journal of applied microbiology, 2015-03, Vol.118 (3), p.753-763

2015

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Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin

Antimicrobial agents and chemotherapy, 2016-11, Vol.60 (11), p.6471-6482

2016

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Aloe-emodin Attenuates Staphylococcus aureus Pathogenicity by Interfering With the Oligomerization of α-Toxin

Frontiers in cellular and infection microbiology, 2019-05, Vol.9, p.157-157

2019

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Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (50), p.E4904-E4912

2013

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Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB)

Bioorganic & medicinal chemistry letters, 2018-12, Vol.28 (23-24), p.3601-3605

2018

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A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

The Journal of biological chemistry, 2016-10, Vol.291 (41), p.21596-21606

2016

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A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model

The Journal of biological chemistry, 2015-03, Vol.290 (10), p.6584-6595

2015

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Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency

Clinical and Vaccine Immunology, 2012-03, Vol.19 (3), p.377-385

2012

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Through the Looking Glass, Mechanistic Insights from Enantiomeric Human Defensins

The Journal of biological chemistry, 2009-10, Vol.284 (42), p.29180-29192

2009

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Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia

Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance

Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas aeruginosa infection via inhibition of toxin translocation by the type III secretion system

Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B

Targeting NLRP3 and Staphylococcal pore‐forming toxin receptors in human‐induced pluripotent stem cell‐derived macrophages

In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

Targeting of Alpha-Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model

Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus α-Hemolysin

Baicalin Protects Mice From Staphylococcus aureus Pneumonia Via Inhibition of the Cytolytic Activity of α-Hemolysin

18β-Glycyrrhetinic Acid Inhibits Methicillin-Resistant Staphylococcus aureus Survival and Attenuates Virulence Gene Expression

Statin-conferred enhanced cellular resistance against bacterial pore-forming toxins in airway epithelial cells

A pH-sensitive eosin-block copolymer delivers proteins intracellularly

Anti-Alpha-Hemolysin Monoclonal Antibodies Mediate Protection against Staphylococcus aureus Pneumonia

Human Monoclonal Antibodies Directed against Toxins A and B Prevent Clostridium difficile-Induced Mortality in Hamsters

Linezolid Attenuates Lethal Lung Damage during Postinfluenza Methicillin-Resistant Staphylococcus aureus Pneumonia

Activity of the Pore-Forming Virulence Factor Listeriolysin O Is Reversibly Inhibited by Naturally Occurring S-Glutathionylation

Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self‐assembly of α‐hemolysin

Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin

Aloe-emodin Attenuates Staphylococcus aureus Pathogenicity by Interfering With the Oligomerization of α-Toxin

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB)

A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model

Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency

Through the Looking Glass, Mechanistic Insights from Enantiomeric Human Defensins

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