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Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci

Nature communications, 2022-04, Vol.13 (1), p.1841-1841, Article 1841

2022

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Panel of human cell lines with human/mouse artificial chromosomes

Scientific reports, 2022-02, Vol.12 (1), p.3009-3009, Article 3009

2022

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The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

The Journal of experimental medicine, 2011-02, Vol.208 (2), p.285-294

2011

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R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

Human molecular genetics, 2008-05, Vol.17 (9), p.1278-1291

2008

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Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model

Scientific reports, 2023-03, Vol.13 (1), p.4360-4360, Article 4360

2023

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Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery

Scientific reports, 2022-12, Vol.12 (1), p.21790-21790, Article 21790

2022

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Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

Science (American Association for the Advancement of Science), 2005-08, Vol.309 (5738), p.1256-1259

2005

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Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism

American journal of physiology. Renal physiology, 2005-11, Vol.289 (5), p.F1088-F1095

2005

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Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

Human molecular genetics, 2013-02, Vol.22 (3), p.578-592

2013

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Craniofacial malformation in R-spondin2 knockout mice

Biochemical and biophysical research communications, 2009-04, Vol.381 (3), p.453-458

2009

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Identification of osteoblast stimulating factor 5 as a negative regulator in the B-lymphopoietic niche

Experimental hematology, 2015-11, Vol.43 (11), p.963-973.e4

2015

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Functional redundancy of the Notch gene family during mouse embryogenesis: Analysis of Notch gene expression in Notch3-deficient mice

Biochemical and biophysical research communications, 2005-06, Vol.331 (4), p.1154-1162

2005

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A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

Biochemical and biophysical research communications, 2011-11, Vol.415 (3), p.439-444

2011

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Double Trans-Chromosomic Mice: Maintenance of Two Individual Human Chromosome Fragments Containing Ig Heavy and κ Loci and Expression of Fully Human Antibodies

Proceedings of the National Academy of Sciences - PNAS, 2000-01, Vol.97 (2), p.722-727

2000

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Novel anticarcinoembryonic antigen antibody–drug conjugate has antitumor activity in the existence of soluble antigen

Cancer medicine (Malden, MA), 2017-04, Vol.6 (4), p.798-808

2017

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novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region

Transgenic research, 2014-06, Vol.23 (3), p.441-453

2014

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Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

Nature biotechnology, 2000-10, Vol.18 (10), p.1086-1090

2000

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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

The Journal of clinical investigation, 2004-02, Vol.113 (4), p.561-568

2004

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The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders

Scientific reports, 2016-01, Vol.6 (1), p.18849-18849, Article 18849

2016

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R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation

Blood advances, 2024-02, Vol.8 (3), p.725-731

2024

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Targeted deletion of the tybe IIb Na+-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality

Biochemical and biophysical research communications, 2009-04, Vol.381 (4), p.482-486

2009

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Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice

Journal of human genetics, 2001-10, Vol.46 (10), p.600-603

2001

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Estrogen‐inducible sFRP5 inhibits early B‐lymphopoiesis in vivo, but not during pregnancy

European journal of immunology, 2015-05, Vol.45 (5), p.1390-1401

2015

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A new model mouse for Duchenne muscular dystrophy produced by 2.4 Mb deletion of dystrophin gene using Cre- loxP recombination system

Biochemical and biophysical research communications, 2005-03, Vol.328 (2), p.507-516

2005

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Production of a Diverse Repertoire of Human Antibodies in Genetically Engineered Mice

MICROBIOLOGY and IMMUNOLOGY, 1998, Vol.42(3), pp.143-150

1998

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Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci

Panel of human cell lines with human/mouse artificial chromosomes

The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model

Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery

Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

Craniofacial malformation in R-spondin2 knockout mice

Identification of osteoblast stimulating factor 5 as a negative regulator in the B-lymphopoietic niche

Functional redundancy of the Notch gene family during mouse embryogenesis: Analysis of Notch gene expression in Notch3-deficient mice

A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

Double Trans-Chromosomic Mice: Maintenance of Two Individual Human Chromosome Fragments Containing Ig Heavy and κ Loci and Expression of Fully Human Antibodies

Novel anticarcinoembryonic antigen antibody–drug conjugate has antitumor activity in the existence of soluble antigen

novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region

Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders

R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation

Targeted deletion of the tybe IIb Na+-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality

Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice

Estrogen‐inducible sFRP5 inhibits early B‐lymphopoiesis in vivo, but not during pregnancy

A new model mouse for Duchenne muscular dystrophy produced by 2.4 Mb deletion of dystrophin gene using Cre- loxP recombination system

Production of a Diverse Repertoire of Human Antibodies in Genetically Engineered Mice

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