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Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1563-1578

2010

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Novel 5-substituted, 2,4-diaminofuro[2,3- d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity

Bioorganic & medicinal chemistry, 2005-09, Vol.13 (18), p.5475-5491

2005

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2,4-Diamino-5-deaza-6-Substituted Pyrido[2,3-d]pyrimidine Antifolates as Potent and Selective Nonclassical Inhibitors of Dihydrofolate Reductases

Journal of medicinal chemistry, 1996-03, Vol.39 (7), p.1438-1446

1996

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Synergistic interactions among antifolates

Pharmacology & therapeutics (Oxford), 2000-03, Vol.85 (3), p.183-190

Kisliuk, Roy L.

2000

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Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents

Bioorganic & medicinal chemistry, 2012-07, Vol.20 (14), p.4217-4225

2012

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Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents

Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3437-3443

1993

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Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogs of methotrexate and tetrahydrofolic acid

Journal of medicinal chemistry, 1990-02, Vol.33 (2), p.673-677

1990

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Novel nonclassical inhibitors of glycinamide ribonucleotide formyltransferase: 10-Formyl and 10-hydroxymethyl derivatives of 5,8,10-trideazapteroic acid

Journal of molecular recognition, 1996-03, Vol.9 (2), p.169-174

1996

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Antitumor efficacy of classical non-polyglutamylatable antifolates that inhibit dihydrofolate reductase

Advances in experimental medicine and biology, 1993, Vol.338, p.663

1993

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Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase

Journal of medicinal chemistry, 1989-06, Vol.32 (6), p.1277-1283

1989

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Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts

Cancer research (Chicago, Ill.), 1989, Vol.49 (1), p.158-163

1989

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Synthesis and biological evaluation of poly-.gamma.-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin

Journal of medicinal chemistry, 1988-01, Vol.31 (1), p.181-185

1988

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Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin

Journal of medicinal chemistry, 1982-10, Vol.25 (10), p.1227-1230

1982

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Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative

Journal of medicinal chemistry, 1988-01, Vol.31 (1), p.150-153

1988

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Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin

Journal of medicinal chemistry, 1986-09, Vol.29 (9), p.1786-1789

1986

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Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin

Journal of medicinal chemistry, 1986-06, Vol.29 (6), p.1056-1061

1986

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Syntheses and antifolate activity of 5-methyl-5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid

Journal of medicinal chemistry, 1986-06, Vol.29 (6), p.1080-1087

1986

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Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins

Journal of medicinal chemistry, 1984-03, Vol.27 (3), p.376-380

1984

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Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs

Journal of medicinal chemistry, 1974-11, Vol.17 (11), p.1212-1216

1974

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Folate analogs altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin

Journal of medicinal chemistry, 1980-08, Vol.23 (8), p.899-903

1980

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Folate analogs altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds

Journal of medicinal chemistry, 1981-09, Vol.24 (9), p.1068-1073

1981

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Further studies of stereospecificity at carbon 6 for membrane transport of tetrahydrofolates: Diastereoisomers of 5-methyltetrahydrofolates as competitive inhibitors of transport of methotrexate in L1210 cells

Biochemical pharmacology, 1982-04, Vol.31 (8), p.1527-1530

1982

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Diastereoisomers of formaldehyde derivatives of tetrahydrofolic acid and tetrahydroaminopterin

Journal of medicinal chemistry, 1969-01, Vol.12 (1), p.49-51

1969

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Pharmacologic aspects of homofolate derivatives in relation to amethopterin-resistant murine leukemia

Cancer research (Chicago, Ill.), 1966-11, Vol.26 (11), p.2374

1966

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Methotrexate analogs. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogs

Journal of medicinal chemistry, 1977-10, Vol.20 (10), p.1323-1327

1977

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Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

Novel 5-substituted, 2,4-diaminofuro[2,3- d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity

2,4-Diamino-5-deaza-6-Substituted Pyrido[2,3-d]pyrimidine Antifolates as Potent and Selective Nonclassical Inhibitors of Dihydrofolate Reductases

Synergistic interactions among antifolates

Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents

Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents

Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogs of methotrexate and tetrahydrofolic acid

Novel nonclassical inhibitors of glycinamide ribonucleotide formyltransferase: 10-Formyl and 10-hydroxymethyl derivatives of 5,8,10-trideazapteroic acid

Antitumor efficacy of classical non-polyglutamylatable antifolates that inhibit dihydrofolate reductase

Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase

Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts

Synthesis and biological evaluation of poly-.gamma.-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin

Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin

Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative

Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin

Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin

Syntheses and antifolate activity of 5-methyl-5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid

Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins

Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs

Folate analogs altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin

Folate analogs altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds

Further studies of stereospecificity at carbon 6 for membrane transport of tetrahydrofolates: Diastereoisomers of 5-methyltetrahydrofolates as competitive inhibitors of transport of methotrexate in L1210 cells

Diastereoisomers of formaldehyde derivatives of tetrahydrofolic acid and tetrahydroaminopterin

Pharmacologic aspects of homofolate derivatives in relation to amethopterin-resistant murine leukemia

Methotrexate analogs. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogs

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