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Adamts-1 Is Essential for the Development and Function of the Urogenital System

Biology of reproduction, 2004-04, Vol.70 (4), p.1096-1105

2004

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ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

Human molecular genetics, 2003-02, Vol.12 (3), p.247-255

2003

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Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

Neurobiology of disease, 2003-12, Vol.14 (3), p.349-356

2003

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Characterization of the type I interferon locus and identification of novel genes

Genomics (San Diego, Calif.), 2004-08, Vol.84 (2), p.331-345

2004

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine

Cell, 1999-09, Vol.98 (5), p.597-608

1999

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Animal Models in the Study of the Biological Function of Genes on Human Chromosome 21 and Their Role in the Pathophysiology of Down Syndrome

Human molecular genetics, 1997-01, Vol.6 (10), p.1713-1727

1997

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Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

The Journal of biological chemistry, 1998-08, Vol.273 (35), p.22528-22536

1998

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Transformation induced by Ewing's sarcoma associated EWS FLI-1 is suppressed by KRAB FLI-1

British journal of cancer, 2003-01, Vol.88 (1), p.137-145

2003

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A Null Mutation in the Gene Encoding a Type I Interferon Receptor Component Eliminates Antiproliferative and Antiviral Responses to Interferons α and β and Alters Macrophage responses

Proceedings of the National Academy of Sciences - PNAS, 1995-11, Vol.92 (24), p.11284-11288

1995

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GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

Journal of leukocyte biology, 2009-08, Vol.86 (2), p.411-421

2009

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The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties

Blood, 2001-01, Vol.97 (2), p.473-482

2001

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Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells

The EMBO journal, 2002-08, Vol.21 (15), p.4081-4093

2002

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Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs

Genome research, 2001-08, Vol.11 (8), p.1327-1334

2001

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A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons

The Journal of biological chemistry, 1994-05, Vol.269 (19), p.14088-14093

1994

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The chromosome 21 transcription factor ETS2 transactivates the β- APP promoter: implications for Down syndrome

Biochimica et biophysica acta, 2003-07, Vol.1628 (2), p.105-110

2003

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Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis

Nephrology, dialysis, transplantation, 2005-02, Vol.20 (2), p.419-423

2005

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Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus

Arthritis research & therapy, 2009-01, Vol.11 (4), p.R112-R112, Article R112

2009

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Blocking monoclonal antibodies specific for mouse IFN-alpha/beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection

Journal of interferon & cytokine research, 2006-11, Vol.26 (11), p.804-819

2006

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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

Nature Immunology, 2006-02, Vol.7 (2), p.148-155

2006

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Down syndrome and mouse models

Current opinion in genetics & development, 1998-06, Vol.8 (3), p.316-321

1998

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Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression

Biochemical journal, 2002-07, Vol.365 (Pt 2), p.355-367

2002

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Oncofetal expression of the human intestinal mucin glycoprotein antigens in gastrointestinal epithelium defined by monoclonal antibodies

International journal of cancer, 1991-05, Vol.48 (3), p.355-363

1991

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Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

Nature Immunology, 2006-01, Vol.7 (1), p.33-39

2006

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Overview. Gene knockouts

Methods in molecular biology (Clifton, N.J.), 2001, Vol.158, p.1

2001

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Macrophage lineage phenotypes and osteoclastogenesis—Complexity in the control by GM-CSF and TGF-β

Bone (New York, N.Y.), 2007-02, Vol.40 (2), p.323-336

2007

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Adamts-1 Is Essential for the Development and Function of the Urogenital System

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

Characterization of the type I interferon locus and identification of novel genes

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine

Animal Models in the Study of the Biological Function of Genes on Human Chromosome 21 and Their Role in the Pathophysiology of Down Syndrome

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

Transformation induced by Ewing's sarcoma associated EWS FLI-1 is suppressed by KRAB FLI-1

A Null Mutation in the Gene Encoding a Type I Interferon Receptor Component Eliminates Antiproliferative and Antiviral Responses to Interferons α and β and Alters Macrophage responses

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties

Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells

Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs

A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons

The chromosome 21 transcription factor ETS2 transactivates the β- APP promoter: implications for Down syndrome

Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis

Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus

Blocking monoclonal antibodies specific for mouse IFN-alpha/beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

Down syndrome and mouse models

Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression

Oncofetal expression of the human intestinal mucin glycoprotein antigens in gastrointestinal epithelium defined by monoclonal antibodies

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

Overview. Gene knockouts

Macrophage lineage phenotypes and osteoclastogenesis—Complexity in the control by GM-CSF and TGF-β

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