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The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Expert opinion on drug metabolism & toxicology, 2010-11, Vol.6 (11), p.1333-1346

2010

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Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity

Toxicology (Amsterdam), 1996-10, Vol.113 (1), p.23-30

1996

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Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism

Chemico-biological interactions, 2001-06, Vol.135, p.239-248

2001

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Characterization of the Reactivity, Regioselectivity, and Stereoselectivity of the Reactions of Butadiene Monoxide with Valinamide and the N-Terminal Valine of Mouse and Rat Hemoglobin

Chemical research in toxicology, 1999-08, Vol.12 (8), p.679-689

1999

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A Comprehensive Structural Analysis of Hemoglobin Adducts Formed after in Vitro Exposure of Erythrocytes to Butadiene Monoxide

Chemical research in toxicology, 2000-11, Vol.13 (11), p.1103-1113

2000

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Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene

Drug metabolism and disposition, 2003-08, Vol.31 (8), p.986-992

2003

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Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.1148-1155

2009

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Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse

Drug metabolism and disposition, 2003-06, Vol.31 (6), p.718

2003

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Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver

Drug metabolism and disposition, 1997-08, Vol.25 (8), p.1013

1997

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Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Toxicology and applied pharmacology, 2009-05, Vol.236 (3), p.358-365

2009

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The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens

Molecular cancer therapeutics, 2002-11, Vol.1 (13), p.1211

2002

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Glutathione conjugation of perchloroethylene in rats and mice in vitro : Sex-, species-, and tissue-dependent differences

Toxicology and applied pharmacology, 1998-05, Vol.150 (1), p.49-57

1998

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Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences

Drug metabolism and disposition, 1998-01, Vol.26 (1), p.12

1998

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Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

Archives of biochemistry and biophysics, 1994-06, Vol.311 (2), p.342-349

1994

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Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Chemical research in toxicology, 2001-12, Vol.14 (12), p.1590-1595

2001

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Isoform distinct time-, dose-, and castration-dependent alterations in flavin-containing monooxygenase expression in mouse liver after 2,3,7,8-tetrachlorodibenzo- p-dioxin treatment

Biochemical pharmacology, 2010-05, Vol.79 (9), p.1345-1351

2010

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Mechanisms of 1,3-butadiene oxidations to butadiene monoxide and crotonaldehyde by mouse liver microsomes and chloroperoxidase

Archives of biochemistry and biophysics, 1991-04, Vol.286 (1), p.244-251

1991

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Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Chemical research in toxicology, 2004-06, Vol.17 (6), p.819-826

2004

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Metabolism of 3-butene-1,2-diol in B6C3F1 mice. Evidence for involvement of alcohol dehydrogenase and cytochrome p450

Drug metabolism and disposition, 1998-09, Vol.26 (9), p.914

1998

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Metabolism of butadiene monoxide by freshly isolated hepatocytes from mice and rats: different partitioning between oxidative, hydrolytic, and conjugation pathways

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.830

2001

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L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2252-2260

2008

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Methionine S-Oxidation in Human and Rabbit Liver Microsomes: Evidence for a High-Affinity Methionine S-Oxidase Activity That Is Distinct from Flavin-Containing Monooxygenase 3

Archives of biochemistry and biophysics, 1999-07, Vol.367 (2), p.322-332

1999

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L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.809-817

2008

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Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

The Journal of pharmacology and experimental therapeutics, 2002-04, Vol.301 (1), p.77-86

2002

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Oxidation of 3-Butene-1,2-diol by Alcohol Dehydrogenase

Chemical research in toxicology, 1996-10, Vol.9 (7), p.1127-1134

1996

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The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity

Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism

Characterization of the Reactivity, Regioselectivity, and Stereoselectivity of the Reactions of Butadiene Monoxide with Valinamide and the N-Terminal Valine of Mouse and Rat Hemoglobin

A Comprehensive Structural Analysis of Hemoglobin Adducts Formed after in Vitro Exposure of Erythrocytes to Butadiene Monoxide

Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene

Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse

Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver

Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens

Glutathione conjugation of perchloroethylene in rats and mice in vitro : Sex-, species-, and tissue-dependent differences

Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences

Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Isoform distinct time-, dose-, and castration-dependent alterations in flavin-containing monooxygenase expression in mouse liver after 2,3,7,8-tetrachlorodibenzo- p-dioxin treatment

Mechanisms of 1,3-butadiene oxidations to butadiene monoxide and crotonaldehyde by mouse liver microsomes and chloroperoxidase

Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Metabolism of 3-butene-1,2-diol in B6C3F1 mice. Evidence for involvement of alcohol dehydrogenase and cytochrome p450

Metabolism of butadiene monoxide by freshly isolated hepatocytes from mice and rats: different partitioning between oxidative, hydrolytic, and conjugation pathways

L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Methionine S-Oxidation in Human and Rabbit Liver Microsomes: Evidence for a High-Affinity Methionine S-Oxidase Activity That Is Distinct from Flavin-Containing Monooxygenase 3

L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

Oxidation of 3-Butene-1,2-diol by Alcohol Dehydrogenase

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