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Insulin-Degrading Enzyme Regulates the Levels of Insulin, Amyloid β-Protein, and the β-Amyloid Precursor Protein Intracellular Domain in vivo

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (7), p.4162-4167

2003

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Amyloid-β Peptide Levels in Brain Are Inversely Correlated with Insulysin Activity Levels in vivo

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (10), p.6221-6226

2003

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The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

Neuron (Cambridge, Mass.), 2004-10, Vol.44 (2), p.227-238

2004

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Altered Metabolism of Familial Alzheimer's Disease-Linked Amyloid Precursor Protein Variants in Yeast Artificial Chromosome Transgenic Mice

Human molecular genetics, 1997-09, Vol.6 (9), p.1535-1541

1997

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Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy

The FASEB journal, 2005-09, Vol.19 (11), p.1549-1551

2005

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Behavioral and neurobiological markers of Alzheimer’s disease in Ts65Dn mice: effects of estrogen

Neurobiology of aging, 2004-08, Vol.25 (7), p.873-884

2004

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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

The FASEB journal, 2001-01, Vol.15 (1), p.16-18

2001

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Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy

The FASEB journal, 2007-08, Vol.21 (10), p.2520-2527

2007

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

The Journal of biological chemistry, 2003-01, Vol.278 (4), p.2081-2084

2003

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Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

The EMBO journal, 2006-01, Vol.25 (2), p.420-431

2006

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Accumulation of β-Amyloid fibrils in pancreas of transgenic mice

Neurobiology of aging, 1996-03, Vol.17 (2), p.215-222

1996

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Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

Biochemical Society transactions, 2005-11, Vol.33 (Pt 5), p.1101

2005

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

Neuron (Cambridge, Mass.), 1996-11, Vol.17 (5), p.1005-1013

1996

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Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (26), p.11062-11067

2007

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Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

Molecular cell, 2003-10, Vol.12 (4), p.841-849

2003

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice

The Journal of neuroscience, 2007-07, Vol.27 (29), p.7817-7826

2007

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The Diarylheptanoid (+)-aR,11S-Myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule-Associated Protein Tau

Journal of natural products (Washington, D.C.), 2011-01, Vol.74 (1), p.38-44

2011

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HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

The FASEB journal, 2006-04, Vol.20 (6), p.753-755

2006

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Substrate-targeting γ-secretase modulators

Nature (London), 2008-06, Vol.453 (7197), p.925-929

2008

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Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa

ACS chemical neuroscience, 2012-11, Vol.3 (11), p.941-951

2012

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PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation

The FASEB journal, 2007-08, Vol.21 (10), p.2335-2342

2007

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Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

Neuron (Cambridge, Mass.), 1995-11, Vol.15 (5), p.1203-1218

1995

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Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD)

Neurobiology of disease, 2006-08, Vol.23 (2), p.273-280

2006

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Dietary changes improve survival of CFTR S489X homozygous mutant mouse

American journal of physiology. Lung cellular and molecular physiology, 1995-11, Vol.269 (5), p.625-L630

1995

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Insulin-Degrading Enzyme Regulates the Levels of Insulin, Amyloid β-Protein, and the β-Amyloid Precursor Protein Intracellular Domain in vivo

Amyloid-β Peptide Levels in Brain Are Inversely Correlated with Insulysin Activity Levels in vivo

The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

Altered Metabolism of Familial Alzheimer's Disease-Linked Amyloid Precursor Protein Variants in Yeast Artificial Chromosome Transgenic Mice

Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy

Behavioral and neurobiological markers of Alzheimer’s disease in Ts65Dn mice: effects of estrogen

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

Accumulation of β-Amyloid fibrils in pancreas of transgenic mice

Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice

The Diarylheptanoid (+)-aR,11S-Myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule-Associated Protein Tau

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

Substrate-targeting γ-secretase modulators

Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa

PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD)

Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD)

Dietary changes improve survival of CFTR S489X homozygous mutant mouse

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