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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Immunity (Cambridge, Mass.), 2016-03, Vol.44 (3), p.597-608

2016

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IFI16 is an innate immune sensor for intracellular DNA

Nature immunology, 2010-11, Vol.11 (11), p.997

2010

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Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

Journal of neuroinflammation, 2012-10, Vol.9 (1), p.230-230, Article 698

2012

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SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration

International journal of molecular sciences, 2022-01, Vol.23 (3), p.1606

2022

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Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule

The Journal of immunology (1950), 2010-10, Vol.185 (7), p.4261-4271

2010

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Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

PLoS pathogens, 2013-02, Vol.9 (2), p.e1003183

2013

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The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling

Biochemical pharmacology, 2010-12, Vol.80 (12), p.1981-1991

2010

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Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

The Journal of experimental medicine, 2005-03, Vol.201 (6), p.1007-1018

2005

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Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner

Journal of Virology, 2005-10, Vol.79 (20), p.12944-12951

2005

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Polyinosinic Acid Is a Ligand for Toll-like Receptor 3

The Journal of biological chemistry, 2007-08, Vol.282 (34), p.24759-24766

2007

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Vaccinia Virus Protein A52R Activates p38 Mitogen-activated Protein Kinase and Potentiates Lipopolysaccharide-induced Interleukin-10

The Journal of biological chemistry, 2005-09, Vol.280 (35), p.30838-30844

2005

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Toll-like receptor 2–dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival

The Journal of biological chemistry, 2019-11, Vol.294 (45), p.17031-17042

2019

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CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages

The Journal of biological chemistry, 2021-12, Vol.297 (6), p.101417-101417, Article 101417

2021

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SARM1 regulates NAD+-linked metabolism and select immune genes in macrophages

The Journal of biological chemistry, 2024-02, Vol.300 (2), p.105620-105620, Article 105620

2024

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DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

Glia, 2015-05, Vol.63 (5), p.812-825

2015

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A novel anti-viral role for STAT3 in IFN-α signalling responses

Cellular and molecular life sciences : CMLS, 2017-05, Vol.74 (9), p.1755-1764

2017

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The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4

Journal of leukocyte biology, 2014-09, Vol.96 (3), p.427-436

2014

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Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity

Cell reports (Cambridge), 2022-08, Vol.40 (6), p.111167-111167, Article 111167

2022

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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation

Science signaling, 2021-11, Vol.14 (709), p.eabe3800

2021

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Nature (London), 2001-09, Vol.413 (6851), p.78-83

2001

Volltextzugriff (PDF)

SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter

The Journal of immunology (1950), 2014-05, Vol.192 (10), p.4821-4832

2014

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Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α

The Journal of biological chemistry, 2011-07, Vol.286 (27), p.23688-23697

2011

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TRIM-ing down Tolls

Nature immunology, 2008-04, Vol.9 (4), p.348-350

Bowie, Andrew G

2008

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Poxviral Protein A52 Stimulates p38 Mitogen-activated Protein Kinase (MAPK) Activation by Causing Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Self-association Leading to Transforming Growth Factor β-activated Kinase 1 (TAK1) Recruitment

The Journal of biological chemistry, 2013-11, Vol.288 (47), p.33642-33653

2013

Volltextzugriff (PDF)

Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection

The Journal of biological chemistry, 2006-04, Vol.281 (17), p.11637-11648

2006

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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

IFI16 is an innate immune sensor for intracellular DNA

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration

Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner

Polyinosinic Acid Is a Ligand for Toll-like Receptor 3

Vaccinia Virus Protein A52R Activates p38 Mitogen-activated Protein Kinase and Potentiates Lipopolysaccharide-induced Interleukin-10

Toll-like receptor 2–dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival

CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages

SARM1 regulates NAD+-linked metabolism and select immune genes in macrophages

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

A novel anti-viral role for STAT3 in IFN-α signalling responses

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4

Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α

TRIM-ing down Tolls

Poxviral Protein A52 Stimulates p38 Mitogen-activated Protein Kinase (MAPK) Activation by Causing Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Self-association Leading to Transforming Growth Factor β-activated Kinase 1 (TAK1) Recruitment

Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection

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