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In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors

Antimicrobial Agents and Chemotherapy, 1996-06, Vol.40 (6), p.1448-1453

1996

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Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection

Antimicrobial Agents and Chemotherapy, 2002-01, Vol.46 (1), p.55-61

2002

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Expression of cardiac cytokines and inducible form of nitric oxide synthase (NOS2) in Trypanosoma cruzi-infected mice

Journal of molecular and cellular cardiology, 1999-01, Vol.31 (1), p.75-88

1999

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Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor

Antimicrobial Agents and Chemotherapy, 1992-12, Vol.36 (12), p.2736-2740

1992

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In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides

Antimicrobial Agents and Chemotherapy, 1997-10, Vol.41 (10), p.2108-2112

1997

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Antitrypanosomal Activity of a New Triazine Derivative, SIPI 1029, In Vitro and in Model Infections

Antimicrobial Agents and Chemotherapy, 1998-10, Vol.42 (10), p.2718-2721

1998

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Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase

Antimicrobial Agents and Chemotherapy, 1990-08, Vol.34 (8), p.1485-1490

1990

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Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides

Antimicrobial Agents and Chemotherapy, 1994-03, Vol.38 (3), p.563-569

1994

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Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense

Antimicrobial Agents and Chemotherapy, 1990-06, Vol.34 (6), p.1183-1188

1990

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5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocides

Antimicrobial Agents and Chemotherapy, 1991-07, Vol.35 (7), p.1315-1320

1991

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Resistance to dl-α-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense: Role of S-adenosylmethionine

Biochemical pharmacology, 1993-08, Vol.46 (3), p.471-481

1993

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Polyamine Metabolism: A Potential Therapeutic Target in Trypanosomes

Science (American Association for the Advancement of Science), 1980-10, Vol.210 (4467), p.332-334

1980

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S-(5'-Deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): An Irreversible Inhibitor of S-Adenosylmethionine Decarboxylase with Potent in Vitro Antitrypanosomal Activity

Journal of medicinal chemistry, 1995-05, Vol.38 (10), p.1770-1777

1995

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Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives

Antimicrobial Agents and Chemotherapy, 1996-11, Vol.40 (11), p.2567-2572

1996

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Synthesis and Evaluation of Analogues of 5‘-([(Z)-4-Amino-2-butenyl]methylamino)-5‘-deoxyadenosine as Inhibitors of Tumor Cell Growth, Trypanosomal Growth, and HIV-1 Infectivity

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.5112-5122

2002

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Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (12), p.1613-1617

2001

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Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

Bioorganic & medicinal chemistry, 1997-12, Vol.5 (12), p.2145-2155

1997

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Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis

Antimicrobial Agents and Chemotherapy, 1987-09, Vol.31 (9), p.1406-1413

1987

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New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin

The American journal of tropical medicine and hygiene, 1984-11, Vol.33 (6), p.1073-1077

1984

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Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models

The American journal of tropical medicine and hygiene, 1987-01, Vol.36 (1), p.46-52

1987

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Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis

Proceedings of the National Academy of Sciences - PNAS, 1983-09, Vol.80 (18), p.5729-5733

1983

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Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections

The American journal of tropical medicine and hygiene, 1984-09, Vol.33 (5), p.845-850

1984

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Multiple Triclosan Targets in Trypanosoma brucei

Eukaryotic Cell, 2004-08, Vol.3 (4), p.855-861

2004

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Polyamines antagonize both the antileukemic activity and the reverse transcriptase stimulatory activity of 4,4′-diacetyldiphenylurea bis(guanylhydrazone) (DDUG)

Biochemical and biophysical research communications, 1987-01, Vol.142 (2), p.422-427

1987

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Trypanocidal analogs of myristate and myristoyllysophosphatidylcholine

Molecular and biochemical parasitology, 1996-10, Vol.81 (1), p.115-118

1996

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In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors

Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection

Expression of cardiac cytokines and inducible form of nitric oxide synthase (NOS2) in Trypanosoma cruzi-infected mice

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor

In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides

Antitrypanosomal Activity of a New Triazine Derivative, SIPI 1029, In Vitro and in Model Infections

Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase

Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides

Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense

5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocides

Resistance to dl-α-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense: Role of S-adenosylmethionine

Polyamine Metabolism: A Potential Therapeutic Target in Trypanosomes

S-(5'-Deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): An Irreversible Inhibitor of S-Adenosylmethionine Decarboxylase with Potent in Vitro Antitrypanosomal Activity

Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives

Synthesis and Evaluation of Analogues of 5‘-([(Z)-4-Amino-2-butenyl]methylamino)-5‘-deoxyadenosine as Inhibitors of Tumor Cell Growth, Trypanosomal Growth, and HIV-1 Infectivity

Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity

Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities

Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis

New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin

Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models

Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis

Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections

Multiple Triclosan Targets in Trypanosoma brucei

Polyamines antagonize both the antileukemic activity and the reverse transcriptase stimulatory activity of 4,4′-diacetyldiphenylurea bis(guanylhydrazone) (DDUG)

Trypanocidal analogs of myristate and myristoyllysophosphatidylcholine

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