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Extracellular vesicles: biology and emerging therapeutic opportunities

Nature reviews. Drug discovery, 2013-05, Vol.12 (5), p.347-357

2013

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Exosome-mediated delivery of siRNA in vitro and in vivo

Nature protocols, 2012-12, Vol.7 (12), p.2112-2126

2012

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Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Molecular therapy, 2017-07, Vol.25 (7), p.1580-1587

2017

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Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers

Nature Medicine, 2015-03, Vol.21 (3), p.270-275

2015

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Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Scientific reports, 2018-07, Vol.8 (1), p.10813-12, Article 10813

2018

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Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy

Molecular & cellular proteomics, 2020-12, Vol.19 (12), p.2047-2068

2020

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Use of cell-penetrating-peptides in oligonucleotide splice switching therapy

Current gene therapy, 2012-06, Vol.12 (3), p.161-178

2012

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Selective release of muscle-specific, extracellular microRNAs during myogenic differentiation

Human molecular genetics, 2016-09, Vol.25 (18), p.3960-3974

2016

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EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method

Molecular therapy. Nucleic acids, 2023-09, Vol.33, p.511-528

2023

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Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration

Human molecular genetics, 2015-12, Vol.24 (23), p.6756-6768

2015

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Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD

Molecular therapy. Nucleic acids, 2018-12, Vol.13, p.1-15

2018

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Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

The Journal of clinical investigation, 2014-09, Vol.124 (9), p.4067-4081

2014

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Preparation and Isolation of siRNA-Loaded Extracellular Vesicles

Methods in molecular biology (Clifton, N.J.), 2017-01, Vol.1545, p.197

2017

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mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration

Genomics data, 2016-03, Vol.7, p.88-89

2016

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Peptides for nucleic acid delivery

Advanced drug delivery reviews, 2016-11, Vol.106 (Pt A), p.172-182

2016

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Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

Human molecular genetics, 2012-10, Vol.21 (1), p.R125-R134

2012

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Cells release subpopulations of exosomes with distinct molecular and biological properties

Scientific reports, 2016-03, Vol.6 (1), p.22519-22519, Article 22519

2016

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Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

Scientific reports, 2017-09, Vol.7 (1), p.11561-10, Article 11561

2017

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Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles

Human gene therapy, 2015-08, Vol.26 (8), p.506-517

2015

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The viral protein corona directs viral pathogenesis and amyloid aggregation

Nature communications, 2019-05, Vol.10 (1), p.2331-16, Article 2331

2019

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A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Nature communications, 2020-02, Vol.11 (1), p.1113-1113, Article 1113

2020

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GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Nature communications, 2021-11, Vol.12 (1), p.6666-6666, Article 6666

2021

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C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia

Brain (London, England : 1878), 2017-04, Vol.140 (4), p.887-897

2017

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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Journal of extracellular vesicles, 2015-01, Vol.4 (1), p.26316-n/a

2015

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Extracellular vesicles: biology and emerging therapeutic opportunities

Exosome-mediated delivery of siRNA in vitro and in vivo

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy

Use of cell-penetrating-peptides in oligonucleotide splice switching therapy

Selective release of muscle-specific, extracellular microRNAs during myogenic differentiation

EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method

Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration

Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

Preparation and Isolation of siRNA-Loaded Extracellular Vesicles

mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration

Peptides for nucleic acid delivery

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

Cells release subpopulations of exosomes with distinct molecular and biological properties

Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles

The viral protein corona directs viral pathogenesis and amyloid aggregation

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

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