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Identification of novel plasmin inhibitors possessing nitrile moiety as warhead

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6305-6309

2011

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Relationship between structure and P-glycoprotein inhibitory activity of dimeric peptides related to the Dmt-Tic pharmacophore

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (6), p.2192-2194

2012

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Ultrasound‐induced killing of monocytic U937 cells enhanced by 2,2′‐azobis(2‐amidinopropane) dihydrochloride

Cancer science, 2004-02, Vol.95 (2), p.181-185

2004

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Application of liquid chromatography–tandem mass spectrometry for the determination of opioidmimetics in the brain dialysates from rats treated with opioidmimetics intraperitoneally

Journal of chromatography. B, 2004-06, Vol.806 (1), p.53-57

2004

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Development of Potent and Selective Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Activity Relationship

Chemical and Pharmaceutical Bulletin, 2000/12/01, Vol.48(12), pp.1964-1972

2000

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A selective plasmin inhibitor, trans-aminomethylcyclohexanecarbonyl- l-( O-picolyl)tyrosine-octylamide (YO-2), induces thymocyte apoptosis

Biochemical pharmacology, 2002-04, Vol.63 (7), p.1315-1323

2002

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An electroclinical study of absence seizures in Dravet syndrome

Epilepsy research, 2013-01, Vol.103 (1), p.88-96

2013

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Studies on the structure-activity relationship of 2', 6'-dimethyl-L-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH3

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.599-602

2005

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Isolation of Plasma Kallikrein by High Efficiency Affinity Chromatography and Its Characterization

Biological and Pharmaceutical Bulletin, 2001, Vol.24(5), pp.520-524

2001

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Identification of new agonists of urotensin-II from a cyclic peptide library

Bioorganic & medicinal chemistry, 2009-09, Vol.17 (18), p.6742-6747

2009

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Inhibitory effect of various thrombin inhibitors on shear-induced platelet function and dynamic coagulation

European journal of pharmacology, 2000-10, Vol.406 (2), p.181-189

2000

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Bifunctional [2‘,6‘-Dimethyl-l-tyrosine]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands

Journal of medicinal chemistry, 2007-06, Vol.50 (12), p.2753-2766

2007

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Development of Plasmin-Selective Inhibitors and Studies of Their Structure-Activity Relationship

Chemical and Pharmaceutical Bulletin, 2000/02/01, Vol.48(2), pp.184-193

2000

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Inhibitory Effect of Somatostatin Peptide Analogues on DNA Polymerase Activity and Human Cancer Cell Proliferation

Anticancer research, 2010-12, Vol.30 (12), p.4841-4849

2010

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Development of Potent μ-Opioid Receptor Ligands Using Unique Tyrosine Analogues of Endomorphin-2

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.586-592

2005

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Design of cyclic peptides with agonist activity at melanocortin receptor-4

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3723-3726

2006

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Development of Potent Bifunctional Endomorphin-2 Analogues with Mixed μ-/δ-Opioid Agonist and δ-Opioid Antagonist Properties

Journal of medicinal chemistry, 2004-07, Vol.47 (14), p.3591-3599

2004

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Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.2043-2046

2007

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Synthesis of Somatostatin Analogues Containing C-Terminal Adamantane and Their Antiproliferative Properties

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.5121-5124

2008

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Differentiation of opioid receptor preference by [Dmt 1]endomorphin-2-mediated antinociception in the mouse

European journal of pharmacology, 2005-02, Vol.509 (1), p.37-42

2005

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Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity

Chemical and Pharmaceutical Bulletin, 1999/08/15, Vol.47(8), pp.1193-1195

1999

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Oral Bioavailability of a New Class of μ-Opioid Receptor Agonists Containing 3,6-Bis[Dmt-NH(CH2) n ]-2(1H)-pyrazinone with Central-Mediated Analgesia

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2599-2610

2004

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Use of an active center-directed plasmin inhibitor elucidates the multiplicity of plasmin actions

Thrombosis research, 1996-04, Vol.82 (1), p.79-86

1996

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Structural studies of [2′,6′-dimethyl- l-tyrosine 1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond

Bioorganic & medicinal chemistry, 2003-05, Vol.11 (9), p.1983-1994

2003

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Unique High-Affinity Synthetic μ-Opioid Receptor Agonists with Central- and Systemic-Mediated Analgesia

Journal of medicinal chemistry, 2003-07, Vol.46 (15), p.3201-3209

2003

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Identification of novel plasmin inhibitors possessing nitrile moiety as warhead

Relationship between structure and P-glycoprotein inhibitory activity of dimeric peptides related to the Dmt-Tic pharmacophore

Ultrasound‐induced killing of monocytic U937 cells enhanced by 2,2′‐azobis(2‐amidinopropane) dihydrochloride

Application of liquid chromatography–tandem mass spectrometry for the determination of opioidmimetics in the brain dialysates from rats treated with opioidmimetics intraperitoneally

Development of Potent and Selective Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Activity Relationship

A selective plasmin inhibitor, trans-aminomethylcyclohexanecarbonyl- l-( O-picolyl)tyrosine-octylamide (YO-2), induces thymocyte apoptosis

An electroclinical study of absence seizures in Dravet syndrome

Studies on the structure-activity relationship of 2', 6'-dimethyl-L-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH3

Isolation of Plasma Kallikrein by High Efficiency Affinity Chromatography and Its Characterization

Identification of new agonists of urotensin-II from a cyclic peptide library

Inhibitory effect of various thrombin inhibitors on shear-induced platelet function and dynamic coagulation

Bifunctional [2‘,6‘-Dimethyl-l-tyrosine]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands

Development of Plasmin-Selective Inhibitors and Studies of Their Structure-Activity Relationship

Inhibitory Effect of Somatostatin Peptide Analogues on DNA Polymerase Activity and Human Cancer Cell Proliferation

Development of Potent μ-Opioid Receptor Ligands Using Unique Tyrosine Analogues of Endomorphin-2

Design of cyclic peptides with agonist activity at melanocortin receptor-4

Development of Potent Bifunctional Endomorphin-2 Analogues with Mixed μ-/δ-Opioid Agonist and δ-Opioid Antagonist Properties

Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide

Synthesis of Somatostatin Analogues Containing C-Terminal Adamantane and Their Antiproliferative Properties

Differentiation of opioid receptor preference by [Dmt 1]endomorphin-2-mediated antinociception in the mouse

Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity

Oral Bioavailability of a New Class of μ-Opioid Receptor Agonists Containing 3,6-Bis[Dmt-NH(CH2) n ]-2(1H)-pyrazinone with Central-Mediated Analgesia

Use of an active center-directed plasmin inhibitor elucidates the multiplicity of plasmin actions

Structural studies of [2′,6′-dimethyl- l-tyrosine 1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond

Unique High-Affinity Synthetic μ-Opioid Receptor Agonists with Central- and Systemic-Mediated Analgesia

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