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Schedule-Dependent Cytotoxic Synergism of Pemetrexed and Erlotinib in Human Non–Small Cell Lung Cancer Cells

Clinical cancer research, 2007-06, Vol.13 (11), p.3413-3422

2007

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Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption

Blood, 2010-12, Vol.116 (24), p.5162-5169

2010

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Prevalence of a Loss-of-Function Mutation in the Proton-Coupled Folate Transporter Gene ( PCFT-SLC46A1 ) Causing Hereditary Folate Malabsorption in Puerto Rico

The Journal of pediatrics, 2011-10, Vol.159 (4), p.623-627.e1

2011

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The Clinical Course and Genetic Defect in the PCFT Gene in a 27-Year-Old Woman with Hereditary Folate Malabsorption

The Journal of pediatrics, 2008-09, Vol.153 (3), p.435-437

2008

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Characterization of a Folate Transporter in HeLa Cells with a Low pH Optimum and High Affinity for Pemetrexed Distinct from the Reduced Folate Carrier

Clinical cancer research, 2004-09, Vol.10 (18), p.6256-6264

2004

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Antifolate Resistance in a HeLa Cell Line Associated With Impaired Transport Independent of the Reduced Folate Carrier

Clinical cancer research, 2004-12, Vol.10 (24), p.8735-8742

2004

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Loss of Reduced Folate Carrier Function and Folate Depletion Result in Enhanced Pemetrexed Inhibition of Purine Synthesis

Clinical cancer research, 2005-02, Vol.11 (3), p.1294-1301

2005

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The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitor

Cancer chemotherapy and pharmacology, 2013-09, Vol.72 (3), p.597-606

2013

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The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption

Blood, 2007-08, Vol.110 (4), p.1147-1152

2007

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The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro

Cancer chemotherapy and pharmacology, 2014-05, Vol.73 (5), p.1055-1062

2014

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Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model

Journal of neurochemistry, 2008-03, Vol.104 (6), p.1494-1503

2008

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A prominent low-pH methotrexate transport activity in human solid tumors: Contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier

Clinical cancer research, 2004-01, Vol.10 (2), p.718-727

2004

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Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: Association with the presence of a secondary transport pathway

Cancer research (Chicago, Ill.), 2004-05, Vol.64 (9), p.3313-3319

2004

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Caffeine markedly sensitizes human mesothelioma cell lines to pemetrexed

Cancer chemotherapy and pharmacology, 2008-04, Vol.61 (5), p.819-827

2008

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Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line

Biochemical pharmacology, 2003-04, Vol.65 (7), p.1163-1170

2003

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The Mechanism of Transport of the Multitargeted Antifolate (MTA) and Its Cross-resistance Pattern in Cells with Markedly Impaired Transport of Methotrexate

Clinical cancer research, 2000-09, Vol.6 (9), p.3687-3695

2000

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A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed

Cancer research (Chicago, Ill.), 2002-11, Vol.62 (22), p.6434-6437

2002

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Sensitivity to 5,10-Dideazatetrahydrofolate Is Fully Conserved in a Murine Leukemia Cell Line Highly Resistant to Methotrexate Due to Impaired Transport Mediated by the Reduced Folate Carrier

Clinical cancer research, 2000-08, Vol.6 (8), p.3304-3311

2000

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The Antifolates: New Drugs for Malignancy

Hematology/oncology clinics of North America, 2012, Vol.26 (3)

2012

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The molecular identity and characterization of a Proton-Coupled Folate Transporter- : PCFT; biological ramifications and impact on the activity of pemetrexed : Transporters in Cancer

Cancer and metastasis reviews, 2007, Vol.26 (1), p.129-139

2007

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Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells

Biochemical pharmacology, 2001-04, Vol.61 (7), p.857-865

2001

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Molecular, biochemical, and cellular pharmacology of pemetrexed: Pemetrexed (Alimta): advancing the treatment of malignant pleural mesothelioma, non-small cell lung, pancreas, and other cancers

Seminars in oncology, 2002, Vol.29 (6), p.3-17

2002

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Lack of impact of the loss of constitutive folate receptor a expression, achieved by RNA interference, on the activity of the new generation antifolate pemetrexed in HeLa cells

Clinical cancer research, 2004, Vol.10 (23), p.7986-7993

2004

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Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier

Biochemical pharmacology, 1999-11, Vol.58 (10), p.1615-1624

1999

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pH Dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells: Further evidence for a third route mediated at low pH

Biochemical pharmacology, 1997-01, Vol.53 (2), p.223-231

1997

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Schedule-Dependent Cytotoxic Synergism of Pemetrexed and Erlotinib in Human Non–Small Cell Lung Cancer Cells

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption

Prevalence of a Loss-of-Function Mutation in the Proton-Coupled Folate Transporter Gene ( PCFT-SLC46A1 ) Causing Hereditary Folate Malabsorption in Puerto Rico

The Clinical Course and Genetic Defect in the PCFT Gene in a 27-Year-Old Woman with Hereditary Folate Malabsorption

Characterization of a Folate Transporter in HeLa Cells with a Low pH Optimum and High Affinity for Pemetrexed Distinct from the Reduced Folate Carrier

Antifolate Resistance in a HeLa Cell Line Associated With Impaired Transport Independent of the Reduced Folate Carrier

Loss of Reduced Folate Carrier Function and Folate Depletion Result in Enhanced Pemetrexed Inhibition of Purine Synthesis

The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitor

The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption

The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro

Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model

A prominent low-pH methotrexate transport activity in human solid tumors: Contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier

Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: Association with the presence of a secondary transport pathway

Caffeine markedly sensitizes human mesothelioma cell lines to pemetrexed

Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line

The Mechanism of Transport of the Multitargeted Antifolate (MTA) and Its Cross-resistance Pattern in Cells with Markedly Impaired Transport of Methotrexate

A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed

Sensitivity to 5,10-Dideazatetrahydrofolate Is Fully Conserved in a Murine Leukemia Cell Line Highly Resistant to Methotrexate Due to Impaired Transport Mediated by the Reduced Folate Carrier

The Antifolates: New Drugs for Malignancy

The molecular identity and characterization of a Proton-Coupled Folate Transporter- : PCFT; biological ramifications and impact on the activity of pemetrexed : Transporters in Cancer

Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells

Molecular, biochemical, and cellular pharmacology of pemetrexed: Pemetrexed (Alimta): advancing the treatment of malignant pleural mesothelioma, non-small cell lung, pancreas, and other cancers

Lack of impact of the loss of constitutive folate receptor a expression, achieved by RNA interference, on the activity of the new generation antifolate pemetrexed in HeLa cells

Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier

pH Dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells: Further evidence for a third route mediated at low pH

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