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Hypoxic selectivity and solubility—investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (14), p.4997-5006

2010

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Synthesis, Reduction Potentials, and Antitubercular Activity of Ring A/B Analogues of the Bioreductive Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

Journal of medicinal chemistry, 2009-02, Vol.52 (3), p.637-645

2009

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Tricyclic [1,2,4]Triazine 1,4-Dioxides As Hypoxia Selective Cytotoxins

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6853-6865

2008

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Hypoxia-Activated Prodrugs: Substituent Effects on the Properties of Nitro seco-1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) Prodrugs of DNA Minor Groove Alkylating Agents

Journal of medicinal chemistry, 2009-11, Vol.52 (22), p.7258-7272

2009

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Green tea catechins partially protect DNA from ·OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals

Carcinogenesis (New York), 2001-08, Vol.22 (8), p.1189-1193

2001

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Activation of 3-Amino-1,2,4-benzotriazine 1,4-Dioxide Antitumor Agents to Oxidizing Species Following Their One-Electron Reduction

Journal of the American Chemical Society, 2003-01, Vol.125 (3), p.748-756

2003

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Hypoxia-Selective 3-Alkyl 1,2,4-Benzotriazine 1,4-Dioxides: The Influence of Hydrogen Bond Donors on Extravascular Transport and Antitumor Activity

Journal of medicinal chemistry, 2007-12, Vol.50 (26), p.6654-6664

2007

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Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

Journal of medicinal chemistry, 2003-01, Vol.46 (1), p.169-182

2003

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Potentiation of the Cytotoxicity of the Anticancer Agent Tirapazamine by Benzotriazine N-oxides: The Role of Redox Equilibria

Journal of the American Chemical Society, 2006-01, Vol.128 (1), p.245-249

2006

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Synthesis and Evaluation of Nitroheterocyclic Carbamate Prodrugs for Use with Nitroreductase-Mediated Gene-Directed Enzyme Prodrug Therapy

Journal of medicinal chemistry, 2003-12, Vol.46 (25), p.5533-5545

2003

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Hypoxia-Selective Antitumor Agents. 16. Nitroarylmethyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3511-3522

2001

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Aziridinyldinitrobenzamides: Synthesis and Structure−Activity Relationships for Activation by E. coli Nitroreductase

Journal of medicinal chemistry, 2004-06, Vol.47 (12), p.3295-3307

2004

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Pulse radiolysis studies indicate that electron transfer is involved in radioprotection by hoechst 33342 and methylproamine

International journal of radiation oncology, biology, physics, 1998-11, Vol.42 (4), p.827-831

1998

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Pathways of Reductive Fragmentation of Heterocyclic Nitroarylmethyl Quaternary Ammonium Prodrugs of Mechlorethamine

Radiation research, 2002-12, Vol.158 (6), p.753-762

2002

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Hypoxia-Selective Antitumor Agents. 14. Synthesis and Hypoxic Cell Cytotoxicity of Regioisomers of the Hypoxia-Selective Cytotoxin 5-[N,N-Bis(2-chloroethyl)amino]-2,4-dinitrobenzamide

Journal of medicinal chemistry, 1996-06, Vol.39 (13), p.2518-2528

1996

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Hypoxia-Selective Antitumor Agents. 15. Modification of Rate of Nitroreduction and Extent of Lysosomal Uptake by Polysubstitution of 4-(Alkylamino)-5-nitroquinoline Bioreductive Drugs

Journal of medicinal chemistry, 1997-04, Vol.40 (9), p.1381-1390

1997

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Oxidative metabolism of amsacrine by the neutrophil enzyme myeloperoxidase

Biochemical pharmacology, 1992-11, Vol.44 (9), p.1731-1738

1992

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Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins

Anti-cancer drug design, 1998-03, Vol.13 (2), p.81

1998

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NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation

International journal of radiation oncology, biology, physics, 1992, Vol.22 (3), p.553-556

1992

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Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis (2-chloroethyl)amino]-2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase

Anti-cancer drug design, 1996-10, Vol.11 (7), p.553

1996

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Correlation of the radiosensitization potency afforded by nitroacridine intercalators with their electron scavenging efficiency in DNA

International journal of radiation oncology, biology, physics, 1992, Vol.22 (3), p.537-540

1992

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Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

American journal of respiratory and critical care medicine, 2008-10, Vol.178 (7), p.667-672

2008

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Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women

JNCI : Journal of the National Cancer Institute, 2009-01, Vol.101 (1), p.48-60

2009

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Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial

Journal of clinical oncology, 2012-01, Vol.30 (2), p.134-141

2012

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Hypoxic selectivity and solubility—investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy

Synthesis, Reduction Potentials, and Antitubercular Activity of Ring A/B Analogues of the Bioreductive Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

Tricyclic [1,2,4]Triazine 1,4-Dioxides As Hypoxia Selective Cytotoxins

Hypoxia-Activated Prodrugs: Substituent Effects on the Properties of Nitro seco-1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) Prodrugs of DNA Minor Groove Alkylating Agents

Green tea catechins partially protect DNA from ·OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals

Activation of 3-Amino-1,2,4-benzotriazine 1,4-Dioxide Antitumor Agents to Oxidizing Species Following Their One-Electron Reduction

Hypoxia-Selective 3-Alkyl 1,2,4-Benzotriazine 1,4-Dioxides: The Influence of Hydrogen Bond Donors on Extravascular Transport and Antitumor Activity

Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

Potentiation of the Cytotoxicity of the Anticancer Agent Tirapazamine by Benzotriazine N-oxides: The Role of Redox Equilibria

Synthesis and Evaluation of Nitroheterocyclic Carbamate Prodrugs for Use with Nitroreductase-Mediated Gene-Directed Enzyme Prodrug Therapy

Hypoxia-Selective Antitumor Agents. 16. Nitroarylmethyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine

Aziridinyldinitrobenzamides: Synthesis and Structure−Activity Relationships for Activation by E. coli Nitroreductase

Pulse radiolysis studies indicate that electron transfer is involved in radioprotection by hoechst 33342 and methylproamine

Pathways of Reductive Fragmentation of Heterocyclic Nitroarylmethyl Quaternary Ammonium Prodrugs of Mechlorethamine

Hypoxia-Selective Antitumor Agents. 14. Synthesis and Hypoxic Cell Cytotoxicity of Regioisomers of the Hypoxia-Selective Cytotoxin 5-[N,N-Bis(2-chloroethyl)amino]-2,4-dinitrobenzamide

Hypoxia-Selective Antitumor Agents. 15. Modification of Rate of Nitroreduction and Extent of Lysosomal Uptake by Polysubstitution of 4-(Alkylamino)-5-nitroquinoline Bioreductive Drugs

Oxidative metabolism of amsacrine by the neutrophil enzyme myeloperoxidase

Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins

NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation

Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis (2-chloroethyl)amino]-2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase

Correlation of the radiosensitization potency afforded by nitroacridine intercalators with their electron scavenging efficiency in DNA

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women

Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial

Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study

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