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The Nuclear Receptor PXR is a Lithocholic Acid Sensor That Protects against Liver Toxicity

Proceedings of the National Academy of Sciences - PNAS, 2001-03, Vol.98 (6), p.3369-3374

2001

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Pharmacological Manipulation of Brain Kynurenine Metabolism

Annals of the New York Academy of Sciences, 2004-12, Vol.1035 (1), p.335-349

REINHARD JR, JOHN F.

2004

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Tolerability, Pharmacokinetics, and Neuroendocrine Effects of PRX-00023, a Novel 5-HT1A Agonist, in Healthy Subjects

Journal of clinical pharmacology, 2007-07, Vol.47 (7), p.817-824

2007

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Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: A 28-day, open-label study

Clinical therapeutics, 2008-09, Vol.30 (9), p.1658-1666

2008

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Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial

Journal of clinical psychopharmacology, 2008-04, Vol.28 (2), p.235-239

2008

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Interferon response heterogeneity: activation of a pro-inflammatory response by interferon alpha and beta. A possible basis for diverse responses to interferon beta in MS

Journal of leukocyte biology, 1999-04, Vol.65 (4), p.439-443

1999

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Altered tryptophan metabolism in mice with herpes simplex virus encephalitis : Increases in spinal cord quinolinic acid

Neurochemical research, 1998-05, Vol.23 (5), p.661-665

REINHARD, J. F

1998

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Role of the IBD5 susceptibility locus in the inflammatory bowel diseases

Inflammatory bowel diseases, 2006-03, Vol.12 (3), p.227-238

2006

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Human immunodeficiency virus encephalitis in SCID mice

The American journal of pathology, 1996-09, Vol.149 (3), p.1027-1053

1996

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Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: antagonism by diazepam

Naunyn-Schmiedeberg's archives of pharmacology, 1982-03, Vol.318 (4), p.374-377

1982

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The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects

Psychopharmacology, 1982-07, Vol.77 (3), p.217-222

1982

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The Neurotoxicant 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Alters Immune Function When Given in Combination with Diethyldithiocarbamate (DDC)

Annals of the New York Academy of Sciences, 1992-05, Vol.648 (1), p.309-311

1992

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Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice

Biochemical pharmacology, 1996-01, Vol.51 (2), p.159-163

1996

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Quinolinic acid and lymphocyte subsets in the intrathecal compartment as biomarkers of SIV infection and simian AIDS

AIDS research and human retroviruses, 1997-07, Vol.13 (10), p.891-897

1997

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Anticonvulsants. 5. Derivatives of 5-ethyl-5-phenylhydantoin and 5,5-diphenylhydantoin

Journal of medicinal chemistry, 1975-04, Vol.18 (4), p.383-385

1975

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The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) increases glial fibrillary acidic protein and decreases dopamine levels of the mouse striatum: Evidence for glial response to injury

Neuroscience letters, 1988-12, Vol.95 (1), p.246-251

1988

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Differences in the reserpine-sensitive storage in vivo of 1-methyl-4-phenylpyridinium in rats and mice may explain differences in catecholamine toxicity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Neurotoxicology and teratology, 1994-05, Vol.16 (3), p.277-281

1994

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Analgesics. 3. Selected 1-substituted and 1,3-disubstituted 5-propionoxy-5-(1-phenylethyl)barbituric acids

Journal of medicinal chemistry, 1975-07, Vol.18 (7), p.694-696

1975

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Potentiation by reserpine and tetrabenazine of brain catecholamine depletions by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in the mouse; evidence for subcellular sequestration as basis for cellular resistance to the toxicant

Neuroscience letters, 1988-08, Vol.90 (3), p.349-353

1988

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Anticonvulsants. 3. Phenobarbital and mephobarbital derivatives

Journal of medicinal chemistry, 1973-06, Vol.16 (6), p.602-605

1973

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Analgesics. 2. Selected 5-substituted 5-(1-phenylethyl)barbituric acids

Journal of medicinal chemistry, 1974-11, Vol.17 (11), p.1194-1197

1974

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Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase

Biochemical and biophysical research communications, 1986-06, Vol.137 (3), p.1106-1111

1986

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Analgesics. 1. Selected 5-substituted 5-propionoxybarbituric acids

Journal of medicinal chemistry, 1974-07, Vol.17 (7), p.732-736

1974

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A simple, sensitive and reliable assay for serotonin and 5-HIAA in brain tissue using liquid chromatography with electrochemical detection

Life sciences (1973), 1980-01, Vol.27 (11), p.905-911

1980

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Relation between brain 5-HIAA levels and the release of serotonin into brain synapses

Life sciences (1973), 1977-12, Vol.21 (12), p.1741-1746

1977

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The Nuclear Receptor PXR is a Lithocholic Acid Sensor That Protects against Liver Toxicity

Pharmacological Manipulation of Brain Kynurenine Metabolism

Tolerability, Pharmacokinetics, and Neuroendocrine Effects of PRX-00023, a Novel 5-HT1A Agonist, in Healthy Subjects

Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: A 28-day, open-label study

Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial

Interferon response heterogeneity: activation of a pro-inflammatory response by interferon alpha and beta. A possible basis for diverse responses to interferon beta in MS

Altered tryptophan metabolism in mice with herpes simplex virus encephalitis : Increases in spinal cord quinolinic acid

Role of the IBD5 susceptibility locus in the inflammatory bowel diseases

Human immunodeficiency virus encephalitis in SCID mice

Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: antagonism by diazepam

The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects

The Neurotoxicant 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Alters Immune Function When Given in Combination with Diethyldithiocarbamate (DDC)

Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice

Quinolinic acid and lymphocyte subsets in the intrathecal compartment as biomarkers of SIV infection and simian AIDS

Anticonvulsants. 5. Derivatives of 5-ethyl-5-phenylhydantoin and 5,5-diphenylhydantoin

The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) increases glial fibrillary acidic protein and decreases dopamine levels of the mouse striatum: Evidence for glial response to injury

Differences in the reserpine-sensitive storage in vivo of 1-methyl-4-phenylpyridinium in rats and mice may explain differences in catecholamine toxicity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Analgesics. 3. Selected 1-substituted and 1,3-disubstituted 5-propionoxy-5-(1-phenylethyl)barbituric acids

Potentiation by reserpine and tetrabenazine of brain catecholamine depletions by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in the mouse; evidence for subcellular sequestration as basis for cellular resistance to the toxicant

Anticonvulsants. 3. Phenobarbital and mephobarbital derivatives

Analgesics. 2. Selected 5-substituted 5-(1-phenylethyl)barbituric acids

Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase

Analgesics. 1. Selected 5-substituted 5-propionoxybarbituric acids

A simple, sensitive and reliable assay for serotonin and 5-HIAA in brain tissue using liquid chromatography with electrochemical detection

Relation between brain 5-HIAA levels and the release of serotonin into brain synapses

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