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Histamine-secreting microbes are increased in the gut of adult asthma patients

Journal of allergy and clinical immunology, 2016-11, Vol.138 (5), p.1491-1494.e7

2016

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Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

Nature communications, 2019-12, Vol.10 (1), p.5711-14, Article 5711

2019

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Airway host-microbiome interactions in chronic obstructive pulmonary disease

Respiratory research, 2019-06, Vol.20 (1), p.113-113, Article 113

2019

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Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

American journal of respiratory and critical care medicine, 2016-10, Vol.194 (8), p.961-973

2016

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Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model

Pharmaceutical research, 2016-11, Vol.33 (11), p.2604-2616

2016

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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Nature communications, 2018-08, Vol.9 (1), p.3174-16, Article 3174

2018

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The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

International journal of chronic obstructive pulmonary disease, 2018-01, Vol.13, p.771-780

2018

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Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat

American journal of physiology. Heart and circulatory physiology, 2006-11, Vol.291 (5), p.H2424-H2430

2006

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Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK

International journal of chronic obstructive pulmonary disease, 2017, Vol.12, p.1507-1518

2017

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Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes

Human reproduction (Oxford), 2016-08, Vol.31 (8), p.1738-1748

2016

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Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity

Blood, 2005-01, Vol.105 (2), p.489-495

2005

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Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD

Pulmonary pharmacology & therapeutics, 2017-10, Vol.46, p.69-77

2017

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Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib

The Journal of pharmacology and experimental therapeutics, 2019-06, Vol.369 (3), p.337-344

2019

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A novel cell-processing method ‘AgarCytos’ in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

Human reproduction (Oxford), 2013-10, Vol.28 (10), p.2608-2620

2013

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Use of autologous 99m Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD

Thorax, 2019-07, Vol.74 (7), p.659-666

2019

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Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor

The Journal of pharmacology and experimental therapeutics, 2019-06, Vol.369 (3), p.443-453

2019

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Lung inflammation and epithelial changes in a murine model of atopic asthma

American journal of respiratory cell and molecular biology, 1996-05, Vol.14 (5), p.425-438

1996

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An investigation of the anti‐inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells

Clinical and experimental pharmacology & physiology, 2017-09, Vol.44 (9), p.932-940

2017

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The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils

International immunopharmacology, 2016-06, Vol.35, p.155-162

2016

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Cytological evaluation of spermatogenesis: a novel and simple diagnostic method to assess spermatogenesis in non‐obstructive azoospermia using testicular sperm extraction specimens

Andrology (Oxford), 2015-05, Vol.3 (3), p.481-490

2015

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Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13780-13792

2021

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Immunostimulatory Sequences Regulate Interferon-inducible Genes but not Allergic Airway Responses

American journal of respiratory and critical care medicine, 2006-07, Vol.174 (1), p.15-20

2006

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Eosinophilic rhinitis accompanies the development of lower airway inflammation and hyper-reactivity in sensitized mice exposed to aerosolized allergen

Clinical and experimental allergy, 2001-05, Vol.31 (5), p.782-790

2001

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Involvement of IL-16 in the Induction of Airway Hyper-Responsiveness and Up-Regulation of IgE in a Murine Model of Allergic Asthma

The Journal of immunology (1950), 1998-03, Vol.160 (6), p.2998-3005

1998

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Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample

BMC biotechnology, 2014-07, Vol.14 (1), p.63-63, Article 63

2014

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Histamine-secreting microbes are increased in the gut of adult asthma patients

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

Airway host-microbiome interactions in chronic obstructive pulmonary disease

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat

Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK

Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes

Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity

Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD

Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib

A novel cell-processing method ‘AgarCytos’ in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

Use of autologous 99m Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD

Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor

Lung inflammation and epithelial changes in a murine model of atopic asthma

An investigation of the anti‐inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells

The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils

Cytological evaluation of spermatogenesis: a novel and simple diagnostic method to assess spermatogenesis in non‐obstructive azoospermia using testicular sperm extraction specimens

Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode

Immunostimulatory Sequences Regulate Interferon-inducible Genes but not Allergic Airway Responses

Eosinophilic rhinitis accompanies the development of lower airway inflammation and hyper-reactivity in sensitized mice exposed to aerosolized allergen

Involvement of IL-16 in the Induction of Airway Hyper-Responsiveness and Up-Regulation of IgE in a Murine Model of Allergic Asthma

Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample

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