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Screening for in vitro metabolites of Abelmoschus manihot extract in intestinal bacteria by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011-12, Vol.879 (32), p.3901-3908

2011

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Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity

European journal of clinical pharmacology, 2013-03, Vol.69 (3), p.507-513

2013

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CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

European journal of clinical pharmacology, 2012-05, Vol.68 (5), p.637-644

2012

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Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism

Drug metabolism and disposition, 2006-07, Vol.34 (7), p.1175-1181

2006

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Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men

British journal of clinical pharmacology, 2012-12, Vol.74 (6), p.999-1004

2012

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Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin

Drug metabolism and disposition, 2011-01, Vol.39 (1), p.92-97

2011

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Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin

European journal of clinical pharmacology, 2013-03, Vol.69 (3), p.439-448

2013

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GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin

Therapeutic drug monitoring, 2013-08, Vol.35 (4), p.473-484

2013

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CYP3A5 Genotype has an Impact on the Metabolism of the HIV Protease Inhibitor Saquinavir

Clinical pharmacology and therapeutics, 2007-05, Vol.81 (5), p.708-712

2007

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St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole

Clinical pharmacology and therapeutics, 2004-03, Vol.75 (3), p.191-197

2004

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Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation

Biochemical pharmacology, 2011-07, Vol.82 (1), p.53-64

2011

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Metabolism of methylisoeugenol in liver microsomes of human, rat, and bovine origin

Drug metabolism and disposition, 2011-09, Vol.39 (9), p.1727-1733

2011

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Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique

Journal of mass spectrometry., 2011-08, Vol.46 (8), p.725-733

2011

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Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects

European journal of clinical pharmacology, 2013-03, Vol.69 (3), p.523-532

2013

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Structural elucidation of metabolites of tanshinone I and its analogue dihydrotanshinone I in rats by HPLC―ESI-MSn

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-04, Vol.878 (13-14), p.915-924

2010

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Metabolism of TM‐2, a potential antitumor drug, in rats by using LC–MS

Journal of separation science, 2014-03, Vol.37 (6), p.625-629

2014

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The effect of psychotropic drugs on cytochrome P450 2D (CYP2D) in rat brain

European journal of pharmacology, 2011-01, Vol.651 (1-3), p.51-58

2011

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Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS

Journal of pharmaceutical and biomedical analysis, 2012-01, Vol.58 (25), p.83-93

2012

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No pharmacokinetic alteration of docetaxel following coadministration of aprepitant 3 h before docetaxel infusion

Cancer chemotherapy and pharmacology, 2014-09, Vol.74 (3), p.539-547

2014

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Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys

Drug metabolism and disposition, 2010-03, Vol.38 (3), p.459-473

2010

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Validation of a novel in vitro assay using ultra performance liquid chromatography–mass spectrometry (UPLC/MS) to detect and quantify hydroxylated metabolites of BDE-99 in rat liver microsomes

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-06, Vol.878 (19), p.1562-1568

2010

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CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population

Pharmacogenetics and genomics, 2006-09, Vol.16 (9), p.637-645

2006

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Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography–tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2012-11, Vol.70, p.624-630

2012

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Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation

European journal of clinical pharmacology, 2009-04, Vol.65 (4), p.403-409

2009

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Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1223-1231

2007

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Screening for in vitro metabolites of Abelmoschus manihot extract in intestinal bacteria by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity

CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism

Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men

Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin

Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin

GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin

CYP3A5 Genotype has an Impact on the Metabolism of the HIV Protease Inhibitor Saquinavir

St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole

Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation

Metabolism of methylisoeugenol in liver microsomes of human, rat, and bovine origin

Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique

Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects

Structural elucidation of metabolites of tanshinone I and its analogue dihydrotanshinone I in rats by HPLC―ESI-MSn

Metabolism of TM‐2, a potential antitumor drug, in rats by using LC–MS

The effect of psychotropic drugs on cytochrome P450 2D (CYP2D) in rat brain

Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC–MS/MS

No pharmacokinetic alteration of docetaxel following coadministration of aprepitant 3 h before docetaxel infusion

Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys

Validation of a novel in vitro assay using ultra performance liquid chromatography–mass spectrometry (UPLC/MS) to detect and quantify hydroxylated metabolites of BDE-99 in rat liver microsomes

CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population

Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography–tandem mass spectrometry

Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice

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