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Recent Advances in PROTAC Technology Toward New Therapeutic Modalities

Chemistry & biodiversity, 2022-11, Vol.19 (11), p.e202200828-n/a

2022

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Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (20), p.4865-4869

2016

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Development of Photoswitchable Estrogen Receptor Ligands

Chemical and Pharmaceutical Bulletin, 2020/04/01, Vol.68(4), pp.398-402

2020

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Control of STING Agonistic/Antagonistic Activity Using Amine-Skeleton-Based c-di-GMP Analogues

International journal of molecular sciences, 2022-06, Vol.23 (12), p.6847

2022

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Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs

Pharmaceuticals (Basel, Switzerland), 2020-04, Vol.13 (4), p.74

2020

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Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15868-15882

2021

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Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8772

2021

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Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles

ChemistryOpen (Weinheim), 2022-07, Vol.11 (7), p.e202200131-n/a

2022

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Protocols for Synthesis of SNIPERs and the Methods to Evaluate the Anticancer Effects

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2365, p.331

2021

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Development of Selective TGR5 Ligands Based on the 5,6,7,8‐Tetrahydro‐5,5,8,8‐tetramethylnaphthalene Skeleton

ChemMedChem, 2021-02, Vol.16 (3), p.458-462

2021

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Current Status of Oligonucleotide-Based Protein Degraders

Pharmaceutics, 2023-02, Vol.15 (3), p.765

2023

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Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase

RSC medicinal chemistry, 2022-12, Vol.13 (12), p.1495-1503

2022

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Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4478-4481

2017

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Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon

Bioorganic & medicinal chemistry, 2018-12, Vol.26 (23-24), p.6146-6152

2018

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Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5362-5366

2015

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Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (20), p.6104-6107

2011

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Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins

ACS chemical biology, 2019-12, Vol.14 (12), p.2822-2832

2019

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Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor

Bioconjugate chemistry, 2023-10, Vol.34 (10), p.1780-1788

2023

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Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands

Bioorganic & medicinal chemistry, 2023-05, Vol.86, p.117293-117293, Article 117293

2023

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Development of a peptide-based inducer of protein degradation targeting NOTCH1

Bioorganic & medicinal chemistry letters, 2017-11, Vol.27 (22), p.4985-4988

2017

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Synthesis and Anti-HIV-1 and Anti-HCMV Activity of 1-Substituted 3-(3,5-Dimethylbenzyl)uracil Derivatives

Chemical and Pharmaceutical Bulletin, 2006, Vol.54(3), pp.325-333

2006

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CRBN ligand expansion for hematopoietic prostaglandin D 2 synthase (H-PGDS) targeting PROTAC design and their in vitro ADME profiles

Bioorganic & medicinal chemistry, 2023-04, Vol.84, p.117259

2023

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Recent Advances in PROTAC Technology Toward New Therapeutic Modalities

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand

Development of Photoswitchable Estrogen Receptor Ligands

Control of STING Agonistic/Antagonistic Activity Using Amine-Skeleton-Based c-di-GMP Analogues

Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs

Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design

Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation

Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles

Protocols for Synthesis of SNIPERs and the Methods to Evaluate the Anticancer Effects

Development of Selective TGR5 Ligands Based on the 5,6,7,8‐Tetrahydro‐5,5,8,8‐tetramethylnaphthalene Skeleton

Current Status of Oligonucleotide-Based Protein Degraders

Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide

Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon

Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton

Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands

Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins

Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor

Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands

Development of a peptide-based inducer of protein degradation targeting NOTCH1

Synthesis and Anti-HIV-1 and Anti-HCMV Activity of 1-Substituted 3-(3,5-Dimethylbenzyl)uracil Derivatives

CRBN ligand expansion for hematopoietic prostaglandin D 2 synthase (H-PGDS) targeting PROTAC design and their in vitro ADME profiles

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