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A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery

Cell stem cell, 2022-07, Vol.29 (7), p.1083-1101.e7

2022

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Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

Cell, 2019-04, Vol.177 (3), p.608-621.e12

2019

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Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

The Journal of clinical investigation, 2014-06, Vol.124 (6), p.2315-2324

2014

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A polycystin-centric view of cyst formation and disease: the polycystins revisited

Kidney international, 2015-10, Vol.88 (4), p.699-710

2015

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The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex

EMBO reports, 2019-11, Vol.20 (11), p.e48336-n/a

2019

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Cardiovascular perspectives of the TRP channel polycystin 2

The Journal of physiology, 2024-04, Vol.602 (8), p.1565-1577

2024

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PKD2/polycystin-2 induces autophagy by forming a complex with BECN1

Autophagy, 2021-07, Vol.17 (7), p.1714-1728

2021

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Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner

Autophagy, 2021-09, Vol.17 (9), p.2384-2400

2021

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cell biology of polycystic kidney disease

The Journal of cell biology, 2010-11, Vol.191 (4), p.701-710

2010

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C. elegans Ciliated Sensory Neurons Release Extracellular Vesicles that Function in Animal Communication

Current biology, 2014-03, Vol.24 (5), p.519-525

2014

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The diverse effects of pathogenic point mutations on ion channel activity of a gain-of-function polycystin-2

The Journal of biological chemistry, 2023-05, Vol.299 (5), p.104674-104674, Article 104674

2023

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Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease

Journal of the American Society of Nephrology, 2022-08, Vol.33 (8), p.1501-1516

2022

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Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

EMBO reports, 2013-12, Vol.14 (12), p.1143-1148

2013

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Regulation of polycystin expression, maturation and trafficking

Cellular signalling, 2020-08, Vol.72, p.109630-109630, Article 109630

2020

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A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

The EMBO journal, 2012-03, Vol.31 (6), p.1364-1378

2012

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Polycystin Channel Complexes

Annual review of physiology, 2023-02, Vol.85 (1), p.425-448

2023

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TRP channels in health and disease at a glance

Journal of cell science, 2021-07, Vol.134 (13)

2021

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Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis

Molecular biology of the cell, 2022-12, Vol.33 (14), p.ar134-ar134

2022

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The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

Molecular biology of the cell, 2017-01, Vol.28 (2), p.261-269

2017

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Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

The Journal of clinical investigation, 2012-11, Vol.122 (11), p.4257-4273

2012

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Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

The Journal of cell biology, 2017-03, Vol.216 (3), p.743-760

2017

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High calcium transport by Polycystin-2 (TRPP2) induces channel clustering and oscillatory currents

Biochemical and biophysical research communications, 2023-06, Vol.660, p.50-57

2023

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The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus

eLife, 2020-11, Vol.9

2020

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Identification of Biomarkers for PKD1 Using Urinary Exosomes

Journal of the American Society of Nephrology, 2015-07, Vol.26 (7), p.1661-1670

2015

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Polycystic kidney disease: novel insights into polycystin function

Trends in molecular medicine, 2023-04, Vol.29 (4), p.268-281

2023

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A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

A polycystin-centric view of cyst formation and disease: the polycystins revisited

The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex

Cardiovascular perspectives of the TRP channel polycystin 2

PKD2/polycystin-2 induces autophagy by forming a complex with BECN1

Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner

cell biology of polycystic kidney disease

C. elegans Ciliated Sensory Neurons Release Extracellular Vesicles that Function in Animal Communication

The diverse effects of pathogenic point mutations on ion channel activity of a gain-of-function polycystin-2

Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

Regulation of polycystin expression, maturation and trafficking

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

Polycystin Channel Complexes

TRP channels in health and disease at a glance

Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

High calcium transport by Polycystin-2 (TRPP2) induces channel clustering and oscillatory currents

The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus

Identification of Biomarkers for PKD1 Using Urinary Exosomes

Polycystic kidney disease: novel insights into polycystin function

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