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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Blood, 2012-03, Vol.119 (13), p.3024-3030

2012

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Prolonged activity of factor IX as a monomeric Fc fusion protein

Blood, 2010-03, Vol.115 (10), p.2057-2064

2010

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Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4‐driven transcriptional state

Molecular oncology, 2022-03, Vol.16 (6), p.1309-1328

2022

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Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

Blood, 2010-12, Vol.116 (26), p.5842-5848

2010

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Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release

International journal of molecular sciences, 2022-10, Vol.23 (19), p.11635

2022

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Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors

Molecular therapy, 2011-03, Vol.19 (3), p.442-449

2011

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Adeno-associated virus-mediated expression of activated factor V (FVa) for hemophilia phenotypic correction

Frontiers in medicine, 2022-08, Vol.9, p.880763-880763

2022

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Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog

Frontiers in pharmacology, 2022-01, Vol.13, p.815317-815317

2022

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AAV gene therapy in companion dogs with severe hemophilia: Real-world long-term data on immunogenicity, efficacy, and quality of life

Molecular therapy. Methods & clinical development, 2024-03, Vol.32 (1), p.101205-101205, Article 101205

2024

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Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B

Blood, 2010-06, Vol.115 (23), p.4678-4688

2010

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Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

Journal of translational medicine, 2017-05, Vol.15 (1), p.94-94, Article 94

2017

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A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells

Nature biotechnology, 2021-01, Vol.39 (1), p.47-55

2021

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Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

Molecular therapy. Methods & clinical development, 2020-09, Vol.18, p.259-268

2020

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Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog

Molecular therapy. Methods & clinical development, 2023-12, Vol.31, p.101159-101159, Article 101159

2023

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Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

Blood, 2005-04, Vol.105 (8), p.3079-3086

2005

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Cardiovascular disease, inflammation, and periodontal infection

Periodontology 2000, 2007-06, Vol.44 (1), p.113-126

2007

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Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Blood, 2009-04, Vol.113 (16), p.3682-3689

2009

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Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs

Molecular therapy, 2010-07, Vol.18 (7), p.1318-1329

2010

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Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Blood, 2009-11, Vol.114 (20), p.4562-4565

2009

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Bad cholesterol breaking really bad

Blood, 2013-11, Vol.122 (22), p.3551-3553

Nichols, Timothy C.

2013

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Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

Nature medicine, 1999-01, Vol.5 (1), p.56-63

1999

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Dexamethasone Transiently Enhances Transgene Expression in the Liver When Administered at Late-Phase Post Long-Term Adeno-Associated Virus Transduction

Human gene therapy, 2022-02, Vol.33 (3-4), p.119

2022

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Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis

Arteriosclerosis, thrombosis, and vascular biology, 2019-11, Vol.39 (11), p.2261

2019

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Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce

Molecular therapy, 2017-02, Vol.25 (2), p.512-522

2017

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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Prolonged activity of factor IX as a monomeric Fc fusion protein

Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4‐driven transcriptional state

Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide

Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release

Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors

Adeno-associated virus-mediated expression of activated factor V (FVa) for hemophilia phenotypic correction

Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog

AAV gene therapy in companion dogs with severe hemophilia: Real-world long-term data on immunogenicity, efficacy, and quality of life

Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog

Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

Cardiovascular disease, inflammation, and periodontal infection

Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs

Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Bad cholesterol breaking really bad

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

Dexamethasone Transiently Enhances Transgene Expression in the Liver When Administered at Late-Phase Post Long-Term Adeno-Associated Virus Transduction

Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis

Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce

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