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Identification of RIP1 kinase as a specific cellular target of necrostatins

Nature chemical biology, 2008-05, Vol.4 (5), p.313-321

2008

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A novel screening method to assess developability of antibody-like molecules

mAbs, 2015-07, Vol.7 (4), p.752-758

2015

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Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Bioorganic & medicinal chemistry, 2013-07, Vol.21 (14), p.4011-4019

2013

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Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies

Methods (San Diego, Calif.), 2014-01, Vol.65 (1), p.95-104

2014

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MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors

Molecular cancer therapeutics, 2014-02, Vol.13 (2), p.410-425

2014

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Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer

Clinical cancer research, 2018-06, Vol.24 (12), p.2873-2885

2018

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Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics

mAbs, 2022, Vol.14 (1), p.2083466-2083466

2022

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Identification and Characterization of Mefloquine Efficacy against JC Virus In Vitro

Antimicrobial Agents and Chemotherapy, 2009-05, Vol.53 (5), p.1840-1849

2009

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Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E

Cell, 2003-12, Vol.115 (6), p.739-750

2003

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Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML)

PLoS genetics, 2009-02, Vol.5 (2), p.e1000368-e1000368

2009

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Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36

The Journal of biological chemistry, 2007-01, Vol.282 (4), p.2450-2455

2007

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De novo discovery of antibody drugs - great promise demands scrutiny

mAbs, 2019-07, Vol.11 (5), p.809-811

2019

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Rational engineering of antibody therapeutics targeting multiple oncogene pathways

mAbs, 2011-05, Vol.3 (3), p.299-309

2011

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Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

Protein science, 2010-05, Vol.19 (5), p.954-966

2010

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Rapid optimization and prototyping for therapeutic antibody-like molecules

mAbs, 2013-03, Vol.5 (2), p.237-254

2013

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The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor

Cell, 2003-07, Vol.114 (1), p.99-111

2003

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Stability engineering of scFvs for the development of bispecific and multivalent antibodies

Protein engineering, design and selection, 2010-07, Vol.23 (7), p.549-557

2010

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Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

Structure (London), 2008-05, Vol.16 (5), p.798-808

2008

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Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle

mAbs, 2015-01, Vol.7 (1), p.42-52

2015

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Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR

mAbs, 2009-03, Vol.1 (2), p.128-141

2009

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Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting

mAbs, 2017-01, Vol.9 (1), p.58-67

2017

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Conserved amino acid networks involved in antibody variable domain interactions

Proteins, structure, function, and bioinformatics, 2009-07, Vol.76 (1), p.99-114

2009

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Affinity enhancement of an in vivo matured therapeutic antibody using structure‐based computational design

Protein science, 2006-05, Vol.15 (5), p.949-960

2006

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9th annual European Antibody Congress, November 11-13, 2013, Geneva, Switzerland

mAbs, 2014-03, Vol.6 (2), p.309-326

2014

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Design of next-generation protein therapeutics

Current opinion in chemical biology, 2010-08, Vol.14 (4), p.520-528

2010

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Identification of RIP1 kinase as a specific cellular target of necrostatins

A novel screening method to assess developability of antibody-like molecules

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies

MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors

Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer

Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics

Identification and Characterization of Mefloquine Efficacy against JC Virus In Vitro

Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E

Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML)

Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36

De novo discovery of antibody drugs - great promise demands scrutiny

Rational engineering of antibody therapeutics targeting multiple oncogene pathways

Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

Rapid optimization and prototyping for therapeutic antibody-like molecules

The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor

Stability engineering of scFvs for the development of bispecific and multivalent antibodies

Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR

Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting

Conserved amino acid networks involved in antibody variable domain interactions

Affinity enhancement of an in vivo matured therapeutic antibody using structure‐based computational design

9th annual European Antibody Congress, November 11-13, 2013, Geneva, Switzerland

Design of next-generation protein therapeutics

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