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Crystal Structure of Carbapenemase OXA-58 from Acinetobacter baumannii

Antimicrobial agents and chemotherapy, 2014-04, Vol.58 (4), p.2135-2143

2014

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The Class A β-Lactamase FTU-1 Is Native to Francisella tularensis

Antimicrobial Agents and Chemotherapy, 2012-02, Vol.56 (2), p.666-671

2012

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Novel Aminoglycoside 2″-Phosphotransferase Identified in a Gram-Negative Pathogen

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.452-457

2013

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Antibiotic Resistance and Substrate Profiles of the Class A Carbapenemase KPC-6

Antimicrobial Agents and Chemotherapy, 2012-11, Vol.56 (11), p.6006-6008

2012

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Co-opting the Cell Wall in Fighting Methicillin-Resistant Staphylococcus aureus: Potent Inhibition of PBP 2a by Two Anti-MRSA β-Lactam Antibiotics

Journal of the American Chemical Society, 2008-07, Vol.130 (29), p.9212-9213

2008

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Mutant APH(2″)-IIa Enzymes with Increased Activity against Amikacin and Isepamicin

Antimicrobial Agents and Chemotherapy, 2010-04, Vol.54 (4), p.1590-1595

2010

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Revisiting the Nucleotide and Aminoglycoside Substrate Specificity of the Bifunctional Aminoglycoside Acetyltransferase(6′)-Ie/Aminoglycoside Phosphotransferase(2″)-Ia Enzyme

The Journal of biological chemistry, 2012-12, Vol.287 (52), p.43262-43269

2012

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A surface loop modulates activity of the Bacillus class D β-lactamases

Journal of structural biology, 2020-08, Vol.211 (2), p.107544-107544, Article 107544

2020

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Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type β‑Lactamases

Biochemistry (Easton), 2015-01, Vol.54 (2), p.588-597

2015

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Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective against Methicillin- and Vancomycin-resistant Staphylococcus aureus

The Journal of biological chemistry, 2006-04, Vol.281 (15), p.10035-10041

2006

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The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus

The Journal of biological chemistry, 2004-09, Vol.279 (39), p.40802-40806

2004

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Mechanistic Basis for the Emergence of Catalytic Competence against Carbapenem Antibiotics by the GES Family of β-Lactamases

The Journal of biological chemistry, 2009-10, Vol.284 (43), p.29509-29513

2009

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The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases

ACS infectious diseases, 2023-05, Vol.9 (5), p.1123-1136

2023

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Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES‑5 Carbapenemase

ACS infectious diseases, 2024-04, Vol.10 (4), p.1232-1249

2024

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Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia

Acta crystallographica. Section D, Biological crystallography., 2014-06, Vol.70 (6), p.1561-1571

2014

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Inhibition of the Clostridioides difficile Class D β‑Lactamase CDD‑1 by Avibactam

ACS infectious diseases, 2021-05, Vol.7 (5), p.1164-1176

2021

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Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime

Antimicrobial Agents and Chemotherapy, 2002-06, Vol.46 (6), p.1966-1970

2002

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Resistance to the Third-Generation Cephalosporin Ceftazidime by a Deacylation-Deficient Mutant of the TEM β-Lactamase by the Uncommon Covalent-Trapping Mechanism

Biochemistry (Easton), 2011-07, Vol.50 (29), p.6387-6395

2011

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Identification of Products of Inhibition of GES-2 β-Lactamase by Tazobactam by X-ray Crystallography and Spectrometry

The Journal of biological chemistry, 2011-04, Vol.286 (16), p.14396-14409

2011

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Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

Chemistry & biology, 2013-09, Vol.20 (9), p.1107-1115

2013

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Structural Consequences of the Inhibitor-Resistant Ser130Gly Substitution in TEM β-Lactamase

Biochemistry (Easton), 2005-07, Vol.44 (26), p.9330-9338

2005

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Design of Novel Antibiotics that Bind to the Ribosomal Acyltransfer Site

Journal of the American Chemical Society, 2002-04, Vol.124 (13), p.3229-3237

2002

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Characterization of the β-Lactam Antibiotic Sensor Domain of the MecR1 Signal Sensor/Transducer Protein from Methicillin-Resistant Staphylococcus aureus

Biochemistry (Easton), 2007-07, Vol.46 (26), p.7822-7831

2007

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Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus

The Journal of biological chemistry, 2003-05, Vol.278 (20), p.18419-18425

2003

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The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins

The Journal of biological chemistry, 2004-08, Vol.279 (33), p.34665-34673

2004

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Crystal Structure of Carbapenemase OXA-58 from Acinetobacter baumannii

The Class A β-Lactamase FTU-1 Is Native to Francisella tularensis

Novel Aminoglycoside 2″-Phosphotransferase Identified in a Gram-Negative Pathogen

Antibiotic Resistance and Substrate Profiles of the Class A Carbapenemase KPC-6

Co-opting the Cell Wall in Fighting Methicillin-Resistant Staphylococcus aureus: Potent Inhibition of PBP 2a by Two Anti-MRSA β-Lactam Antibiotics

Mutant APH(2″)-IIa Enzymes with Increased Activity against Amikacin and Isepamicin

Revisiting the Nucleotide and Aminoglycoside Substrate Specificity of the Bifunctional Aminoglycoside Acetyltransferase(6′)-Ie/Aminoglycoside Phosphotransferase(2″)-Ia Enzyme

A surface loop modulates activity of the Bacillus class D β-lactamases

Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type β‑Lactamases

Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective against Methicillin- and Vancomycin-resistant Staphylococcus aureus

The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus

Mechanistic Basis for the Emergence of Catalytic Competence against Carbapenem Antibiotics by the GES Family of β-Lactamases

The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases

Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES‑5 Carbapenemase

Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia

Inhibition of the Clostridioides difficile Class D β‑Lactamase CDD‑1 by Avibactam

Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime

Resistance to the Third-Generation Cephalosporin Ceftazidime by a Deacylation-Deficient Mutant of the TEM β-Lactamase by the Uncommon Covalent-Trapping Mechanism

Identification of Products of Inhibition of GES-2 β-Lactamase by Tazobactam by X-ray Crystallography and Spectrometry

Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

Structural Consequences of the Inhibitor-Resistant Ser130Gly Substitution in TEM β-Lactamase

Design of Novel Antibiotics that Bind to the Ribosomal Acyltransfer Site

Characterization of the β-Lactam Antibiotic Sensor Domain of the MecR1 Signal Sensor/Transducer Protein from Methicillin-Resistant Staphylococcus aureus

Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus

The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins

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