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Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain

PloS one, 2014-09, Vol.9 (9), p.e108693-e108693

2014

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Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle

PloS one, 2011-05, Vol.6 (5), p.e19878-e19878

2011

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A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

Diabetes (New York, N.Y.), 2012-05, Vol.61 (5), p.1263-1271

2012

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XOMA 052, an anti‐IL‐1β monoclonal antibody, prevents IL‐1β‐mediated insulin resistance in 3T3‐L1 adipocytes

Obesity (Silver Spring, Md.), 2013-02, Vol.21 (2), p.306-309

2013

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Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1407-1410

2004

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Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia

American journal of physiology: endocrinology and metabolism, 2006-04, Vol.290 (4), p.E746-E749

2006

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Role of PC-1 in The Etiology of Insulin Resistance

Annals of the New York Academy of Sciences, 1999-11, Vol.892 (1), p.204-222

1999

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Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification

Biochemistry (Easton), 1993-12, Vol.32 (49), p.13531-13536

1993

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Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patient with insulin resistance and NIDDM

Diabetes (New York, N.Y.), 1991-02, Vol.40 (2), p.295-299

1991

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Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation

The Journal of biological chemistry, 1991-04, Vol.266 (11), p.6731-6736

1991

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Monoclonal Antibodies to the Human Insulin Receptor that Activate Glucose Transport but not Insulin Receptor Kinase Activity

Proceedings of the National Academy of Sciences - PNAS, 1987-05, Vol.84 (10), p.3448-3451

1987

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High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells

The Journal of clinical investigation, 1992-03, Vol.89 (3), p.899-908

1992

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Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor α-subunit

Biochemical and biophysical research communications, 1988-11, Vol.157 (1), p.321-329

1988

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Monoclonal Antibodies to the Human Insulin Receptor Block Insulin Binding and Inhibit Insulin Action

Proceedings of the National Academy of Sciences - PNAS, 1982-12, Vol.79 (23), p.7312-7316

1982

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Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels

Diabetes (New York, N.Y.), 1989-02, Vol.38 (2), p.182-187

1989

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Production of antibodies that inhibit the binding of insulin to its receptor

Biochemical and biophysical research communications, 1981-08, Vol.101 (3), p.979-987

1981

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Insulin-cholera toxin binding unit conjugate: A hybrid molecule with insulin biological activity and cholera toxin binding specificity

Journal of cellular physiology, 1983-05, Vol.115 (2), p.151-158

1983

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Interactions of a monoclonal antibody to the insulin receptor with receptors for insulin-like growth factors

Endocrinology (Philadelphia), 1983-05, Vol.112 (5), p.1865-1867

1983

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Chloroquine stimulation of insulin binding to IM-9 lymphocytes: Evidence for action at a nonlysosomal site

Biochemical and biophysical research communications, 1981-12, Vol.103 (3), p.863-871

1981

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The effect of phenformin and other adenosine triphosphate (ATP)-lowering agents on insulin binding to IM-9 human cultured lymphocytes

Journal of cellular biochemistry, 1984, Vol.24 (2), p.177-186

1984

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Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain

Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

XOMA 052, an anti‐IL‐1β monoclonal antibody, prevents IL‐1β‐mediated insulin resistance in 3T3‐L1 adipocytes

Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia

Role of PC-1 in The Etiology of Insulin Resistance

Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification

Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patient with insulin resistance and NIDDM

Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation

Monoclonal Antibodies to the Human Insulin Receptor that Activate Glucose Transport but not Insulin Receptor Kinase Activity

High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells

Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor α-subunit

Monoclonal Antibodies to the Human Insulin Receptor Block Insulin Binding and Inhibit Insulin Action

Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels

Production of antibodies that inhibit the binding of insulin to its receptor

Insulin-cholera toxin binding unit conjugate: A hybrid molecule with insulin biological activity and cholera toxin binding specificity

Interactions of a monoclonal antibody to the insulin receptor with receptors for insulin-like growth factors

Chloroquine stimulation of insulin binding to IM-9 lymphocytes: Evidence for action at a nonlysosomal site

The effect of phenformin and other adenosine triphosphate (ATP)-lowering agents on insulin binding to IM-9 human cultured lymphocytes

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