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Molecular mechanisms of antibody somatic hypermutation

Annual review of biochemistry, 2007-01, Vol.76 (1), p.1-22

2007

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DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

eLife, 2013-04, Vol.2, p.e00534

2013

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Antibody diversification by somatic mutation: from Burnet onwards

Immunology and cell biology, 2008-02, Vol.86 (2), p.124-132

Neuberger, Michael S

2008

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Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

The Journal of experimental medicine, 2010-01, Vol.207 (1), p.141-153

2010

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Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases

Molecular biology and evolution, 2005-02, Vol.22 (2), p.367-377

2005

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DNA Deamination Mediates Innate Immunity to Retroviral Infection

Cell, 2003-06, Vol.113 (6), p.803-809

2003

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stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (16), p.6736-6741

2009

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The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G

Current biology, 2003-11, Vol.13 (22), p.2009-2013

2003

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Interaction between Antibody-Diversification Enzyme AID and Spliceosome-Associated Factor CTNNBL1

Molecular cell, 2008-08, Vol.31 (4), p.474-484

2008

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AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

Nature structural & molecular biology, 2009-07, Vol.16 (7), p.769-776

2009

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The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification

The FASEB journal, 2011-04, Vol.25 (4), p.1123-1132

2011

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DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives

AID for Immunoglobulin Diversity, 2007, Vol.94, p.37-73

2007

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Human APOBEC3G Can Restrict Retroviral Infection in Avian Cells and Acts Independently of both UNG and SMUG1

Journal of Virology, 2008-05, Vol.82 (9), p.4660-4664

2008

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Mice Deficient in APOBEC2 and APOBEC3

Molecular and Cellular Biology, 2005-08, Vol.25 (16), p.7270-7277

2005

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TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

Immunity (Cambridge, Mass.), 1998-12, Vol.9 (6), p.859-869

1998

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Mutational Processes Molding the Genomes of 21 Breast Cancers

Cell, 2012-05, Vol.149 (5), p.979-993

2012

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REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase

The Journal of experimental medicine, 2011-11, Vol.208 (12), p.2385-2391

2011

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Nature (London), 2002-07, Vol.418 (6893), p.99-104

2002

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B cells acquire antigen from target cells after synapse formation

Nature (London), 2001-05, Vol.411 (6836), p.489-494

2001

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Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T

The Journal of experimental medicine, 2007-01, Vol.204 (1), p.7-10

2007

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High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region

The Journal of immunology (1950), 2013-02, Vol.190 (4), p.1481-1490

2013

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Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

Nature biotechnology, 2002-11, Vol.20 (11), p.1129-1134

2002

Volltextzugriff (PDF)

Comparison of the Differential Context-dependence of DNA Deamination by APOBEC Enzymes: Correlation with Mutation Spectra in Vivo

Journal of molecular biology, 2004-03, Vol.337 (3), p.585-596

2004

Volltextzugriff (PDF)

Immunity through DNA deamination

Trends in biochemical sciences (Amsterdam. Regular ed.), 2003-06, Vol.28 (6), p.305-312

2003

Volltextzugriff (PDF)

Pillars article: AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 2002. 418: 99-103

The Journal of immunology (1950), 2015-03, Vol.194 (5), p.2043-2047

2015

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Molecular mechanisms of antibody somatic hypermutation

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Antibody diversification by somatic mutation: from Burnet onwards

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases

DNA Deamination Mediates Innate Immunity to Retroviral Infection

stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G

Interaction between Antibody-Diversification Enzyme AID and Spliceosome-Associated Factor CTNNBL1

AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification

DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives

Human APOBEC3G Can Restrict Retroviral Infection in Avian Cells and Acts Independently of both UNG and SMUG1

Mice Deficient in APOBEC2 and APOBEC3

TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

Mutational Processes Molding the Genomes of 21 Breast Cancers

REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

B cells acquire antigen from target cells after synapse formation

Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T

High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

Comparison of the Differential Context-dependence of DNA Deamination by APOBEC Enzymes: Correlation with Mutation Spectra in Vivo

Immunity through DNA deamination

Pillars article: AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 2002. 418: 99-103

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