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Structural mechanism of ligand activation in human calcium-sensing receptor

eLife, 2016-07, Vol.5 (2016)

2016

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Crystal structure of ultra-humanized anti-pTau Fab reveals how germline substitutions humanize CDRs without loss of binding

Scientific reports, 2022-05, Vol.12 (1), p.8699-8699, Article 8699

2022

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Structural mechanism of ligand activation in human GABA(B) receptor

Nature (London), 2013-12, Vol.504 (7479), p.254-259

2013

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Symmetric activation and modulation of the human calcium-sensing receptor

Proceedings of the National Academy of Sciences - PNAS, 2021-12, Vol.118 (51)

2021

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Tyrosine Sulfation at Antibody Light Chain CDR-1 Increases Binding Affinity and Neutralization Potency to Interleukine-4

International journal of molecular sciences, 2024-02, Vol.25 (3), p.1931

2024

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Axitinib inhibits retinal and choroidal neovascularization in in vitro and in vivo models

Experimental eye research, 2016-04, Vol.145, p.373-379

2016

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Crystal Structure of a Human IκB Kinase β Asymmetric Dimer

The Journal of biological chemistry, 2013-08, Vol.288 (31), p.22758-22767

2013

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Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics

The Journal of biological chemistry, 2013-06, Vol.288 (23), p.16529-16537

2013

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An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

The Journal of biological chemistry, 2012-12, Vol.287 (53), p.44425-44434

2012

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Protein science, 2008-01, Vol.17 (1), p.16-21

2008

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Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis

The Journal of biological chemistry, 2013-06, Vol.288 (24), p.17408-17419

2013

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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

Nature (London), 2001-03, Vol.410 (6828), p.608-611

2001

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Catalytic Domain Crystal Structure of Protein Kinase C-θ (PKCθ)

The Journal of biological chemistry, 2004-11, Vol.279 (48), p.50401-50409

2004

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Two N-Terminal Domains of Kv4 K + Channels Regulate Binding to and Modulation by KChIP1

Neuron (Cambridge, Mass.), 2004-02, Vol.41 (4), p.587-598

2004

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An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity

Cancer immunology research, 2021-10, Vol.9 (10), p.1141-1157

2021

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Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2

Nature neuroscience, 2012-06, Vol.15 (7), p.970-978

2012

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Structural basis for auxiliary subunit KCTD16 regulation of the GABA B receptor

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (17), p.8370-8379

2019

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Three-Dimensional Structure and Biophysical Characterization of Staphylococcus aureus Cell Surface Antigen–Manganese Transporter MntC

Journal of molecular biology, 2013-09, Vol.425 (18), p.3429-3445

2013

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Synthesis and Activity of Substituted 4-(Indazol-3-yl)phenols as Pathway-Selective Estrogen Receptor Ligands Useful in the Treatment of Rheumatoid Arthritis

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6435-6438

2004

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Triad of polar residues implicated in pH specificity of acidic mammalian chitinase

Protein science, 2009-03, Vol.18 (3), p.569-578

2009

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Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)‑B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor‑β

Biochemistry (Easton), 2015-03, Vol.54 (10), p.1918-1929

2015

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A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1267-1276

2016

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The Structure of the Lingo-1 Ectodomain, a Module Implicated in Central Nervous System Repair Inhibition

The Journal of biological chemistry, 2006-11, Vol.281 (47), p.36378-36390

2006

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Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: Molecular insights and effector modulation of N-acetylglucosaminyltransferase I

Biotechnology and bioengineering, 2012-07, Vol.109 (7), p.1723-1734

2012

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Swift residue-screening identifies key N-glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo-1

FEBS letters, 2009-03, Vol.583 (6), p.1034-1038

2009

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Structural mechanism of ligand activation in human calcium-sensing receptor

Crystal structure of ultra-humanized anti-pTau Fab reveals how germline substitutions humanize CDRs without loss of binding

Structural mechanism of ligand activation in human GABA(B) receptor

Symmetric activation and modulation of the human calcium-sensing receptor

Tyrosine Sulfation at Antibody Light Chain CDR-1 Increases Binding Affinity and Neutralization Potency to Interleukine-4

Axitinib inhibits retinal and choroidal neovascularization in in vitro and in vivo models

Crystal Structure of a Human IκB Kinase β Asymmetric Dimer

Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics

An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

Catalytic Domain Crystal Structure of Protein Kinase C-θ (PKCθ)

Two N-Terminal Domains of Kv4 K + Channels Regulate Binding to and Modulation by KChIP1

An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity

Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2

Structural basis for auxiliary subunit KCTD16 regulation of the GABA B receptor

Three-Dimensional Structure and Biophysical Characterization of Staphylococcus aureus Cell Surface Antigen–Manganese Transporter MntC

Synthesis and Activity of Substituted 4-(Indazol-3-yl)phenols as Pathway-Selective Estrogen Receptor Ligands Useful in the Treatment of Rheumatoid Arthritis

Triad of polar residues implicated in pH specificity of acidic mammalian chitinase

Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)‑B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor‑β

A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

The Structure of the Lingo-1 Ectodomain, a Module Implicated in Central Nervous System Repair Inhibition

Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: Molecular insights and effector modulation of N-acetylglucosaminyltransferase I

Swift residue-screening identifies key N-glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo-1

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