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Molecular Structure and Function of the Glycine Receptor Chloride Channel

Physiological reviews, 2004-10, Vol.84 (4), p.1051-1095

Lynch, Joseph W

2004

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The impact of human hyperekplexia mutations on glycine receptor structure and function

Molecular brain, 2014-01, Vol.7 (1), p.2-2

2014

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Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels

British journal of pharmacology, 2012-04, Vol.165 (8), p.2707-2720

2012

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Investigating ion channel conformational changes using voltage clamp fluorometry

Neuropharmacology, 2015-11, Vol.98, p.3-12

2015

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An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations

The Journal of biological chemistry, 2010-05, Vol.285 (20), p.14890-14897

2010

Volltextzugriff (PDF)

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

PLoS pathogens, 2017-10, Vol.13 (10), p.e1006663-e1006663

2017

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An outline of desensitization in pentameric ligand-gated ion channel receptors

Cellular and molecular life sciences : CMLS, 2013-04, Vol.70 (7), p.1241-1253

2013

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Correlating Structural and Energetic Changes in Glycine Receptor Activation

The Journal of biological chemistry, 2015-02, Vol.290 (9), p.5621-5634

2015

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Native glycine receptor subtypes and their physiological roles

Neuropharmacology, 2009-01, Vol.56 (1), p.303-309

Lynch, Joseph W.

2009

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Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia

The Journal of biological chemistry, 2016-07, Vol.291 (29), p.15332-15341

2016

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The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine

Structure (London), 2014-10, Vol.22 (10), p.1399-1407

2014

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Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations

Neuropharmacology, 2015-02, Vol.89, p.391-397

2015

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Molecular pharmacology of the glycine receptor chloride channel

Current pharmaceutical design, 2007-08, Vol.13 (23), p.2350

2007

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Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells

PloS one, 2013-03, Vol.8 (3), p.e58479-e58479

2013

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Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

The Journal of neuroscience, 2017-08, Vol.37 (33), p.7948-7961

2017

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Phosphorylation of α3 Glycine Receptors Induces a Conformational Change in the Glycine-Binding Site

ACS chemical neuroscience, 2013-10, Vol.4 (10), p.1361-1370

2013

Volltextzugriff (PDF)

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia

Organic & biomolecular chemistry, 2013-07, Vol.11 (28), p.4695-4701

2013

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Novel missense mutations in the glycine receptor β subunit gene ( GLRB ) in startle disease

Neurobiology of disease, 2013-04, Vol.52, p.137-149

2013

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Ivermectin binding sites in human and invertebrate Cys-loop receptors

Trends in pharmacological sciences (Regular ed.), 2012-08, Vol.33 (8), p.432-441

2012

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Conformational Variability of the Glycine Receptor M2 Domain in Response to Activation by Different Agonists

The Journal of biological chemistry, 2007-12, Vol.282 (49), p.36057-36067

2007

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β Subunit M2-M3 loop conformational changes are uncoupled from α1 β glycine receptor channel gating: implications for human hereditary hyperekplexia

PloS one, 2011-11, Vol.6 (11), p.e28105-e28105

2011

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GLRB is the third major gene of effect in hyperekplexia

Human molecular genetics, 2013-03, Vol.22 (5), p.927-940

2013

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Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine

Biochemical pharmacology, 2008-10, Vol.76 (8), p.1014-1023

2008

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GABAA Receptor α and γ Subunits Shape Synaptic Currents via Different Mechanisms

The Journal of biological chemistry, 2014-02, Vol.289 (9), p.5399-5411

2014

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Ircinialactams: Subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

Bioorganic & medicinal chemistry, 2010-04, Vol.18 (8), p.2912-2919

2010

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Molecular Structure and Function of the Glycine Receptor Chloride Channel

The impact of human hyperekplexia mutations on glycine receptor structure and function

Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels

Investigating ion channel conformational changes using voltage clamp fluorometry

An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

An outline of desensitization in pentameric ligand-gated ion channel receptors

Correlating Structural and Energetic Changes in Glycine Receptor Activation

Native glycine receptor subtypes and their physiological roles

Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia

The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations

Molecular pharmacology of the glycine receptor chloride channel

Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells

Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

Phosphorylation of α3 Glycine Receptors Induces a Conformational Change in the Glycine-Binding Site

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia

Novel missense mutations in the glycine receptor β subunit gene ( GLRB ) in startle disease

Ivermectin binding sites in human and invertebrate Cys-loop receptors

Conformational Variability of the Glycine Receptor M2 Domain in Response to Activation by Different Agonists

β Subunit M2-M3 loop conformational changes are uncoupled from α1 β glycine receptor channel gating: implications for human hereditary hyperekplexia

GLRB is the third major gene of effect in hyperekplexia

Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine

GABAA Receptor α and γ Subunits Shape Synaptic Currents via Different Mechanisms

Ircinialactams: Subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

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