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Regional intestinal drug permeation: Biopharmaceutics and drug development

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.333-341

Lennernas, Hans

2014

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Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

Biomedicine & pharmacotherapy, 2023-06, Vol.162, p.114644-114644, Article 114644

2023

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Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

Molecular pharmaceutics, 2014-01, Vol.11 (1), p.12-23

Lennernäs, Hans

2014

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Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Molecules (Basel, Switzerland), 2020-06, Vol.25 (12), p.2861

2020

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Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Molecular pharmaceutics, 2015-06, Vol.12 (6), p.2026-2039

2015

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Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

International journal of molecular sciences, 2021-12, Vol.22 (23), p.13051

2021

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In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

European journal of pharmaceutical sciences, 2013-07, Vol.49 (4), p.679-698

2013

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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Scientific reports, 2023-01, Vol.13 (1), p.748-748, Article 748

2023

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The Fraction Dose Absorbed, in Humans, and High Jejunal Human Permeability Relationship

Molecular pharmaceutics, 2012-06, Vol.9 (6), p.1847-1851

2012

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Direct In Vivo Human Intestinal Permeability (Peff) Determined with Different Clinical Perfusion and Intubation Methods

Journal of pharmaceutical sciences, 2015-09, Vol.104 (9), p.2702-2726

2015

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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Cells (Basel, Switzerland), 2022-02, Vol.11 (4), p.632

2022

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Toward an Increased Understanding of the Barriers to Colonic Drug Absorption in Humans: Implications for Early Controlled Release Candidate Assessment

Molecular pharmaceutics, 2009-02, Vol.6 (1), p.60-73

2009

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Regional Intestinal Permeability of Three Model Drugs in Human

Molecular pharmaceutics, 2016-09, Vol.13 (9), p.3013-3021

2016

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Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Molecular pharmaceutics, 2016-09, Vol.13 (9), p.3022-3033

2016

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Clinical pharmacokinetics of atorvastatin

Clinical pharmacokinetics, 2003-01, Vol.42 (13), p.1141-1160

Lennernas, Hans

2003

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Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Molecular pharmaceutics, 2014-06, Vol.11 (6), p.1727-1738

2014

Volltextzugriff (PDF)

Animal data: The contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo

Advanced drug delivery reviews, 2007-09, Vol.59 (11), p.1103-1120

LENNERNAS, H

2007

Volltextzugriff (PDF)

ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Molecular pharmaceutics, 2020-02, Vol.17 (2), p.361-372, Article acs.molpharmaceut.9b01062

2020

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Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug

Pharmaceutical research, 2010-10, Vol.27 (10), p.2119-2130

2010

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Pharmacokinetics of an Injectable Modified-Release 2‑Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Molecular pharmaceutics, 2014-09, Vol.11 (9), p.3097-3111

2014

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High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Molecular pharmaceutics, 2010-10, Vol.7 (5), p.1827-1834

2010

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Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Clinical endocrinology (Oxford), 2015-01, Vol.82 (1), p.2-11

2015

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Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

European journal of pharmaceutical sciences, 2022-05, Vol.172, p.106150-106150, Article 106150

2022

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Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Drug discovery today, 2012-08, Vol.17 (15-16), p.905-912

2012

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Regional intestinal drug permeation: Biopharmaceutics and drug development

Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

The Fraction Dose Absorbed, in Humans, and High Jejunal Human Permeability Relationship

Direct In Vivo Human Intestinal Permeability (Peff) Determined with Different Clinical Perfusion and Intubation Methods

Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Toward an Increased Understanding of the Barriers to Colonic Drug Absorption in Humans: Implications for Early Controlled Release Candidate Assessment

Regional Intestinal Permeability of Three Model Drugs in Human

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Clinical pharmacokinetics of atorvastatin

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Animal data: The contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo

ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug

Pharmacokinetics of an Injectable Modified-Release 2‑Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

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