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Molecular Mechanisms of the Cardiotoxicity of the Proteasomal-Targeted Drugs Bortezomib and Carfilzomib

Cardiovascular toxicology, 2017-07, Vol.17 (3), p.237-250

2017

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Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs

Molecules (Basel, Switzerland), 2018-08, Vol.23 (8), p.2041

2018

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The use of dexrazoxane for the prevention of anthracycline extravasation injury

Expert opinion on investigational drugs, 2008-02, Vol.17 (2), p.217-223

Hasinoff, Brian B

2008

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Disulfiram is a slow-binding partial noncompetitive inhibitor of 20S proteasome activity

Archives of biochemistry and biophysics, 2017-11, Vol.633, p.23-28

2017

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Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform

The Journal of pharmacology and experimental therapeutics, 2016-02, Vol.356 (2), p.397

2016

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A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II

Bioorganic & medicinal chemistry, 2010-01, Vol.18 (2), p.830-838

2010

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The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II)

Journal of inorganic biochemistry, 2014-08, Vol.137, p.22-30

2014

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The Myocyte-Damaging Effects of the BCR-ABL1-Targeted Tyrosine Kinase Inhibitors Increase with Potency and Decrease with Specificity

Cardiovascular toxicology, 2017-07, Vol.17 (3), p.297-306

2017

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Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II)

Journal of inorganic biochemistry, 2013-09, Vol.126, p.1-6

2013

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Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F

Free radical biology & medicine, 2007-10, Vol.43 (8), p.1132-1144

2007

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Total Synthesis of Isoprekinamycin: Structural Evidence for Enhanced Diazonium Ion Character and Growth Inhibitory Activity toward Cancer Cells

Organic letters, 2007-07, Vol.9 (15), p.2915-2918

2007

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Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II)

Biochemical pharmacology, 2015-02, Vol.93 (3), p.266-276

2015

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The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II

Biochemical pharmacology, 2012-12, Vol.84 (12), p.1617-1626

2012

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The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα

Biochemical pharmacology, 2012-07, Vol.84 (1), p.52-58

2012

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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin–N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA

Bioorganic & medicinal chemistry, 2014-11, Vol.22 (21), p.5935-5949

2014

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Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3542-3551

2015

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Cadmium is a catalytic inhibitor of DNA topoisomerase II

Journal of inorganic biochemistry, 2011-06, Vol.105 (6), p.833-838

2011

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Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?

Cardiovascular toxicology, 2007-06, Vol.7 (2), p.140-144

2007

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Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

Bioorganic & medicinal chemistry, 2011-12, Vol.19 (23), p.7023-7032

2011

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Cell lysis with dimethyl sulphoxide produces stable homogeneous solutions in the dichlorofluorescein oxidative stress assay

Free radical research, 2008-05, Vol.42 (5), p.435-441

2008

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Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood

Drug metabolism and disposition, 2005-06, Vol.33 (6), p.719

2005

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Kinamycin F downregulates cyclin D3 in human leukemia K562 cells

Chemico-biological interactions, 2010-03, Vol.184 (3), p.396-402

2010

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The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells

Free radical research, 2006-09, Vol.40 (9), p.974-978

2006

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Thiol-Modulated Mechanisms of the Cytotoxicity of Thimerosal and Inhibition of DNA Topoisomerase IIα

Chemical research in toxicology, 2008-02, Vol.21 (2), p.483-493

2008

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Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (11), p.3974-3984

2010

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Molecular Mechanisms of the Cardiotoxicity of the Proteasomal-Targeted Drugs Bortezomib and Carfilzomib

Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs

The use of dexrazoxane for the prevention of anthracycline extravasation injury

Disulfiram is a slow-binding partial noncompetitive inhibitor of 20S proteasome activity

Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform

A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II

The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II)

The Myocyte-Damaging Effects of the BCR-ABL1-Targeted Tyrosine Kinase Inhibitors Increase with Potency and Decrease with Specificity

Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II)

Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F

Total Synthesis of Isoprekinamycin: Structural Evidence for Enhanced Diazonium Ion Character and Growth Inhibitory Activity toward Cancer Cells

Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II)

The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II

The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα

Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin–N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA

Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs

Cadmium is a catalytic inhibitor of DNA topoisomerase II

Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?

Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

Cell lysis with dimethyl sulphoxide produces stable homogeneous solutions in the dichlorofluorescein oxidative stress assay

Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood

Kinamycin F downregulates cyclin D3 in human leukemia K562 cells

The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells

Thiol-Modulated Mechanisms of the Cytotoxicity of Thimerosal and Inhibition of DNA Topoisomerase IIα

Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

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