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Structure and selectivity in bestrophin ion channels

Science (American Association for the Advancement of Science), 2014-10, Vol.346 (6207), p.355-359

2014

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Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels

PloS one, 2012-05, Vol.7 (5), p.e37079-e37079

2012

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Structural mechanism of ligand activation in human calcium-sensing receptor

eLife, 2016-07, Vol.5 (2016)

2016

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Potassium channels in the heart: structure, function and regulation

The Journal of physiology, 2017-04, Vol.595 (7), p.2209-2228

2017

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BIN1 localizes the L-type calcium channel to cardiac T-tubules

PLoS biology, 2010-02, Vol.8 (2), p.e1000312-e1000312

2010

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Preassociated apocalmodulin mediates Ca²⁺-dependent sensitization of activation and inactivation of TMEM16A/16B Ca²⁺-gated Cl⁻ channels

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18213-18218

2014

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LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms

Cardiovascular research, 2014-12, Vol.104 (3), p.501-511

2014

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Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (38), p.15461-15466

2013

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David T. Yue: In Memoriam

Neuron (Cambridge, Mass.), 2015-03, Vol.85 (6), p.1158-1161

2015

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hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms

Heart rhythm, 2016-05, Vol.13 (5), p.1121-1130

2016

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Regulation of voltage-dependent calcium channels by RGK proteins

Biochimica et biophysica acta, 2013-07, Vol.1828 (7), p.1644-1654

2013

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L-type calcium channel targeting and local signalling in cardiac myocytes

Cardiovascular research, 2013-05, Vol.98 (2), p.177-186

2013

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Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies

Nature methods, 2020-12, Vol.17 (12), p.1245-1253

2020

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The 2019 FASEB Science Research Conference on Ion Channel Regulation: Molecules to Disease, July 7‐12, 2019, Lisbon, Portugal

The FASEB journal, 2020-04, Vol.34 (4), p.4828-4831

2020

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Ion Channel Engineering: Perspectives and Strategies

Journal of molecular biology, 2015-01, Vol.427 (1), p.190-204

2015

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Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons

Science translational medicine, 2023-01, Vol.15 (679), p.eadd4666

2023

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Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Ca(V)1.2) channels

The Journal of physiology, 2011-09, Vol.589 (Pt 18), p.4437

2011

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Gating movements and ion permeation in HCN4 pacemaker channels

Molecular cell, 2021-07, Vol.81 (14), p.2929-2943.e6

2021

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Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking

The Journal of clinical investigation, 2019-02, Vol.129 (2), p.647-658

2019

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A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary Ca V β subunits

eLife, 2019-08, Vol.8

2019

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Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase

The Journal of physiology, 2010-05, Vol.588 (10), p.1665-1681

2010

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Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (47), p.12051-12056

2018

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Calmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channels

Channels (Austin, Tex.), 2016, Vol.10 (1), p.38-44

2016

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Bio-inspired voltage-dependent calcium channel blockers

Nature communications, 2013-10, Vol.4 (1), p.2540-2540, Article 2540

2013

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Adrenergic Ca V 1.2 Activation via Rad Phosphorylation Converges at α 1C I-II Loop

Circulation research, 2021-01, Vol.128 (1), p.76-88

2021

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Structure and selectivity in bestrophin ion channels

Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels

Structural mechanism of ligand activation in human calcium-sensing receptor

Potassium channels in the heart: structure, function and regulation

BIN1 localizes the L-type calcium channel to cardiac T-tubules

Preassociated apocalmodulin mediates Ca²⁺-dependent sensitization of activation and inactivation of TMEM16A/16B Ca²⁺-gated Cl⁻ channels

LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms

Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing

David T. Yue: In Memoriam

hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms

Regulation of voltage-dependent calcium channels by RGK proteins

L-type calcium channel targeting and local signalling in cardiac myocytes

Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies

The 2019 FASEB Science Research Conference on Ion Channel Regulation: Molecules to Disease, July 7‐12, 2019, Lisbon, Portugal

Ion Channel Engineering: Perspectives and Strategies

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons

Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Ca(V)1.2) channels

Gating movements and ion permeation in HCN4 pacemaker channels

Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking

A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary Ca V β subunits

Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase

Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels

Calmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channels

Bio-inspired voltage-dependent calcium channel blockers

Adrenergic Ca V 1.2 Activation via Rad Phosphorylation Converges at α 1C I-II Loop

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