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Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito

Current medicinal chemistry, 2017-08, Vol.24 (27), p.2946

2017

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Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.811-819

2014

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Structural genomics for drug design against the pathogen Coxiella burnetii

Proteins, structure, function, and bioinformatics, 2015-12, Vol.83 (12), p.2124-2136

2015

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Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance

Structure (London), 2018-01, Vol.26 (1), p.130-136.e2

2018

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3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae

Bioorganic & medicinal chemistry, 2015-03, Vol.23 (6), p.1321-1340

2015

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Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)

The Journal of pharmacology and experimental therapeutics, 2008-11, Vol.327 (2), p.573

2008

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Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (20), p.4405-4411

2015

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Toxicology of potassium channel-directed compounds in mosquitoes

Neurotoxicology (Park Forest South), 2017-05, Vol.60, p.214-223

2017

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Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue

Journal of molecular neuroscience, 2015-04, Vol.55 (4), p.1014-1021

2015

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Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates

International journal of environmental research and public health, 2019-04, Vol.16 (9), p.1500

2019

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Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease

Current pharmaceutical design, 2004-10, Vol.10 (25), p.3141

2004

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Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (14), p.4593-4598

2012

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Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer’s BACE1 inhibitors

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3992-3996

2011

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Aryl methylcarbamates: Potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae

Chemico-biological interactions, 2013-03, Vol.203 (1), p.314-318

2013

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Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae

Chemico-biological interactions, 2008-09, Vol.175 (1), p.368-375

2008

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Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group

Bioorganic & medicinal chemistry letters, 1998-03, Vol.8 (5), p.487-492

1998

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Contribution of stent underexpansion to recurrence after sirolimus-eluting stent implantation for in-stent restenosis

Circulation (New York, N.Y.), 2004-03, Vol.109 (9), p.1085-1088

2004

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Effects of psychotherapy on regional cerebral blood flow during trauma imagery in patients with post-traumatic stress disorder: a randomized clinical trial

Psychological medicine, 2008-04, Vol.38 (4), p.543-554

2008

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Emotional or educational debriefing after psychological trauma: Randomised controlled trial

British journal of psychiatry, 2006-08, Vol.189 (2), p.150-155

2006

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Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation

Psychological medicine, 2005-10, Vol.35 (10), p.1421-1431

2005

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Cortisol, Learning, Memory, and Attention in Relation to Smaller Hippocampal Volume in Police Officers with Posttraumatic Stress Disorder

Biological psychiatry (1969), 2006-01, Vol.59 (2), p.171-177

2006

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Ixekizumab treatment and the impact on SF-36: results from three pivotal phase III randomised controlled trials in patients with moderate-to-severe plaque psoriasis

Quality of life research, 2020-02, Vol.29 (2), p.369-380

2020

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The structure of acute posttraumatic stress symptoms: ‘Reexperiencing’, ‘Active avoidance’, ‘Dysphoria’, and ‘Hyperarousal’

Journal of anxiety disorders, 2009-06, Vol.23 (5), p.656-659

2009

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The structure of peritraumatic dissociation: A cross validation in clinical and nonclinical samples

Journal of traumatic stress, 2012-08, Vol.25 (4), p.475-479

2012

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The influence of occupational debriefing on post-traumatic stress symptomatology in traumatized police officers

British Journal of Medical Psychology, 2000-03, Vol.73 (1), p.87-98

2000

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Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito

Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

Structural genomics for drug design against the pathogen Coxiella burnetii

Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance

3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae

Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)

Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase

Toxicology of potassium channel-directed compounds in mosquitoes

Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue

Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates

Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase

Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer’s BACE1 inhibitors

Aryl methylcarbamates: Potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae

Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae

Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group

Contribution of stent underexpansion to recurrence after sirolimus-eluting stent implantation for in-stent restenosis

Effects of psychotherapy on regional cerebral blood flow during trauma imagery in patients with post-traumatic stress disorder: a randomized clinical trial

Emotional or educational debriefing after psychological trauma: Randomised controlled trial

Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation

Cortisol, Learning, Memory, and Attention in Relation to Smaller Hippocampal Volume in Police Officers with Posttraumatic Stress Disorder

Ixekizumab treatment and the impact on SF-36: results from three pivotal phase III randomised controlled trials in patients with moderate-to-severe plaque psoriasis

The structure of acute posttraumatic stress symptoms: ‘Reexperiencing’, ‘Active avoidance’, ‘Dysphoria’, and ‘Hyperarousal’

The structure of peritraumatic dissociation: A cross validation in clinical and nonclinical samples

The influence of occupational debriefing on post-traumatic stress symptomatology in traumatized police officers

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