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Dose/exposure–response modeling in dose titration trials: Overcoming the titration paradox

CPT: pharmacometrics and systems pharmacology, 2022-12, Vol.11 (12), p.1592-1603

2022

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Pharmacokinetics and Pharmacodynamics of Once-Weekly Somapacitan in Children and Adults: Supporting Dosing Rationales with a Model-Based Analysis of Three Phase I Trials

Clinical pharmacokinetics, 2019-01, Vol.58 (1), p.63-75

2019

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Optimal Monitoring of Weekly IGF-I Levels During Growth Hormone Therapy With Once-Weekly Somapacitan

The journal of clinical endocrinology and metabolism, 2021-02, Vol.106 (2), p.567-576

2021

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Population Pharmacokinetics and Pharmacodynamics of Once-Daily Growth Hormone Norditropin® in Children and Adults

Clinical pharmacokinetics, 2021-09, Vol.60 (9), p.1217-1226

2021

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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of a Single-Dose of NN2211, a Long-Acting Glucagon-Like Peptide 1 Derivative, in Healthy Male Subjects

Diabetes care, 2002-08, Vol.25 (8), p.1398-1404

2002

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Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes

Diabetes (New York, N.Y.), 2002-02, Vol.51 (2), p.424-429

2002

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Nephrectomized and Hepatectomized Animal Models as Tools in Preclinical Pharmacokinetics

Basic & clinical pharmacology & toxicology, 2013-08, Vol.113 (2), p.75-86

2013

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Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz–type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor

Thrombosis research, 2014-03, Vol.133 (3), p.464-471

2014

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Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative

European journal of pharmaceutical sciences, 2003-06, Vol.19 (2), p.141-150

2003

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The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects

Regulatory peptides, 2006-12, Vol.137 (3), p.168-172

2006

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Prolonged effect of GlycoPEGylated rFVIIa (40k-PEG-rFVIIa) in rabbits correlates to activity in plasma

Thrombosis and haemostasis, 2010-07, Vol.104 (1), p.157-164

2010

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Population pharmacokinetic/pharmacodynamic (PK/PD) modelling of the hypothalamic–pituitary–gonadal axis following treatment with GnRH analogues

British journal of clinical pharmacology, 2007-06, Vol.63 (6), p.648-664

2007

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Stochastic differential equations in NONMEM: implementation, application, and comparison with ordinary differential equations

Pharmaceutical research, 2005-08, Vol.22 (8), p.1247-1258

2005

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Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients

British journal of clinical pharmacology, 2004-10, Vol.58 (4), p.352-358

2004

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Pharmacokinetics of Desmopressin Administrated as an Oral Lyophilisate Dosage Form in Children With Primary Nocturnal Enuresis and Healthy Adults

Journal of clinical pharmacology, 2006-10, Vol.46 (10), p.1204-1211

2006

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Pharmacokinetics and Pharmacodynamics of a New Formulation of Recombinant Human Growth Hormone Administered by ZomaJet 2 Vision, a New Needle-Free Device, Compared to Subcutaneous Administration Using a Conventional Syringe

Journal of clinical pharmacology, 2002-11, Vol.42 (11), p.1262-1268

2002

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Population pharmacokinetic modeling of a subcutaneous depot for GnRH antagonist degarelix

Pharmaceutical research, 2004-04, Vol.21 (4), p.574-584

2004

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Semi-mechanistic pharmacodynamic modeling for degarelix, a novel gonadotropin releasing hormone (GnRH) blocker

Journal of pharmacokinetics and pharmacodynamics, 2006-10, Vol.33 (5), p.609-634

2006

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Pharmacokinetic and Pharmacodynamic Modeling of NN703, a Growth Hormone Secretagogue, after a Single po Dose to Human Volunteers

Journal of clinical pharmacology, 2001-02, Vol.41 (2), p.163-169

2001

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Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers

Pharmaceutical research, 1999-09, Vol.16 (9), p.1412-1416

1999

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Lack of Pharmacokinetic Interaction between Tiagabine and Erythromycin

Journal of clinical pharmacology, 1998-11, Vol.38 (11), p.1051-1056

1998

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Pharmacokinetics of the rapid-acting insulin analog, insulin aspart, in rats, dogs, and pigs, and pharmacodynamics of insulin aspart in pigs

Drug metabolism and disposition, 2000-02, Vol.28 (2), p.155

2000

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Penetration of amoxycillin into the respiratory tract tissues and secretions in pigs

Research in veterinary science, 1998-05, Vol.64 (3), p.245-250

1998

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Pharmacokinetic/pharmacodynamic modelling of GnRH antagonist degarelix : A comparison of the non-linear mixed-effects programs NONMEM and NLME

Journal of pharmacokinetics and pharmacodynamics, 2004-12, Vol.31 (6), p.441-461

2004

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Dose/exposure–response modeling in dose titration trials: Overcoming the titration paradox

Pharmacokinetics and Pharmacodynamics of Once-Weekly Somapacitan in Children and Adults: Supporting Dosing Rationales with a Model-Based Analysis of Three Phase I Trials

Optimal Monitoring of Weekly IGF-I Levels During Growth Hormone Therapy With Once-Weekly Somapacitan

Population Pharmacokinetics and Pharmacodynamics of Once-Daily Growth Hormone Norditropin® in Children and Adults

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of a Single-Dose of NN2211, a Long-Acting Glucagon-Like Peptide 1 Derivative, in Healthy Male Subjects

Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes

Nephrectomized and Hepatectomized Animal Models as Tools in Preclinical Pharmacokinetics

Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz–type protease inhibitor 2 domain of Tissue Factor Pathway Inhibitor

Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide

Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative

The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects

Prolonged effect of GlycoPEGylated rFVIIa (40k-PEG-rFVIIa) in rabbits correlates to activity in plasma

Population pharmacokinetic/pharmacodynamic (PK/PD) modelling of the hypothalamic–pituitary–gonadal axis following treatment with GnRH analogues

Stochastic differential equations in NONMEM: implementation, application, and comparison with ordinary differential equations

Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients

Pharmacokinetics of Desmopressin Administrated as an Oral Lyophilisate Dosage Form in Children With Primary Nocturnal Enuresis and Healthy Adults

Pharmacokinetics and Pharmacodynamics of a New Formulation of Recombinant Human Growth Hormone Administered by ZomaJet 2 Vision, a New Needle-Free Device, Compared to Subcutaneous Administration Using a Conventional Syringe

Population pharmacokinetic modeling of a subcutaneous depot for GnRH antagonist degarelix

Semi-mechanistic pharmacodynamic modeling for degarelix, a novel gonadotropin releasing hormone (GnRH) blocker

Pharmacokinetic and Pharmacodynamic Modeling of NN703, a Growth Hormone Secretagogue, after a Single po Dose to Human Volunteers

Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers

Lack of Pharmacokinetic Interaction between Tiagabine and Erythromycin

Pharmacokinetics of the rapid-acting insulin analog, insulin aspart, in rats, dogs, and pigs, and pharmacodynamics of insulin aspart in pigs

Penetration of amoxycillin into the respiratory tract tissues and secretions in pigs

Pharmacokinetic/pharmacodynamic modelling of GnRH antagonist degarelix : A comparison of the non-linear mixed-effects programs NONMEM and NLME

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