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Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

European journal of drug metabolism and pharmacokinetics, 2000-01, Vol.25 (1), p.49-58

2000

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Role of modelling and simulation in Phase I drug development

European journal of pharmaceutical sciences, 2001-05, Vol.13 (2), p.115-122

2001

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The use of population pharmacokinetics in drug development

Clinical pharmacokinetics, 1996-02, Vol.30 (2), p.81-93

1996

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An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche

Clinical pharmacokinetics, 1997-08, Vol.33 (2), p.142-152

1997

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Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

International journal of clinical pharmacology and therapeutics, 1997-10, Vol.35 (10), p.469

1997

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Pharmacokinetic and pharmacodynamic data and models in clinical trials

European journal of drug metabolism and pharmacokinetics, 1993-01, Vol.18 (1), p.61-76

1993

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Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

Clinical pharmacokinetics, 1985-01, Vol.10 (6), p.457-476

1985

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New strategies in drug development and clinical evaluation : the population approach : commentary on an action for co-operative research

European journal of clinical pharmacology, 1993-09, Vol.45 (2), p.93-94

1993

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A mathematical model for dynamics of cardiovascular drug action : application to intravenous dihydropyridines in healthy volunteers

Journal of pharmacokinetics and biopharmaceutics, 1993-10, Vol.21 (5), p.489-514

1993

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Pharmacokinetic aspects of the sublingual administration of vincamine

Biopharmaceutics & drug disposition, 1990-05, Vol.11 (4), p.279-309

1990

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Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine

Journal of pharmacokinetics and biopharmaceutics, 1988-06, Vol.16 (3), p.311-327

1988

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Sparse-Sampling Optimal Designs in Pharmacokinetics and Toxicokinetics

Therapeutic innovation & regulatory science, 1995, Vol.29 (3), p.997-1019

1995

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An analytical solution for a class of delay-differential equations in pharmacokinetic compartment modeling

Mathematical biosciences, 1984-01, Vol.70 (1), p.39-56

1984

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Pharmacometrics : modelling and simulation tools to improve decision making in clinical drug development

Role of modelling and simulation in Phase I drug development

The use of population pharmacokinetics in drug development

An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche

Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

Pharmacokinetic and pharmacodynamic data and models in clinical trials

Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application

New strategies in drug development and clinical evaluation : the population approach : commentary on an action for co-operative research

A mathematical model for dynamics of cardiovascular drug action : application to intravenous dihydropyridines in healthy volunteers

Pharmacokinetic aspects of the sublingual administration of vincamine

Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine

Sparse-Sampling Optimal Designs in Pharmacokinetics and Toxicokinetics

An analytical solution for a class of delay-differential equations in pharmacokinetic compartment modeling

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