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Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity

Cell reports (Cambridge), 2014-05, Vol.7 (3), p.654-660

2014

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Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids

Scientific reports, 2022-04, Vol.12 (1), p.6169-6169, Article 6169

2022

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Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells

International journal of molecular sciences, 2024-01, Vol.25 (2), p.905

2024

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Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

The Journal of biological chemistry, 2018-03, Vol.293 (13), p.4870-4882

2018

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Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

Endocrine reviews, 2022-08, Vol.43 (4), p.678-719

2022

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Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network

PLoS genetics, 2021-09, Vol.17 (9), p.e1009785-e1009785

2021

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Dynamic indentation on human skin in vivo: ageing effects

Skin research and technology, 2009-02, Vol.15 (1), p.55-67

2009

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Targeting Class I Histone Deacetylases in Human Uterine Leiomyosarcoma

Cells (Basel, Switzerland), 2022-11, Vol.11 (23), p.3801

2022

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The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma

Cells (Basel, Switzerland), 2022-07, Vol.11 (14), p.2160

2022

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BRCA1 Mediates Ligand-Independent Transcriptional Repression of the Estrogen Receptor

Proceedings of the National Academy of Sciences - PNAS, 2001-08, Vol.98 (17), p.9587-9592

2001

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Effects of pregnancy on skin properties: A biomechanical approach

Skin research and technology, 2018-11, Vol.24 (4), p.551-556

2018

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Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (49), p.19678-19682

2011

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Non contact method for in vivo assessment of skin mechanical properties for assessing effect of ageing

Medical engineering & physics, 2012-03, Vol.34 (2), p.172-178

2012

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MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas

JCI insight, 2023-09, Vol.8 (18)

2023

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Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway

Endocrinology (Philadelphia), 2017-03, Vol.158 (3), p.592-603

2017

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Introduction of Somatic Mutation in MED12 Induces Wnt4/β-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell

Reproductive sciences (Thousand Oaks, Calif.), 2020-03, Vol.27 (3), p.823-832

2020

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Assessment of the in-plane biomechanical properties of human skin using a finite element model updating approach combined with an optical full-field measurement on a new tensile device

Journal of the mechanical behavior of biomedical materials, 2013-11, Vol.27, p.273-282

2013

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Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells

The journal of clinical endocrinology and metabolism, 2016-04, Vol.101 (4), p.1542-1551

2016

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Mediator and human disease

Seminars in cell & developmental biology, 2011-09, Vol.22 (7), p.776-787

2011

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Lessons learned from BRCA1 and BRCA2

Oncogene, 2000-12, Vol.19 (53), p.6159-6175

2000

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DBC-1 mediates endocrine resistant breast cancer cell survival

Cell cycle (Georgetown, Tex.), 2010-03, Vol.9 (6), p.1218-1219

2010

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Mediator kinase disruption in MED12-mutant uterine fibroids from Hispanic women of South Texas

The journal of clinical endocrinology and metabolism, 2018-11, Vol.103 (11), p.4283-4292

2018

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BRCA1 Negatively Regulates the Cancer-Associated Aromatase Promoters I.3 and II in Breast Adipose Fibroblasts and Malignant Epithelial Cells

The journal of clinical endocrinology and metabolism, 2006-11, Vol.91 (11), p.4514-4519

2006

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Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas

Human mutation, 2014-09, Vol.35 (9), p.1136-1141

2014

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Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity

Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids

Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network

Dynamic indentation on human skin in vivo: ageing effects

Targeting Class I Histone Deacetylases in Human Uterine Leiomyosarcoma

The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma

BRCA1 Mediates Ligand-Independent Transcriptional Repression of the Estrogen Receptor

Effects of pregnancy on skin properties: A biomechanical approach

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

Non contact method for in vivo assessment of skin mechanical properties for assessing effect of ageing

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms

MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas

Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway

Introduction of Somatic Mutation in MED12 Induces Wnt4/β-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell

Assessment of the in-plane biomechanical properties of human skin using a finite element model updating approach combined with an optical full-field measurement on a new tensile device

Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells

Mediator and human disease

Lessons learned from BRCA1 and BRCA2

DBC-1 mediates endocrine resistant breast cancer cell survival

Mediator kinase disruption in MED12-mutant uterine fibroids from Hispanic women of South Texas

BRCA1 Negatively Regulates the Cancer-Associated Aromatase Promoters I.3 and II in Breast Adipose Fibroblasts and Malignant Epithelial Cells

Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas

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