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Fatty Acids and Insulin Secretion: From FFAR and Near?

Diabetes (New York, N.Y.), 2018-10, Vol.67 (10), p.1932-1934

Poitout, Vincent

2018

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Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges

Nature reviews. Endocrinology, 2021-03, Vol.17 (3), p.162-175

2021

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Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

PloS one, 2012-04, Vol.7 (4), p.e36200

2012

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Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death

Diabetes (New York, N.Y.), 2010-02, Vol.59 (2), p.440-447

2010

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Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats

Diabetologia, 2017-05, Vol.60 (5), p.879-888

2017

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Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

Diabetes (New York, N.Y.), 2009-11, Vol.58 (11), p.2607-2615

2009

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Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice

The international journal of neuropsychopharmacology, 2016-07, Vol.19 (7), p.pyw014

2016

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The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding

Diabetes (New York, N.Y.), 2008-09, Vol.57 (9), p.2432-2437

2008

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GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo

Diabetes (New York, N.Y.), 2007-04, Vol.56 (4), p.1087-1094

2007

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Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (7), p.2376-2381

2012

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Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents

Arteriosclerosis, thrombosis, and vascular biology, 2013-05, Vol.33 (5), p.954-961

2013

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PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance

Diabetes (New York, N.Y.), 2001-12, Vol.50 (12), p.2809-2814

2001

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Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets

Diabetes (New York, N.Y.), 2008-02, Vol.57 (2), p.424-431

2008

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Antecedent Hyperglycemia, Not Hyperlipidemia, Is Associated With Increased Islet Triacylglycerol Content and Decreased Insulin Gene mRNA Level in Zucker Diabetic Fatty Rats

Diabetes (New York, N.Y.), 2001-11, Vol.50 (11), p.2481-2486

2001

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Evidence Against the Involvement of Oxidative Stress in Fatty Acid Inhibition of Insulin Secretion

Diabetes (New York, N.Y.), 2004-10, Vol.53 (10), p.2610-2616

2004

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Differential Effects of Hyperlipidemia on Insulin Secretion in Islets of Langerhans From Hyperglycemic Versus Normoglycemic Rats

Diabetes (New York, N.Y.), 2002-03, Vol.51 (3), p.662-668

2002

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GPR40: good cop, bad cop?

Diabetes (New York, N.Y.), 2009-05, Vol.58 (5), p.1035-1036

2009

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Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat β-Cell Proliferation

Diabetes (New York, N.Y.), 2023-01, Vol.72 (1), p.45-58

2023

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Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes?

Canadian journal of diabetes, 2012-10, Vol.36 (5), p.275-280

2012

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Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice

Endocrinology (Philadelphia), 2021-03, Vol.162 (3), p.1

2021

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2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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The autonomic nervous system regulates pancreatic β-cell proliferation in adult male rats

American journal of physiology: endocrinology and metabolism, 2019-08, Vol.317 (2), p.E234-E243

2019

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Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

Diabetes (New York, N.Y.), 2022-06, Vol.71 (6), p.1218-1232

2022

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Regulation of the Insulin Gene by Glucose and Fatty Acids

The Journal of nutrition, 2006-04, Vol.136 (4), p.873-876

2006

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Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet

American journal of physiology: endocrinology and metabolism, 2018-12, Vol.315 (6), p.E1251-E1263

2018

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Fatty Acids and Insulin Secretion: From FFAR and Near?

Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges

Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid–Induced ER Stress–Mediated β-Cell Death

Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats

Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding

GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents

PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance

Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets

Antecedent Hyperglycemia, Not Hyperlipidemia, Is Associated With Increased Islet Triacylglycerol Content and Decreased Insulin Gene mRNA Level in Zucker Diabetic Fatty Rats

Evidence Against the Involvement of Oxidative Stress in Fatty Acid Inhibition of Insulin Secretion

Differential Effects of Hyperlipidemia on Insulin Secretion in Islets of Langerhans From Hyperglycemic Versus Normoglycemic Rats

GPR40: good cop, bad cop?

Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat β-Cell Proliferation

Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes?

Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice

2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets

The autonomic nervous system regulates pancreatic β-cell proliferation in adult male rats

Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

Regulation of the Insulin Gene by Glucose and Fatty Acids

Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet

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