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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Blood, 2012-03, Vol.119 (13), p.3024-3030

2012

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Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors

Molecular therapy, 2011-03, Vol.19 (3), p.442-449

2011

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Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

Blood, 2005-04, Vol.105 (8), p.3079-3086

2005

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Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Blood, 2009-04, Vol.113 (16), p.3682-3689

2009

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Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Blood, 2009-11, Vol.114 (20), p.4562-4565

2009

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Complete correction of hemophilia B phenotype by FIX-Padua skeletal muscle gene therapy in an inhibitor-prone dog model

Blood advances, 2018-03, Vol.2 (5), p.505-508

2018

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Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

Nature medicine, 1999-01, Vol.5 (1), p.56-63

1999

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Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis

Arteriosclerosis, thrombosis, and vascular biology, 2019-11, Vol.39 (11), p.2261-2272

2019

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Animal Models of Hemophilia and Related Bleeding Disorders

Seminars in hematology, 2013-04, Vol.50 (2), p.175-184

2013

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Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B

Molecular therapy, 2010-11, Vol.18 (11), p.1896-1906

2010

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Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1

Blood, 2004-01, Vol.103 (1), p.85-92

2004

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Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury

American journal of physiology. Heart and circulatory physiology, 2003-03, Vol.284 (3), p.H919-H926

2003

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Experimental Validation of ARFI Surveillance of Subcutaneous Hemorrhage (ASSH) Using Calibrated Infusions in a Tissue-Mimicking Model and Dogs

Ultrasonic imaging, 2016-09, Vol.38 (5), p.346-358

2016

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Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogs

Human gene therapy. Clinical development, 2015-03, Vol.26 (1), p.5-14

2015

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ARFI imaging for noninvasive material characterization of atherosclerosis

Ultrasound in medicine & biology, 2006-11, Vol.32 (11), p.1703-1711

2006

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Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin

British journal of haematology, 2011-01, Vol.152 (1), p.99-107

2011

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Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency

ILAR journal, 2009, Vol.50 (2), p.144-167

2009

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Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy

Human gene therapy, 2002-07, Vol.13 (11), p.1281-1291

2002

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Animal Models of Hemophilia

Animal Models of Molecular Pathology, 2012, Vol.105, p.151-209

2012

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Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa

American journal of veterinary research, 2011-08, Vol.72 (8), p.1007-1014

2011

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Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant hemophilia B dogs

Blood, 2003-12, Vol.102 (13), p.4393-4398

2003

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Thrombotic thrombocytopenia induced in dogs and pigs. The role of plasma and platelet vWF in animal models of thrombotic thrombocytopenic purpura

Arteriosclerosis, thrombosis, and vascular biology, 1995-06, Vol.15 (6), p.793-800

1995

Volltextzugriff (PDF)

Liver-directed lentiviral gene therapy in a dog model of hemophilia B

Science translational medicine, 2015-03, Vol.7 (277), p.277ra28

2015

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[18F]FLT-PET Imaging Does Not Always Light Up Proliferating Tumor Cells

Clinical cancer research, 2012-03, Vol.18 (5), p.1303-1312

2012

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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide

Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors

Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Complete correction of hemophilia B phenotype by FIX-Padua skeletal muscle gene therapy in an inhibitor-prone dog model

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis

Animal Models of Hemophilia and Related Bleeding Disorders

Hyperactive Sleeping Beauty Transposase Enables Persistent Phenotypic Correction in Mice and a Canine Model for Hemophilia B

Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1

Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury

Experimental Validation of ARFI Surveillance of Subcutaneous Hemorrhage (ASSH) Using Calibrated Infusions in a Tissue-Mimicking Model and Dogs

Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogs

ARFI imaging for noninvasive material characterization of atherosclerosis

Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin

Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency

Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy

Animal Models of Hemophilia

Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa

Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant hemophilia B dogs

Thrombotic thrombocytopenia induced in dogs and pigs. The role of plasma and platelet vWF in animal models of thrombotic thrombocytopenic purpura

Liver-directed lentiviral gene therapy in a dog model of hemophilia B

[18F]FLT-PET Imaging Does Not Always Light Up Proliferating Tumor Cells

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