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A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia

Gene therapy, 1997-11, Vol.4 (11), p.1173-1180

1997

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Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

Nature (London), 2000-10, Vol.407 (6805), p.762-764

2000

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Synergistic and additive killing by antimicrobial factors found in human airway surface liquid

American journal of physiology. Lung cellular and molecular physiology, 2000-11, Vol.279 (5), p.799-L805

2000

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Normal Gating of CFTR Requires ATP Binding to Both Nucleotide-Binding Domains and Hydrolysis at the Second Nucleotide-Binding Domain

Proceedings of the National Academy of Sciences - PNAS, 2005-01, Vol.102 (2), p.455-460

2005

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Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR

American journal of physiology. Lung cellular and molecular physiology, 2005-12, Vol.289 (6), p.L1123-L1130

2005

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A Shortened Adeno-Associated virus Expression Cassette for CFTR Gene Transfer to Cystic Fibrosis Airway Epithelia

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (8), p.2952-2957

2005

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Antimicrobial peptides and proteins in the innate defense of the airway surface

Current Opinion in Immunology, 2001-02, Vol.13 (1), p.89-95

2001

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Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection

The Journal of clinical investigation, 1997-09, Vol.100 (5), p.1144-1149

1997

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Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

Nature (London), 1992-08, Vol.358 (6389), p.761-764

1992

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Complexes of Adenovirus with Polycationic Polymers and Cationic Lipids Increase the Efficiency of Gene Transfer in Vitro and in Vivo

The Journal of biological chemistry, 1997-03, Vol.272 (10), p.6479-6489

1997

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Regulation of CFTR Cl-Channel Gating by ATP Binding and Hydrolysis

Proceedings of the National Academy of Sciences - PNAS, 2000-07, Vol.97 (15), p.8675-8680

2000

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A Functional R Domain from Cystic Fibrosis Transmembrane Conductance Regulator Is Predominantly Unstructured in Solution

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (10), p.5657-5662

2000

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Stimulation of CFTR activity by its phosphorylated R domain

Nature (London), 1997-09, Vol.389 (6648), p.294-296

1997

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ADP Inhibits Function of the ABC Transporter Cystic Fibrosis Transmembrane Conductance Regulator via Its Adenylate Kinase Activity

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (6), p.2216-2220

2005

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Abnormal regulation of ion channels in cystic fibrosis epithelia

The FASEB journal, 1990-07, Vol.4 (10), p.2718-2725

Welsh, Michael J.

1990

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The Osmolyte Xylitol Reduces the Salt Concentration of Airway Surface Liquid and May Enhance Bacterial Killing

Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (21), p.11614-11619

2000

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Effects of C-Terminal Deletions on Cystic Fibrosis Transmembrane Conductance Regulator Function in Cystic Fibrosis Airway Epithelia

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.1937-1942

2003

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Demonstration that CFTR is a Chloride Channel by Alteration of its Anion Selectivity

Science (American Association for the Advancement of Science), 1991-07, Vol.253 (5016), p.202-205

1991

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Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo

The Journal of clinical investigation, 1998-07, Vol.102 (1), p.184-193

1998

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Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents

The Journal of general physiology, 1992-10, Vol.100 (4), p.573-591

1992

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Calcium and cAMP Activate Different Chloride Channels in the Apical Membrane of Normal and Cystic Fibrosis Epithelia

Proceedings of the National Academy of Sciences - PNAS, 1991-07, Vol.88 (14), p.6003-6007

1991

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A mouse model for the delta F508 allele of cystic fibrosis

The Journal of clinical investigation, 1995-10, Vol.96 (4), p.2051-2064

1995

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Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo

The Journal of clinical investigation, 1997-09, Vol.100 (6), p.1529-1537

1997

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Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases

The Journal of biological chemistry, 1993-01, Vol.268 (3), p.2037-2047

1993

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Generation of cAMP-Activated Chloride Currents by Expression of CFTR

Science (American Association for the Advancement of Science), 1991-02, Vol.251 (4994), p.679-682

1991

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A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia

Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

Synergistic and additive killing by antimicrobial factors found in human airway surface liquid

Normal Gating of CFTR Requires ATP Binding to Both Nucleotide-Binding Domains and Hydrolysis at the Second Nucleotide-Binding Domain

Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR

A Shortened Adeno-Associated virus Expression Cassette for CFTR Gene Transfer to Cystic Fibrosis Airway Epithelia

Antimicrobial peptides and proteins in the innate defense of the airway surface

Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

Complexes of Adenovirus with Polycationic Polymers and Cationic Lipids Increase the Efficiency of Gene Transfer in Vitro and in Vivo

Regulation of CFTR Cl-Channel Gating by ATP Binding and Hydrolysis

A Functional R Domain from Cystic Fibrosis Transmembrane Conductance Regulator Is Predominantly Unstructured in Solution

Stimulation of CFTR activity by its phosphorylated R domain

ADP Inhibits Function of the ABC Transporter Cystic Fibrosis Transmembrane Conductance Regulator via Its Adenylate Kinase Activity

Abnormal regulation of ion channels in cystic fibrosis epithelia

The Osmolyte Xylitol Reduces the Salt Concentration of Airway Surface Liquid and May Enhance Bacterial Killing

Effects of C-Terminal Deletions on Cystic Fibrosis Transmembrane Conductance Regulator Function in Cystic Fibrosis Airway Epithelia

Demonstration that CFTR is a Chloride Channel by Alteration of its Anion Selectivity

Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo

Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents

Calcium and cAMP Activate Different Chloride Channels in the Apical Membrane of Normal and Cystic Fibrosis Epithelia

A mouse model for the delta F508 allele of cystic fibrosis

Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

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