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The Mechanism of Cellulose Hydrolysis by a Two-Step, Retaining Cellobiohydrolase Elucidated by Structural and Transition Path Sampling Studies

Journal of the American Chemical Society, 2014-01, Vol.136 (1), p.321-329

2014

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Emerging methods for the production of homogeneous human glycoproteins

Nature chemical biology, 2009-04, Vol.5 (4), p.206-215

2009

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The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif

Nature chemical biology, 2015-09, Vol.11 (9), p.691-696

2015

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Glycosidase Mechanisms: Anatomy of a Finely Tuned Catalyst

Accounts of chemical research, 2000-01, Vol.33 (1), p.11-18

2000

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Substrate Engineering Enabling Fluorescence Droplet Entrapment for IVC-FACS-Based Ultrahigh-Throughput Screening

Analytical chemistry (Washington), 2016-09, Vol.88 (17), p.8587-8595

2016

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N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases

Chemical communications (Cambridge, England), 2016-01, Vol.52 (51), p.7943-7946

2016

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A Chemoenzymatic Total Synthesis of the Neurogenic Starfish Ganglioside LLG-3 Using an Engineered and Evolved Synthase

Angewandte Chemie (International ed.), 2012-08, Vol.51 (34), p.8640-8643

International ed. in English, 2012

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Trypanosoma cruzi Trans-sialidase Operates through a Covalent Sialyl−Enzyme Intermediate: Tyrosine Is the Catalytic Nucleophile

Journal of the American Chemical Society, 2003-06, Vol.125 (25), p.7532-7533

2003

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A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening

Angewandte Chemie (International ed.), 2015-04, Vol.54 (18), p.5389-5393

International ed. in English, 2015

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New approaches to enzymatic glycoside synthesis through directed evolution

Carbohydrate research, 2010-07, Vol.345 (10), p.1272-1279

2010

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Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution

Journal of the American Chemical Society, 2015-05, Vol.137 (17), p.5695-5705

2015

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N -Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase

Molecules (Basel, Switzerland), 2020-10, Vol.25 (20), p.4618

2020

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Fluorescence Activated Cell Sorting as a General Ultra-High-Throughput Screening Method for Directed Evolution of Glycosyltransferases

Journal of the American Chemical Society, 2010-08, Vol.132 (30), p.10570-10577

2010

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Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity

Angewandte Chemie (International ed.), 2011-01, Vol.50 (1), p.300-303

International ed. in English, 2011

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The Staudinger/aza-Wittig/Grignard reaction as key step for the concise synthesis of 1-C-Alkyl-iminoalditol glycomimetics

Carbohydrate research, 2016-06, Vol.429, p.62-70

2016

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Mechanistic analogies amongst carbohydrate modifying enzymes

Chemical communications (Cambridge, England), 2004-10 (20), p.2243-2248

2004

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Mechanisms of glycosyl transferases and hydrolases

Carbohydrate polymers, 2001-04, Vol.44 (4), p.325-337

Withers, S.G

2001

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Understanding viral neuraminidase inhibition by substituted difluorosialic acids

Chemical communications (Cambridge, England), 2015-02, Vol.51 (14), p.2933-2935

2015

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Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.708

2018

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Tuning Mechanism-Based Inactivators of Neuraminidases: Mechanistic and Structural Insights

Angewandte Chemie (International ed.), 2014-03, Vol.53 (13), p.3382-3386

International ed. in English, 2014

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Ultrasensitive Fluorogenic Reagents for Neuraminidase Titration

Angewandte Chemie International Edition, 2017-05, Vol.56 (22), p.6112-6116

International ed. in English, 2017

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Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase

Chemical communications (Cambridge, England), 2011-01, Vol.47 (38), p.10806-10808

2011

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7‑Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins

ACS central science, 2021-02, Vol.7 (2), p.345-354

2021

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Tailoring the Specificity and Reactivity of a Mechanism-Based Inactivator of Glucocerebrosidase for Potential Therapeutic Applications

Angewandte Chemie (International ed.), 2011-10, Vol.50 (44), p.10381-10383

International ed. in English, 2011

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Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy

Bioorganic & medicinal chemistry letters, 2014-06, Vol.24 (12), p.2777-2780

2014

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The Mechanism of Cellulose Hydrolysis by a Two-Step, Retaining Cellobiohydrolase Elucidated by Structural and Transition Path Sampling Studies

Emerging methods for the production of homogeneous human glycoproteins

The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif

Glycosidase Mechanisms: Anatomy of a Finely Tuned Catalyst

Substrate Engineering Enabling Fluorescence Droplet Entrapment for IVC-FACS-Based Ultrahigh-Throughput Screening

N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases

A Chemoenzymatic Total Synthesis of the Neurogenic Starfish Ganglioside LLG-3 Using an Engineered and Evolved Synthase

Trypanosoma cruzi Trans-sialidase Operates through a Covalent Sialyl−Enzyme Intermediate: Tyrosine Is the Catalytic Nucleophile

A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening

New approaches to enzymatic glycoside synthesis through directed evolution

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution

N -Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase

Fluorescence Activated Cell Sorting as a General Ultra-High-Throughput Screening Method for Directed Evolution of Glycosyltransferases

Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity

The Staudinger/aza-Wittig/Grignard reaction as key step for the concise synthesis of 1-C-Alkyl-iminoalditol glycomimetics

Mechanistic analogies amongst carbohydrate modifying enzymes

Mechanisms of glycosyl transferases and hydrolases

Understanding viral neuraminidase inhibition by substituted difluorosialic acids

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Tuning Mechanism-Based Inactivators of Neuraminidases: Mechanistic and Structural Insights

Ultrasensitive Fluorogenic Reagents for Neuraminidase Titration

Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase

7‑Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins

Tailoring the Specificity and Reactivity of a Mechanism-Based Inactivator of Glucocerebrosidase for Potential Therapeutic Applications

Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy

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