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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Nucleic acids research, 2007-01, Vol.35 (2), p.687-700

2007

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Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Bioconjugate chemistry, 2015-08, Vol.26 (8), p.1451-1455

2015

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Alternative Syntheses of (S)‑cEt-BNA: A Key Constrained Nucleoside Component of Bioactive Antisense Gapmer Sequences

Journal of organic chemistry, 2014-12, Vol.79 (23), p.11651-11660

2014

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Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4127-4130

2015

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A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (9), p.2194-2197

2016

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Interaction of ASOs with PC4 Is Highly Influenced by the Cellular Environment and ASO Chemistry

Journal of the American Chemical Society, 2020-05, Vol.142 (21), p.9661-9674, Article jacs.0c01808

2020

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Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA

Journal of organic chemistry, 2023-03, Vol.88 (6), p.3599-3614

2023

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Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA

Journal of the American Chemical Society, 2022-02, Vol.144 (4), p.1941-1950

2022

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Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues

Journal of organic chemistry, 2010-03, Vol.75 (5), p.1569-1581

2010

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Synthesis and Biophysical Properties of Constrained d‑Altritol Nucleic Acids (cANA)

Organic letters, 2013-09, Vol.15 (17), p.4316-4319

2013

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Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7097-7101

2010

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Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Angewandte Chemie International Edition, 2007-04, Vol.46 (17), p.2971-2971

2007

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Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Angewandte Chemie International Edition, 2004-12, Vol.43 (48), p.6735-6738

2004

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Aryl urea analogs with broad-spectrum antibacterial activity

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5569-5572

2004

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A Solid-Phase Synthesis of N,N‘-Disubstituted Ureas and Perhydroimidazo[1,5-a]pyrazines via the Curtius Rearrangement

Organic letters, 2000-10, Vol.2 (21), p.3309-3311

2000

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An Efficient Synthesis of Gougerotin and Related Analogues Using Solid- and Solution-Phase Methodology

Organic letters, 2005-08, Vol.7 (16), p.3429-3432

2005

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The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (22), p.4919-4922

2005

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Synthesis and Unusual Chemical Reactivity of Certain Novel 4,5-Disubstituted 7-Benzylpyrrolo[2,3-d][1,2,3]triazines

Journal of organic chemistry, 2001-07, Vol.66 (14), p.4776-4782

2001

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Scalable synthesis of substituted 2,7-dimethyl-9-phenylxanthen-9-ol (DMPx-OH): useful for the preparation of crystalline 5′-O-DMPx-protected nucleosides

Tetrahedron letters, 2012-08, Vol.53 (35), p.4669-4672

2012

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A Two Step Synthesis of the Nucleoside Q Precursor 2-Amino-5-cyanopyrrolo[2,3-d]pyrimidin 4-one (PreQo)

Synthetic communications, 1996-09, Vol.26 (17), p.3317-3322

1996

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Probing the ribosomal RNA A-site with functionally diverse analogues of paromomycin—synthesis of ring I mimetics

Tetrahedron, 2007-01, Vol.63 (4), p.827-846

2007

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Synthesis and Biophysical Evaluation of 2',4'-Constrained 2'O-Methoxyethyl and 2',4'-Constrained 2'O-Ethyl Nucleic Acid Analogues

Journal of organic chemistry, 2010-03, Vol.75 (5), p.1569-1581

2010

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An Efficient Synthesis of 2-Nitropyrrole-3,4-dicarboxamide

Synthetic communications, 1999-11, Vol.29 (21), p.3757-3772

1999

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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Alternative Syntheses of (S)‑cEt-BNA: A Key Constrained Nucleoside Component of Bioactive Antisense Gapmer Sequences

Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry

A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid

Interaction of ASOs with PC4 Is Highly Influenced by the Cellular Environment and ASO Chemistry

Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA

Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues

Synthesis and Biophysical Properties of Constrained d‑Altritol Nucleic Acids (cANA)

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Aryl urea analogs with broad-spectrum antibacterial activity

A Solid-Phase Synthesis of N,N‘-Disubstituted Ureas and Perhydroimidazo[1,5-a]pyrazines via the Curtius Rearrangement

An Efficient Synthesis of Gougerotin and Related Analogues Using Solid- and Solution-Phase Methodology

The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides

Synthesis and Unusual Chemical Reactivity of Certain Novel 4,5-Disubstituted 7-Benzylpyrrolo[2,3-d][1,2,3]triazines

Scalable synthesis of substituted 2,7-dimethyl-9-phenylxanthen-9-ol (DMPx-OH): useful for the preparation of crystalline 5′-O-DMPx-protected nucleosides

A Two Step Synthesis of the Nucleoside Q Precursor 2-Amino-5-cyanopyrrolo[2,3-d]pyrimidin 4-one (PreQo)

Probing the ribosomal RNA A-site with functionally diverse analogues of paromomycin—synthesis of ring I mimetics

Synthesis and Biophysical Evaluation of 2',4'-Constrained 2'O-Methoxyethyl and 2',4'-Constrained 2'O-Ethyl Nucleic Acid Analogues

An Efficient Synthesis of 2-Nitropyrrole-3,4-dicarboxamide

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