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Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Angewandte Chemie (International ed.), 2016-08, Vol.55 (33), p.9758-9762

International ed. in English, 2016

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Enantioselective Single and Dual α‑C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Journal of the American Chemical Society, 2023-01, Vol.145 (1), p.537-550

2023

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Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

Organic process research & development, 2022-03, Vol.26 (3), p.616-623

2022

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Expedient synthesis of novel β-ketoesters from the Mizoroki–Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides

Tetrahedron letters, 2013-12, Vol.54 (51), p.7065-7068

2013

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Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012-11, Vol.77 (22), p.10050-10057

2012

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Novel and selective spiroindoline-based inhibitors of sky kinase

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.190-193

2012

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Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1051-1055

2013

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Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1046-1050

2013

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Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Angewandte Chemie, 2016-08, Vol.128 (33), p.9910-9914

2016

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Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2501-2511

2009

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Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5567-5572

2007

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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Organic process research & development, 2023-05, Vol.27 (5), p.854-865

2023

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The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.1060-1064

2006

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The discovery of glycine and related amino acid-based factor Xa inhibitors

Bioorganic & medicinal chemistry, 2006-07, Vol.14 (13), p.4379-4392

2006

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The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4752-4756

2005

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Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Organic process research & development, 2021-06, Vol.25 (6), p.1440-1453

2021

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Highly Functionalized Cyclohexenyl Systems: Enzymatic Resolution and Selective Oxirane Opening Reactions of p-Benzoquinone Derivatives

Journal of organic chemistry, 1998-07, Vol.63 (15), p.5088-5093

1998

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Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (19), p.5410-5414

2013

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A versatile copper-catalyzed coupling reaction of pyridin-2(1 H)-ones with aryl halides

Tetrahedron letters, 2006-10, Vol.47 (44), p.7677-7680

2006

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Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2943-2947

2012

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An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

Tetrahedron letters, 2000, Vol.41 (32), p.6041-6044

2000

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Model Studies on the Synthesis of Hennoxazole A

Synlett, 1995-05, Vol.1995 (5), p.415-416

1995

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FUSED PYRAZOLE SYNTHESIS BY N-N BOND FORMATION: THE PYRAZOLO[5,1-b]BENZOTHIAZOLE SYSTEM

Heterocyclic communications, 1997, Vol.3 (3), p.201-206

1997

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Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Enantioselective Single and Dual α‑C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

Expedient synthesis of novel β-ketoesters from the Mizoroki–Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Novel and selective spiroindoline-based inhibitors of sky kinase

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

The discovery of glycine and related amino acid-based factor Xa inhibitors

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Highly Functionalized Cyclohexenyl Systems: Enzymatic Resolution and Selective Oxirane Opening Reactions of p-Benzoquinone Derivatives

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

A versatile copper-catalyzed coupling reaction of pyridin-2(1 H)-ones with aryl halides

Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists

An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

Model Studies on the Synthesis of Hennoxazole A

FUSED PYRAZOLE SYNTHESIS BY N-N BOND FORMATION: THE PYRAZOLO[5,1-b]BENZOTHIAZOLE SYSTEM

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