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L-Type amino acid transporter 1 as a target for drug delivery

Pharmaceutical research, 2020-05, Vol.37 (5), p.88-88, Article 88

2020

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L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

Journal of controlled release, 2017-09, Vol.261, p.93-104

2017

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Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Pharmaceutical research, 2022-07, Vol.39 (7), p.1363-1392

2022

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The Role of Transporters in Future Chemotherapy

Chimia, 2022-05, Vol.76 (5), p.454

2022

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Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

Molecules (Basel, Switzerland), 2022-12, Vol.27 (23), p.8531

2022

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Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin

International journal of molecular sciences, 2022-04, Vol.23 (8), p.4132

2022

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Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5642

2021

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Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Molecules (Basel, Switzerland), 2021-12, Vol.27 (1), p.37

2021

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Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

International journal of molecular sciences, 2021-07, Vol.22 (14), p.7727

2021

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Effective Cellular Transport of Ortho -Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

International journal of molecular sciences, 2020-03, Vol.21 (7), p.2389

2020

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Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

Molecules (Basel, Switzerland), 2019-12, Vol.25 (1), p.125

2019

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Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Molecules (Basel, Switzerland), 2021-09, Vol.26 (18), p.5662

2021

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Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation

Bioorganic chemistry, 2021-07, Vol.112, p.104921, Article 104921

2021

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Metformin - a Future Therapy for Neurodegenerative Diseases

Pharmaceutical research, 2017-12, Vol.34 (12), p.2614-2627

2017

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Sulfenamide derivatives can improve transporter-mediated cellular uptake of metformin and induce cytotoxicity in human breast adenocarcinoma cell lines

Bioorganic chemistry, 2019-06, Vol.87, p.321-334

2019

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Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Pharmaceutical research, 2019-01, Vol.36 (1), p.17-8, Article 17

2019

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Sustained Release of Metformin via Red Blood Cell Accumulated Sulfenamide Prodrug

Journal of pharmaceutical sciences, 2014-07, Vol.103 (7), p.2207-2210

2014

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Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug

Bioorganic & medicinal chemistry letters, 2018-09, Vol.28 (17), p.2856-2860

2018

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Novel halogenated sulfonamide biguanides with anti-coagulation properties

Bioorganic chemistry, 2020-01, Vol.94, p.103444, Article 103444

2020

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Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug

Bioorganic & medicinal chemistry letters, 2014-11, Vol.24 (21), p.5034-5036

2014

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Benzenesulphonamide inhibitors of the cytolytic protein perforin

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.1050-1054

2017

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Diarylthiophenes as inhibitors of the pore-forming protein perforin

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.355-360

2016

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Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography

Journal of pharmaceutical and biomedical analysis, 2009-10, Vol.50 (3), p.469-474

2009

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In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin

Journal of pharmaceutical sciences, 2012-08, Vol.101 (8), p.2854-2860

2012

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Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2- a]benzimidazoles

Bioorganic & medicinal chemistry, 2011-07, Vol.19 (13), p.4091-4100

2011

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L-Type amino acid transporter 1 as a target for drug delivery

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

The Role of Transporters in Future Chemotherapy

Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin

Incorporation of Sulfonamide Moiety into Biguanide Scaffold Results in Apoptosis Induction and Cell Cycle Arrest in MCF-7 Breast Cancer Cells

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Effective Cellular Transport of Ortho -Halogenated Sulfonamide Derivatives of Metformin Is Related to Improved Antiproliferative Activity and Apoptosis Induction in MCF-7 Cells

Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation

Metformin - a Future Therapy for Neurodegenerative Diseases

Sulfenamide derivatives can improve transporter-mediated cellular uptake of metformin and induce cytotoxicity in human breast adenocarcinoma cell lines

Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Sustained Release of Metformin via Red Blood Cell Accumulated Sulfenamide Prodrug

Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug

Novel halogenated sulfonamide biguanides with anti-coagulation properties

Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug

Benzenesulphonamide inhibitors of the cytolytic protein perforin

Diarylthiophenes as inhibitors of the pore-forming protein perforin

Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography

In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin

Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2- a]benzimidazoles

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